Studies of ionospheric absorption measurements

Ionospheric absorption measurements, and detection of anomalie

SOLID DISPERSION: A NOVEL APPROACH FOR POORLY WATER SOLUBLE DRUGS

Objective: Out of newly discovered drugs more than 40% pharmacologically active molecule having poor solubility. This is one of the serious challenge in the pharmaceutical industry and commercialization of the drug. Methods: With the introduction of new manufacturing technologies such as solid dispersion pH modification, SEED, salt formation, co crystallization. Results: it should be possible to overcome problems. Potential of solid dispersion technology has been well established for hydrophobic agents because of ease of optimization, simplicity and easy scale up. Conclusion: This article begins with an overview of the historical background and definition and importance of solubility and solid dispersion. The remainder of the article is devoted to the production, the different carriers and the methods used for the characterization of solid dispersions

A ternary PEDOT-TiO2-reduced graphene oxide nanocomposite for supercapacitor applications

A ternary composite of PEDOT was prepared with TiO2 via emulsion polymerization method adjusting various weight ratios of TiO2 to PEDOT and synthesized rGO was then blended with this composite. The FTIR, UV–Vis and XRD analysis displayed characteristic features of PEDOT and TiO2. The morphology of the nano-hybrid structure was additionally investigated by SEM analysis. Pore size and surface area analysis of particles were characterized by BET method. The electrochemical analysis showed that the specific capacitance (Csp) for PEDOT-TiO2-15-rGO was 18.9 F.cm-2 at 0.1 mA g-1 current density

Fructan and its relationship to abiotic stress tolerance in plants

Numerous studies have been published that attempted to correlate fructan concentrations with freezing and drought tolerance. Studies investigating the effect of fructan on liposomes indicated that a direct interaction between membranes and fructan was possible. This new area of research began to move fructan and its association with stress beyond mere correlation by confirming that fructan has the capacity to stabilize membranes during drying by inserting at least part of the polysaccharide into the lipid headgroup region of the membrane. This helps prevent leakage when water is removed from the system either during freezing or drought. When plants were transformed with the ability to synthesize fructan, a concomitant increase in drought and/or freezing tolerance was confirmed. These experiments indicate that besides an indirect effect of supplying tissues with hexose sugars, fructan has a direct protective effect that can be demonstrated by both model systems and genetic transformation

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer