Efficacy of the FlossPro Flosser versus Finger Flossing in Orthodontic Patients

Introduction: The maintenance of good oral hygiene among orthodontic patients is a challenge. The purpose of this study was to compare the oral hygiene habits, gingival health, and preference of orthodontic patients when using a floss aid compared to conventional finger flossing with a floss threader. Methods: Thirty-four adolescent and young adult patients with fixed orthodontic appliances and poor oral hygiene were enrolled from the Loma Linda University Graduate Orthodontic Clinic. This was a single blind crossover study. The patients were randomly assigned to one of two treatment groups (floss aid or finger floss) in phase I. After prophylaxis, subjects were instructed to use the floss aid or finger floss once a day and continue brushing for 4-5 weeks. Patients then had a washout period of 4-5 weeks. In phase II, patients were assigned to the alternate treatment group for another 4-5 weeks. Clinical measurements of gingival index (mGI), plaque index (mQPI) and full mouth bleeding score (FMBS) were recorded at baseline prior to prophylaxis and after 4-5 weeks of each treatment. A survey to assess oral hygiene habits and product preference was given at the end of each treatment and results were analyzed using the McNemar and McNemar-Bowker test. Statistical analysis for mGI, mQPI and FMBS was performed using Paired Sample t-test and a mixed model procedure. Results: The Paired Sample t-test indicated no significant difference between baseline scores for mGI, mQPI and FMBS at phase I and phase II. The mixed model procedure analyzed data for the effects of time, treatment and treatment sequence on mGI, mQPI and FMBS. Results revealed statistically significant improvements in mGI, mQPI and FMBS for both treatment groups over time, with the floss aid showing more improvement (P \u3c0.05). Percent frequency of mGI and mQPI scores after treatment for test (floss aid) and control (finger floss) groups showed improvements in both interproximal and middle regions of the teeth. Treatment sequence was not statistically significant for any of the indices. The McNemar test indicated a statistically significant difference in the time to complete flossing between the two treatment groups (P =0.002). After using both the test and control products, 85.3% of subjects preferred the test product. Conclusions: Both the floss aid and conventional finger flossing were effective at reducing plaque, gingival inflammation and bleeding over time. Although the statistical analysis model showed more improvement in all indices with the floss aid, the improvements were small and not clinically significant

Supply chain integration strategies in fast evolving industries

Purpose - The purpose of this paper is to define the "fast evolving industry" (FEI) and its supply chain management (SCM) challenges. The authors review and structure the literature regarding integration strategies and implementation methods to develop a strategic decision-making framework for SCM in the FEI. Design/methodology/approach - The authors conduct a review of SCM literature, including supply chain strategy, supply chain integration (SCI), agile and responsive supply chain and SCM for innovative and fast-changing industries. The authors develop a conceptual model and a decision-making framework and use four mini cases to provide support for the model and framework. Findings - The FEI, characterised by a high level of innovation and differentiation, short products/services lifecycle and high variety, is yet to be fully defined. Inherent uncertainty in FEI supply systems makes SCM in these industries a complex but strategic task for their managers. The framework and the model offered in this study, which employ a core competency concept and provide risk management strategies, offer a strategic tool for managers and scholars in the field to optimise their integration strategies and to operationalise integration decisions. Originality/value - Little research has been published on transferable and cross-industrial SCM in FEIs. This paper defines the FEI and its resource-related concerns and then offers a conceptual model and a strategic decision-making framework for SCI in FEIs

A comparative study on body shape of the genus Alburnus (Rafinesque, 1820) in Iran, using geometric morphometric analysis

Geometric morphometric method was used to examine body shape variations among all the seven valid species of the genus Alburnus in Iran. In total 409 specimens of A. chalcoides, A. filippii, A. atropatenae, A. caeruleus, A. mossulensis, A. hohenackeri and A. zagrosensis were collected from Babolrud, Baleqlu-Chai, Miriseh, Sarabeleh, Gamasiyab, Mahabad-Chai Rivers and the Gandoman lagoon, respectively. Shape data was extracted by recording 15 landmark points on 2-D pictures of specimens. The PCA, DFA and CVA/MANOVA analysis were used to examine shape differences among the seven species. Significant differences were found among the species in term of body shape. The PCA and CVA/MANOVA showed separation of A. hohenackeri and A. caeruleus from the others. Results revealed that the studied species are divided into two categories; a group with great body depth and short caudal peduncle and the other one with shallow body depth and longer caudal peduncle. The obtained body shape properties can provide a shape-based identification key for the genus Alburnus in Iran, useful for fisheries and stock management or conservation programs

