The chemical characterization of Nigerian propolis samples and their activity against Trypanosoma brucei.

Profiling of extracts from twelve propolis samples collected from eight regions in Nigeria was carried out using high performance liquid chromatography (LC) coupled with evaporative light scattering (ELSD), ultraviolet detection (UV) and mass spectrometry (MS), gas chromatography mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). Principal component analysis (PCA) of the processed LC-MS data demonstrated the varying chemical composition of the samples. Most of the samples were active against Trypanosoma b.brucei with the highest activity being in the samples from Southern Nigeria. The more active samples were fractionated in order to isolate the component(s) responsible for their activity using medium pressure liquid chromatography (MPLC). Three xanthones, 1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone, 1,3,7-trihydroxy-4,8-di-(3-methylbut-2-enyl)xanthone a previously undescribed xanthone and three triterpenes: ambonic acid, mangiferonic acid and a mixture of α-amyrin with mangiferonic acid (1:3) were isolated and characterised by NMR and LC-MS. These compounds all displayed strong inhibitory activity against T.b.brucei but none of them had higher activity than the crude extracts. Partial least squares (PLS) modelling of the anti-trypanosomal activity of the sample extracts using the LC-MS data indicated that high activity in the extracts, as judged from LCMS 2data, could be correlated to denticulatain isomers in the extracts

Timing and interstellar scattering of 35 distant pulsars discovered in the palfa survey

We have made extensive observations of 35 distant slow (non-recycled) pulsars discovered in the ongoing Arecibo PALFA pulsar survey. Timing observations of these pulsars over several years at Arecibo Observatory and Jodrell Bank Observatory have yielded high-precision positions and measurements of rotation properties. Despite being a relatively distant population, these pulsars have properties that mirror those of the previously known pulsar population. Many of the sources exhibit timing noise, and one underwent a small glitch. We have used multifrequency data to measure the interstellar scattering properties of these pulsars. We find scattering to be higher than predicted along some lines of sight, particularly in the Cygnus region. Finally, we present XMM-Newton and Chandra observations of the youngest and most energetic of the pulsars, J1856+0245, which has previously been associated with the GeV-TeV pulsar wind nebula HESS J1857+026. © 2013. The American Astronomical Society. All rights reserved

Discovery of a gamma-ray black widow pulsar by GPU-accelerated Einstein@Home

We report the discovery of 1.97 ms period gamma-ray pulsations from the 75 minute orbital-period binary pulsar now named PSR J1653−0158. The associated Fermi Large Area Telescope gamma-ray source 4FGL J1653.6−0158 has long been expected to harbor a binary millisecond pulsar. Despite the pulsar-like gamma-ray spectrum and candidate optical/X-ray associations—whose periodic brightness modulations suggested an orbit—no radio pulsations had been found in many searches. The pulsar was discovered by directly searching the gamma-ray data using the GPU-accelerated Einstein@Home distributed volunteer computing system. The multidimensional parameter space was bounded by positional and orbital constraints obtained from the optical counterpart. More sensitive analyses of archival and new radio data using knowledge of the pulsar timing solution yield very stringent upper limits on radio emission. Any radio emission is thus either exceptionally weak, or eclipsed for a large fraction of the time. The pulsar has one of the three lowest inferred surface magnetic-field strengths of any known pulsar with B surf ≈ 4 × 107 G. The resulting mass function, combined with models of the companion star's optical light curve and spectra, suggests a pulsar mass gsim2 M ⊙. The companion is lightweight with mass ~0.01 M ⊙, and the orbital period is the shortest known for any rotation-powered binary pulsar. This discovery demonstrates the Fermi Large Area Telescope's potential to discover extreme pulsars that would otherwise remain undetected

A 350-MHz Green Bank Telescope Survey of Unassociated Fermi LAT Sources: Discovery and Timing of Ten Millisecond Pulsars

International audienceWe have searched for radio pulsations towards 49 Fermi Large Area Telescope (LAT) 1FGL Catalog $\gamma$-ray sources using the Green Bank Telescope at 350 MHz. We detected 18 millisecond pulsars (MSPs) in blind searches of the data; 10 of these were discoveries unique to our survey. Sixteen are binaries, with eight having short orbital periods $P_B < 1$ day. No radio pulsations from young pulsars were detected, although three targets are coincident with apparently radio-quiet $\gamma$-ray pulsars discovered in LAT data. Here, we give an overview of the survey and present radio and $\gamma$-ray timing results for the 10 MSPs discovered. These include the only isolated MSP discovered in our survey and six short-$P_B$ binary MSPs. Of these, three have very low-mass companions ($M_c$$\ll$ 0.1M$_{\odot}$) and hence belong to the class of black widow pulsars. Two have more massive, non-degenerate companions with extensive radio eclipses and orbitally modulated X-ray emission consistent with the redback class. Significant $\gamma$-ray pulsations have been detected from nine of the discoveries. This survey and similar efforts suggest that the majority of Galactic $\gamma$-ray sources at high Galactic latitudes are either MSPs or relatively nearby non-recycled pulsars, with the latter having on average a much smaller radio/$\gamma$-ray beaming ratio as compared to MSPs. It also confirms that past surveys suffered from an observational bias against finding short-$P_B$ MSP systems