Carrier relaxation dynamics in quantum dots: Scattering mechanisms and state-filling effects

Stressor-induced InxGa1−xAs quantum dot structures of high structural quality allow a detailed experimental investigation of carrier relaxation between distinct zero-dimensional quantized states. Time-resolved photoluminescence studies combined with appropriate model calculations show that state filling effects, Coulomb scattering, and acoustic phonon scattering determine the relaxation scenario in a way characteristic for a zero-dimensional electronic system. These investigations allow a quantitative estimation of the inter-dot-level relaxation rates mediated by (i) Coulomb scattering and (ii) acoustic phonon scattering.Peer reviewe

Should NICE reconsider the 2016 UK guidelines on TB contact tracing? A cost-effectiveness analysis of contact investigations in London.

BACKGROUND: In January 2016, clinical TB guidance in the UK changed to no longer recommend screening contacts of non-pulmonary, non-laryngeal (ETB) index cases. However, no new evidence was cited for this change, and there is evidence that screening these contacts may be worthwhile. The objective of this study was to estimate the cost-effectiveness of screening contacts of adult ETB cases and adult pulmonary or laryngeal TB (PTB) cases in London, UK. METHODS: We carried out a cross-sectional analysis of data collected on TB index cases and contacts in the London TB register and an economic evaluation using a static model describing contact tracing outcomes. Incremental cost-effectiveness ratios (ICERs) were calculated using no screening as the baseline comparator. All adult TB cases (≥15 years old) in London from 2012 to 2015, and their contacts, were eligible (2465/5084 PTB and 2559/6090 ETB index cases were included). RESULTS: Assuming each contact with PTB infects one person/month, the ICER of screening contacts of ETB cases was £78 000/quality-adjusted life-years (QALY) (95% CI 39 000 to 140 000), and screening contacts of PTB cases was £30 000/QALY (95% CI 18 000 to 50 000). The ICER of screening contacts of ETB cases was £30 000/QALY if each contact with PTB infects 3.4 people/month. Limitations of this study include the use of self-reported symptomatic periods and lack of knowledge about onward transmission from PTB contacts. CONCLUSIONS: Screening contacts of ETB cases in London was almost certainly not cost-effective at any conventional willingness-to-pay threshold in England, supporting recent changes to National Institute for Health and Care Excellence national guidelines

Empirische Shortcuts:Studentische Forschungsprojekte in der Methodenlehre

Die empirische Bildungsforschung hat in den letzten Jahren einen nachhaltigen quantitativen und qualitativen Aufschwung genommen. Erziehungswissenschaftliche Forschung erschöpft sich jedoch nicht im M&E des schulischen Lernstands im nationalen und internationalen Vergleich und seiner Ursachen sondern umfasst ein weites Feld an Fragestellungen aus unterschiedlichsten Bereichen. Dies muss den Studierenden, neben den methodischen Modellen und Instrumentarien exemplarisch vermittelt werden. Das ideale didaktische Modell hierfür ist zweifellos ein von den Studierenden selbst konzipiertes und durchgeführtes Forschungsprojekt, wie es seit Jahren im Programmbereich „Empirische Pädagogik“ des Instituts für Erziehungswissenschaft der WWU Münster praktiziert. Dadurch werden den Studierenden Dimensionen eröffnet, die im Zeitalter von Modularisierung, OECD-Statistiken und Ressourcenverknappung sich zunehmend verengen. Die damit verbundenen Impulse und Erfahrungsgewinne sind in eine Belebung und Bereicherung des Studiums

Metabolic engineering of astaxanthin biosynthesis in maize endosperm and characterization of a prototype high oil hybrid

Maize was genetically engineered for the biosynthesis of the high value carotenoid astaxanthin in the kernel endosperm. Introduction of a β-carotene hydroxylase and a β-carotene ketolase into a white maize genetic background extended the carotenoid pathway to astaxanthin. Simultaneously, phytoene synthase, the controlling enzyme of carotenogenesis, was over-expressed for enhanced carotenoid production and lycopene ε-cyclase was knocked-down to direct more precursors into the β-branch of the extended ketocarotenoid pathway which ends with astaxanthin. This astaxanthin-accumulating transgenic line was crossed into a high oil- maize genotype in order to increase the storage capacity for lipophilic astaxanthin. The high oil astaxanthin hybrid was compared to its astaxanthin producing parent. We report an in depth metabolomic and proteomic analysis which revealed major up- or down- regulation of genes involved in primary metabolism. Specifically, amino acid biosynthesis and the citric acid cycle which compete with the synthesis or utilization of pyruvate and glyceraldehyde 3-phosphate, the precursors for carotenogenesis, were down-regulated. Nevertheless, principal component analysis demonstrated that this compositional change is within the range of the two wild type parents used to generate the high oil producing astaxanthin hybrid

Predictors and Program Outcomes of Empowering Practices of FFA Chapter Advisors

Adults managing youth organizations strive to build partnerships with students in which the shared leadership process results in a sense of empowerment. This research investigates the predictors and programs outcomes of empowering practices used by FFA chapter advisors. Findings provide implications for preservice and continuing education

Program Planning Theory in Service-Learning: A Relational Model

This paper introduces the relationship between program planning theory and service-learning in graduate education and the development of a relational program planning model for service-learning. A case will be made regarding the value of the relational program planning model for guiding and enabling more democratic forms of service-learning practice

Sigmatropic rearrangements in 5-allyloxytetrazoles

Mechanisms of thermal isomerization of allyl tetrazolyl ethers derived from the carbocyclic allylic alcohols cyclohex-2-enol and 3-methylcyclohex-2-enol and from the natural terpene alcohol nerol were investigated. In the process of the syntheses of the three 1-aryl-5-allyloxytetrazoles, their rapid isomerization to the corresponding 1-aryl-4-allyltetrazol-5-ones occurred. The experiments showed that the imidates rearrange exclusively through a [3,3¢]-sigmatropic migration of the allylic system from O to N, with inversion. Mechanistic proposals are based on product analysis and extensive quantum chemical calculations at the DFT(B3LYP) and MP2 levels, on O-allyl and N-allyl isomers and on putative transition state structures for [1,3¢]- and [3,3¢]-sigmatropic migrations. The experimental observations could be only explained on the basis of the MP2/6-31G(d,p) calculations that favoured the [3,3¢]-sigmatropic migrations, yielding lower energies both for the transition states and for the final isomerization products

Diagnostische Möglichkeiten bei Kniegelenkverletzungen unter besonderer Berücksichtigung klinischer Meniskustests

Die Meniskusläsion stellt ein typisches Beispiel für ein Krankheitsbild dar, bei dem selten eine eindeutige Symptomatik vorliegt. In der klinischen Studie wurden die allgemeinen pathologischen Befunde und insbesondere zwölf spezielle klinische Tests detailliert in Bezug auf ihre Wertigkeit und Treffsicherheit bei Meniskusverletzungen anhand der Referenzmethode "Arthroskopie" analysiert. In der Studie zeichneten sich insbesondere der McMurray, Apley, Böhler und Steinmann I Test durch eine hohe Sensitivität aus, bei jedoch nur geringer Spezifität. Eine hohe Spezifität konnte für den Finochietto, Fouché und Bragard Test ermittelt werden. Die Resultate zeigen, dass die speziellen Meniskustests einzeln bei der Frage nach einer Meniskusläsion ungenau sind. Erst die gezielte Kombination ausgesuchter Tests führt schließlich zu einer besseren Diagnosesicherheit. Dadurch kann die Zahl der zusätzlichen apparativen diagnostischen Untersuchungsmethoden reduziert werden