Fibulin-2 is required for basement membrane integrity of mammary epithelium

Fibulin-2 (FBLN2) is a secreted extracellular matrix glycoprotein which has been associated with tissue development and remodelling. In the mouse mammary gland, FBLN2 can be detected during ductal morphogenesis in cap cells and myoepithelial cells at puberty and early pregnancy, respectively. In an attempt to assign its function, we knocked down Fbln2 in the mouse mammary epithelial cell line EpH4. FBLN2 reduction led to an increase in the size of spheroidal structures when compared to scrambled control shRNA-transduced cells plated on Matrigel matrix. This phenotype was associated with a disruption of the collagen IV sheath around the epithelial spheroids and downregulation of integrin β1, suggesting a role for FBLN2 in stabilizing the basement membrane (BM). In contrast to mice, in normal adult human breast tissue, FBLN2 was detected in ductal stroma, and in the interlobular stroma, but was not detectable within the lobular regions. In tissue sections of 65 breast cancers FBLN2 staining was lost around malignant cells with retained staining in the neighbouring histologically normal tissue margins. These results are consistent with a role of FBLN2 in mammary epithelial BM stability, and that its down-regulation in breast cancer is associated with loss of the BM and early invasion

Cash-based interventions to enhance dignity in persistent humanitarian refugee crises: a system dynamics approach

Cash-based interventions (CBIs) as one form of aid have recently received substantial interest from humanitarian organizations in persistent humanitarian crises. This article proposes a system dynamics (SD) approach to study the CBIs' impact factors on all aspects of the beneficiaries' dignity in longstanding refugee crises, such as the case of Syrian refugees in Turkey. Reviewing the humanitarian management literature,we first develop a set of holistic causal loops to better understand the building boxes of refugees’ dignity and their interactions. Then, an SD model is proposed and calibrated by field data from humanitarian organizations. The result of CBI amount sensitivity and payment time periods shows that CBIs are significantly more effective in diminishing child labor rates and to improve in health and accommodation service reception by the refugees in short terms, but to be as much effective in longer terms, humanitarian organizations must be more directly contribute to service capacity-building activities that are strategies by the hosting governments and supported by the international bodies, such as EU and UN.Otherwise, long-term or enhanced CBI supports can only lead to accelerated service capacity saturation and thus put extra pressure on already strained services and cause tensions between hosting and refugee communities

Fibulin-2 is required for basement membrane integrity of mammary epithelium

Fibulin-2 (FBLN2) is a secreted extracellular matrix glycoprotein which has been associated with tissue development and remodelling. In the mouse mammary gland, FBLN2 can be detected during ductal morphogenesis in cap cells and myoepithelial cells at puberty and early pregnancy, respectively. In an attempt to assign its function, we knocked down Fbln2 in the mouse mammary epithelial cell line EpH4. FBLN2 reduction led to an increase in the size of spheroidal structures when compared to scrambled control shRNA-transduced cells plated on Matrigel matrix. This phenotype was associated with a disruption of the collagen IV sheath around the epithelial spheroids and downregulation of integrin β1, suggesting a role for FBLN2 in stabilizing the basement membrane (BM). In contrast to mice, in normal adult human breast tissue, FBLN2 was detected in ductal stroma, and in the interlobular stroma, but was not detectable within the lobular regions. In tissue sections of 65 breast cancers FBLN2 staining was lost around malignant cells with retained staining in the neighbouring histologically normal tissue margins. These results are consistent with a role of FBLN2 in mammary epithelial BM stability, and that its down-regulation in breast cancer is associated with loss of the BM and early invasion

Screening and diagnostic assessment of neurodevelopmental disorders in a male prison

Purpose The purpose of this paper is to identify neurodevelopmental disorders and difficulties (NDD) in a male prison. The study used standardised tools to carry out screening and diagnostic assessment of the attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and intellectual disability (ID). Design/methodology/approach The ADHD self-report scale, 20-item autism quotient and the Learning Disability Screening Questionnaire were used to screen 240 male prisoners. Prisoners who screened positive on one or more of these scales or self-reported a diagnosis of ADHD, ASD or ID were further assessed using the diagnostic interview for ADHD in adults, adapted Autism Diagnostic Observation Schedule and the Quick Test. Findings Of the 87 prisoners who screened positive for NDD and were further assessed, 70 met the study’s diagnostic criteria for ADHD, ASD or ID. Most of those with NDD (51 per cent) had previously gone unrecognised and a high proportion (51 per cent) were identified through staff- or self-referral to the study. Originality/value The study demonstrated that improving awareness and providing access to skilled, standardised assessment within a male prison can result in increased recognition and identification of NDD

Migration of Epithelium During Phenytoin-Dependent Gingival Overgrowth in Mice

A small cavity was made in the mesiopalatal area of the maxillary first molar adjacent to the gingiva. Mice were maintained on 40 mg/kg phenytoin (or on diluent for control) by daily intraperitoneal injections. After 9 weeks, light microscopic observations revealed that in experimental mice, epithelial cells migrated towards the cavity and covered it. In controls, epithelial cell migration towards the cavity did not occur. For scanning electron microscopic (SEM) studies, specimens were fixed in 4% glutaraldehyde in 0.1 M phosphate buffer, pH 7.2, for 2 hours, dehydrated, critical point dried and coated with gold. The surface of the outer gingival epithelium of experimental and of control mice showed a honeycomb arrangement of the microridges suggesting their keratinized nature. Epithelial cells lining the cavity showed well marked macroridges along their borders. Parallel microridges were observed on the upper surface of these cells suggesting that they were non-keratinized. It was concluded that the migrating epithelial cells, that covered the cavity during phenytoin-dependent gingival overgrowth, were of the non-keratinized type