1,184 research outputs found
Speeding Strings
There is a class of single trace operators in Yang-Mills theory
which are related by the AdS/CFT correspondence to classical string solutions.
Interesting examples of such solutions corresponding to periodic trajectories
of the Neumann system were studied recently. In our paper we study a
generalization of these solutions. We consider strings moving with large
velocities. We show that the worldsheet of the fast moving string can be
considered as a perturbation of the degenerate worldsheet, with the small
parameter being the relativistic factor . The series expansion in
this relativistic factor should correspond to the perturbative expansion in the
dual Yang-Mills theory. The operators minimizing the anomalous dimension in the
sector with given charges correspond to periodic trajectories in the mechanical
system which is closely related to the product of two Neumann systems.Comment: v3: added a reference to the earlier wor
Entrepreneurship in national economics: significance and potential of development
The purpose of the study was to develop proposals for the use of two comprehensive indexes to assess the social significance and the existing potential for entrepreneurship development in different countries. The study used information provided in the report on the Global entrepreneurship monitoring project. At the same time, the opinions of residents of 48 countries for 2018 were considered. The first index included four indicators, and the second index included five indicators. Mathematical models were developed and the values of these two complex indexes were calculated. The average values of the indexes and their ranges of change for most countries are determined. Lists of countries with high and low index values are given. A comparative analysis of the values of complex indexes typical for Russia and other countries is presented. The results of research are new and original, have scientific and practical significance
Phase transitions and phase diagram of the ferroelectric perovskite NBT-BT by anelastic and dielectric measurements
The complex elastic compliance and dielectric susceptibility of
(Na_{0.5}Bi_{0.5})_{1-x}Ba_{x}TiO_{3} (NBT-BT) have been measured in the
composition range between pure NBT and the morphotropic phase boundary
included, 0 <= x <= 0.08. The compliance of NBT presents sharp peaks at the
rhombohedral/tetragonal and tetragonal/cubic transitions, allowing the
determination of the tetragonal region of the phase diagram, up to now
impossible due to the strong lattice disorder and small distortions and
polarizations involved. In spite of ample evidence of disorder and structural
heterogeneity, the R-T transition remains sharp up to x = 0.06, whereas the T-C
transition merges into the diffuse and relaxor-like transition associated with
broad maxima of the dielectric and elastic susceptibilities. An attempt is made
at relating the different features in the anelastic and dielectric curves to
different modes of octahedral rotations and polar cation shifts. The
possibility is also considered that the cation displacements locally have
monoclinic symmetry, as for PZT near the morphotropic phase boundary.Comment: 11 pages, 9 figures, submitted to Phys. Rev.
