Hybrid biomedical intelligent systems

"Copyright © 2012 Maysam Abbod et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."The purpose of this special issue is to promote research and developments of the best work in the field of hybrid intelligent systems for biomedical applications

Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila.

Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping, and is regulated by transcription factor binding, RNA polymerase II (RNAPII) recruitment and elongation, and post-transcriptional mechanisms. Recently, it has become clear that dynamic alterations in chromatin landscape at the level of histone posttranslational modification and nucleosome density facilitate rhythms in transcription factor recruitment and RNAPII activity, and are essential for progression through activating and repressive phases of circadian transcription. Here, we discuss the characterization of the BRAHMA (BRM) chromatin-remodeling protein in Drosophila in the context of circadian clock regulation. By dissecting its catalytic vs. non-catalytic activities, we propose a model in which the non-catalytic activity of BRM functions to recruit repressive factors to limit the transcriptional output of CLOCK (CLK) during the active phase of circadian transcription, while the primary function of the ATP-dependent catalytic activity is to tune and prevent over-recruitment of negative regulators by increasing nucleosome density. Finally, we divulge ongoing efforts and investigative directions toward a deeper mechanistic understanding of transcriptional regulation of circadian gene expression at the chromatin level

Computational reacting gas dynamics

In the study of high speed flows at high altitudes, such as that encountered by re-entry spacecrafts, the interaction of chemical reactions and other non-equilibrium processes in the flow field with the gas dynamics is crucial. Generally speaking, problems of this level of complexity must resort to numerical methods for solutions, using sophisticated computational fluid dynamics (CFD) codes. The difficulties introduced by reacting gas dynamics can be classified into three distinct headings: (1) the usually inadequate knowledge of the reaction rate coefficients in the non-equilibrium reaction system; (2) the vastly larger number of unknowns involved in the computation and the expected stiffness of the equations; and (3) the interpretation of the detailed reacting CFD numerical results. The research performed accepts the premise that reacting flows of practical interest in the future will in general be too complex or 'untractable' for traditional analytical developments. The power of modern computers must be exploited. However, instead of focusing solely on the construction of numerical solutions of full-model equations, attention is also directed to the 'derivation' of the simplified model from the given full-model. In other words, the present research aims to utilize computations to do tasks which have traditionally been done by skilled theoreticians: to reduce an originally complex full-model system into an approximate but otherwise equivalent simplified model system. The tacit assumption is that once the appropriate simplified model is derived, the interpretation of the detailed numerical reacting CFD numerical results will become much easier. The approach of the research is called computational singular perturbation (CSP)

Implementing Unitarity in Perturbation Theory

Unitarity cannot be perserved order by order in ordinary perturbation theory because the constraint UU^\dagger=\1 is nonlinear. However, the corresponding constraint for $K=\ln U$, being $K=-K^\dagger$, is linear so it can be maintained in every order in a perturbative expansion of $K$. The perturbative expansion of $K$ may be considered as a non-abelian generalization of the linked-cluster expansion in probability theory and in statistical mechanics, and possesses similar advantages resulting from separating the short-range correlations from long-range effects. This point is illustrated in two QCD examples, in which delicate cancellations encountered in summing Feynman diagrams of are avoided when they are calculated via the perturbative expansion of $K$. Applications to other problems are briefly discussed.Comment: to appear in Phys. Rev.

Optimization on the financial management of the bank with goal programming model

Financial management is crucial for planning bank’s asset and liabilities while takingconsideration for multiple objectives. The objective of this study is to develop a GoalProgramming (GP) model to optimize the financial management of Public Bank Berhad inMalaysia. Six goals from the financial statements namely total asset, total liability, total equity, profit, earning and optimum management items are investigated for the period from 2011 to 2015. The results of this study indicate that all six goals are fully achieved by using the GP model. This study is significant because it helps to develop a mathematical model to examine the financial strengths of Public Bank Berhad in Malaysia. Besides that, the potential improvement on liability, equity, profit, earning and optimum management item of Public Bank Berhadcan be identified in this study based on the deviation from the target value.Keywords: Asset; Liability; Equity; Profit; Earning; Optimum Management Item

Ion collection by oblique surfaces of an object in a transversely-flowing strongly-magnetized plasma

The equations governing a collisionless obliquely-flowing plasma around an ion-absorbing object in a strong magnetic field are shown to have an exact analytic solution even for arbitrary (two-dimensional) object-shape, when temperature is uniform, and diffusive transport can be ignored. The solution has an extremely simple geometric embodiment. It shows that the ion collection flux density to a convex body's surface depends only upon the orientation of the surface, and provides the theoretical justification and calibration of oblique `Mach-probes'. The exponential form of this exact solution helps explain the approximate fit of this function to previous numerical solutions.Comment: Four pages, 2 figures. Submitted to Phys. Rev. Letter

Phase II of the ASCE Benchmark Study on SHM

The task group on structural health monitoring of the Dynamic Committee of ASCE was formed in 1999 at the 12 th Engineering Mechanics Conference. The task group has designed a number of analytical studies on a benchmark structure and there are plans to follow these with an experimental program. The first phase of the analytical studies was completed in 2001. The second phase, initiated in the summer of 2001, was formulated in the light of the experience gained on phase I and focuses on increasing realism in the simulation of the discrepancies between the actual structure and the mathematical model used in the analysis. This paper describes the rational that lead the SHM task group to the definition of phase II and presents the details of the cases that are being considered

Finite Symmetry of Leptonic Mass Matrices

We search for possible symmetries present in the leptonic mixing data from SU(3) subgroups of order up to 511. Theoretical results based on symmetry are compared with global fits of experimental data in a chi-squared analysis, yielding the following results. There is no longer a group that can produce all the mixing data without a free parameter, but a number of them can accommodate the first or the second column of the mixing matrix. The only group that fits the third column is $\Delta(150)$. It predicts $\sin^22\theta_{13}=0.11$ and $\sin^22\theta_{23}=0.94$, in good agreement with experimental results.Comment: Version to appear in Physical Review