Technological Developments and the Role of L2 Motivation in University English Language Teaching Education
The 21st century is the era of technology and digitalization in teaching and learning dynamics., The present study explores the function of L2 motivation in university-based English language teaching (ELT) education. It also seeks to comprehend how technological developments are changing L2 motivation and examines teachers coping mechanisms in this changing educational environment. This study employs a qualitative research approach to explore the university teachers choices of technology instruments and pedagogical choices for enhancing studentsβ L2 motivation. Thus, the study uses semi-structured interviews to collect data from the 15 university teachers, (8 from Pakistan and 7 from Russia). Moreover, the secondary aim of the study is to comprehend the variables influencing L2 teacher motivation, and pedagogical approaches. This study adds to the body of information on language teaching by emphasizing the necessity for university teachers to adapt to changes in L2 motivation by utilizing technology, developing cutting-edge resources, and creating motivating learning settings
Understanding the Complexity of Motivational Orientations towards Learning English among Pakistani Female University Students
The present study goal is to investigate female university studentsβ motivation toward learning English as Second Language (ESL) studying at the University of Sindh, Pakistan. Two main objectives of the study were to evaluate the motivational orientation of the female learners in terms of integrativeness or instrumentality. Second, to study the factors that affect the learners motivation towards learning English. A mixed-method approach was employed with descriptive and inferential statistics were performed on the data to evaluate the data. A number of 158 female students from both the Science and Arts faculties at the English and Chemistry departments filled the structured questionnaire. Additionally, to gain a deeper understanding of the researched phenomenon, the semi-structured interviews were conducted with 20 students. The findings revealed a complex portrait of the target population, with the most prominent motivational factors being integrative motive, classroom environment, and instrumental motive. Besides, the influence of teachers was found to induce behavioral changes, while gender did not appear to significantly impact the learning process
On stress/strain state in a rotating disk
In the framework of mechanics of continuum bodies, the problem of stress/strain state in a high-speed rotating disk of constant thickness has been considered. The material of the disk is assumed to be homogeneous, elastic/perfectly-plastic. In the plastic zone, the stresses and plastic strains are related by some associated law similar to the one employed in deformation theory of plasticity. The general algorithm of the solution covers any smooth plasticity function. At some steps of the algorithm, it is possible to get analytical expressions, particularly, for the quadratic Mises yield criterion. For the given model, the notion of control parameters (external and internal) has been introduced. The allowable boundaries of external parameters have been deο¬ned as well. For some states of the disk, the coherent values of external parameters have been obtained. The results are represented graphically to show various states of the disk. The usage of piecewise plasticity functions has been brieο¬y discussed. The results obtained can be used in preliminary engineering design and related numerical codes.info:eu-repo/semantics/publishedVersio
Π Π°Π±ΠΎΡΠ°Ρ ΡΠΌΠ΅Π½Π°: Π²ΠΎΡΠΏΠΎΠ»Π½ΠΈΡ Π»ΠΈ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΡ ΠΊΠ°Π΄ΡΠΎΠ²ΡΠΉ Π΄Π΅ΡΠΈΡΠΈΡ Π² ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΡΡΠΈ ΠΈ Π°Π³ΡΠ°ΡΠ½ΠΎ-ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ΅?
ΠΠ΅ΡΠΈΡΠΈΡ ΠΊΠ²Π°Π»ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ°Π±ΠΎΡΠΈΡ
ΠΊΠ°Π΄ΡΠΎΠ² ΠΎΡΡΠ°Π΅ΡΡΡ ΠΎΡΡΡΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ ΡΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ ΠΊΡΠΈΠ·ΠΈΡΠ° 2008β2009 Π³Π³. Π ΡΡΠ°ΡΡΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π΄Π²ΡΡ
ΡΠΎΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
Π² ΡΠ΅Π³ΠΈΠΎΠ½Π°Ρ
Π ΠΎΡΡΠΈΠΈ Ρ ΠΎΡΡΠ΅ΡΠ»ΠΈΠ²ΠΎΠΉ ΠΎΡΡΠ°ΡΠ»Π΅Π²ΠΎΠΉ ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΠ·Π°ΡΠΈΠ΅ΠΉ ΠΈ ΠΏΡΠ΅Π΄ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π²ΡΠΈΡ
Π°Π½ΠΊΠ΅ΡΠ½ΡΠΉ ΠΎΠΏΡΠΎΡ ΡΡΠ°ΡΠΈΡ
ΡΡ ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΏΡΠΎΡΡΠ΅Ρ
ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΊΡΠΏΠ΅ΡΡΠ½ΡΠ΅ ΠΈΠ½ΡΠ΅ΡΠ²ΡΡ Ρ ΡΡΠΊΠΎΠ²ΠΎΠ΄ΡΡΠ²ΠΎΠΌ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΠΉ, ΠΎΡΡΠ°ΡΠ»Π΅Π²ΡΡ
Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΉ, ΡΠΎΡΠ³ΠΎΠ²ΠΎ-ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΡΡ
ΠΏΠ°Π»Π°Ρ ΠΈ ΡΡΠΊΠΎ-Π²ΠΎΠ΄ΠΈΡΠ΅Π»ΡΠΌΠΈ ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΏΡΠΎΡΡΠ΅Ρ
ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ. Π‘ΠΎΠ±ΡΠ°Π½Π½ΡΠΉ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π» Π΄Π°Π΅Ρ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ ΡΠΎΠΌ, ΠΊΠ°ΠΊΠΎΠΉ ΠΊΠΎΠ½ΡΠΈΠ½Π³Π΅Π½Ρ ΠΈ ΠΏΠΎΡΠ΅ΠΌΡ ΠΏΡΠΈΡ
ΠΎΠ΄ΠΈΡ ΡΡΠΈΡΡΡΡ ΡΠ°Π±ΠΎΡΠΈΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠΈΡΠΌ; ΠΊΠ°ΠΊΠΈΠΌ Π²ΠΈΠ΄ΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΡ ΡΠ²ΠΎΠ΅ ΡΡΡΠ΄ΠΎΡΡΡΡΠΎΠΉΡΡΠ²ΠΎ ΠΏΠΎ ΠΎΠΊΠΎΠ½ΡΠ°Π½ΠΈΠΈ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ; ΠΏΠΎΡΠ΅ΠΌΡ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΡΠΌ ΠΏΠΎ-ΠΏΡΠ΅ΠΆΠ½Π΅ΠΌΡ ΡΠ»ΠΎΠΆΠ½ΠΎ Π²ΠΎΡΠΏΠΎΠ»Π½ΡΡΡ ΠΊΠ°Π΄ΡΠΎΠ²ΡΠΉ Π΄Π΅ΡΠΈΡΠΈΡ; ΠΏΠΎΡΠ²ΠΈΠ»Π°ΡΡ Π»ΠΈ Ρ Π±ΠΈΠ·Π½Π΅ΡΠ° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π΄ΠΎΠ»Π³ΠΎΡΡΠΎΡΠ½ΠΎ ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²Π°ΡΡ ΡΠ²ΠΎΠΈ ΠΊΠ°Π΄ΡΠΎΠ²ΡΠ΅ ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΠΈ, Π° Ρ ΡΠΈΡΡΠ΅ΠΌΡ ΠΏΡΠΎΡΡΠ΅Ρ
ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ β ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ Π½Π° Π½ΠΈΡ
ΠΎΡΠ²Π΅ΡΠ°ΡΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π²ΡΠ±ΠΎΡ ΡΠ°Π±ΠΎΡΠ΅ΠΉ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ Π½Π°Π΄Π΅ΠΆΠ΄ΠΎΠΉ Π½Π° Π΄ΠΎΡΡΠΎΠΉΠ½ΠΎ ΠΎΠΏΠ»Π°ΡΠΈΠ²Π°Π΅ΠΌΡΡ ΡΠ°Π±ΠΎΡΡ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΡ Π² ΠΊΠΎΡΠΎΡΠΊΠΈΠΉ ΡΡΠΎΠΊ ΠΏΠΎΠ»ΡΡΠΈΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΈΡ ΠΈ Π»Π΅Π³ΠΊΠΎΡΡΡΡ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΡ Π² ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΠΎΠ»ΡΡΠ΅ ΠΏΠΎΠ»ΠΎΠ²ΠΈΠ½Ρ ΡΡΠ°ΡΠΈΡ
ΡΡ ΡΠΎΠ³Π»Π°ΡΠ½Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ ΡΠΎ Π²ΡΠ΅ΠΌΠΈ ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΠΌΠΈ ΡΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΈΡΠΌΠΈ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ°Π±ΠΎΡΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΉ, Π½ΠΎ Π² ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ Π΄Π²Π΅ ΡΡΠ΅ΡΠΈ ΠΏΠΎΠ½ΠΈΠΌΠ°ΡΡ, ΡΡΠΎ ΠΎΠ½ΠΈ ΡΠ²ΡΠ·Π°Π½Ρ Ρ ΡΡΠΆΠ΅Π»ΡΠΌΠΈ Π»ΠΈΠ±ΠΎ ΠΎΠΏΠ°ΡΠ½ΡΠΌΠΈ ΡΡΠ»ΠΎΠ²ΠΈΡΠΌΠΈ ΡΡΡΠ΄Π°. Π₯ΠΎΡΡ ΠΏΠΎ ΠΎΠΊΠΎΠ½ΡΠ°Π½ΠΈΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠΈ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ ΡΠ΅ΡΠΏΠΎΠ½Π΄Π΅Π½ΡΠΎΠ² ΡΠ±Π΅Π΄ΠΈΠ»ΠΈΡΡ Π² Π²Π΅ΡΠ½ΠΎΡΡΠΈ Π²ΡΠ±ΠΎΡΠ° ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΈ, Π² ΡΠ΅Ρ
Π° ΠΈ Π½Π° ΠΏΠΎΠ»Ρ ΠΈΠ΄ΡΡ Π΄Π°Π»Π΅ΠΊΠΎ Π½Π΅ Π²ΡΠ΅, ΡΡΠΎ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ Π½Π΅Π²ΡΡΠΎΠΊΠΎΠΉ Π·Π°ΡΠΏΠ»Π°ΡΠΎΠΉ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
ΠΊΠ°Π΄ΡΠΎΠ² ΠΈ/ ΠΈΠ»ΠΈ ΠΌΠ΅ΡΡΠΎΠΌ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΡ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²Ρ Π² Π²ΠΈΠ΄Π΅ ΡΠ°Π±ΠΎΡΡ Π² ΡΠΎΡΠ³ΠΎΠ²Π»Π΅ ΠΈΠ»ΠΈ ΡΠ΅ΡΠ²ΠΈΡΠ΅. ΠΠΎΡΠΎΡΠΊΠΈΠΉ Π³ΠΎΡΠΈΠ·ΠΎΠ½Ρ ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ Π½ΠΈΠ·ΠΊΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ΅Π½ΡΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΠΈ Π½Π΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΡΠΌ ΠΏΡΠΎΡΡΠΈΡΡΠ²Π°ΡΡ ΡΠ²ΠΎΠΈ ΠΊΠ°Π΄ΡΠΎΠ²ΡΠ΅ ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΠΈ ΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°ΡΡ ΠΊΠ°Π΄ΡΠΎΠ²ΡΠΉ ΡΠ΅Π·Π΅ΡΠ², ΡΡΠΎ Π΄Π΅Π·ΠΎΡΠΈΠ΅Π½ΡΠΈΡΡΠ΅Ρ ΡΠΈΡΡΠ΅ΠΌΡ ΠΏΡΠΎΡΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΊΠΎΠ½ΡΠ΅ΡΠ²ΠΈΡΡΠ΅Ρ Π΄ΠΈΡΠ±Π°Π»Π°Π½ΡΡ Π½Π° ΡΡΠ½ΠΊΠ΅ ΡΡΡΠ΄Π°. Π£Π»ΡΡΡΠ΅Π½ΠΈΡ ΡΠΈΡΡΠ°ΡΠΈΠΈ, ΠΏΠΎ ΠΌΠ½Π΅Π½ΠΈΡ ΠΊΠ°ΠΊ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ, ΡΠ°ΠΊ ΠΈ ΡΠΊΡΠΏΠ΅ΡΡΠΎΠ², ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°Π»ΠΎ Π±Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²ΠΎΠΌ Π±ΠΎΠ»Π΅Π΅ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΏΠΎΠ»ΠΈΡΠΈΠΊΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠΈ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΡΡΠΈ ΠΈ Π°Π³ΡΠ°ΡΠ½ΠΎ-ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΠΌ ΠΊΠΎΠΌ-ΠΏΠ»Π΅ΠΊΡΠ΅ (ΠΠΠ)
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance
Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics. The main clinically relevant mechanism of resistance to macrolides is dimethylation of the 23S rRNA nucleotide A2058, located in the drug-binding site, a reaction catalyzed by Erm-type rRNA methyltransferases. Here, we present the crystal structure of the Erm-dimethylated 70S ribosome at 2.4βΓ
resolution, together with the structures of unmethylated 70S ribosome functional complexes alone or in combination with macrolides. Altogether, our structural data do not support previous models and, instead, suggest a principally new explanation of how A2058 dimethylation confers resistance to macrolides. Moreover, high-resolution structures of two macrolide antibiotics bound to the unmodified ribosome reveal a previously unknown role of the desosamine moiety in drug binding, laying a foundation for the rational knowledge-based design of macrolides that can overcome Erm-mediated resistance
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