Beam loading assisted matching scheme for high quality plasma acceleration in linear regime

We propose and we numerically design a working point for beam driven plasma wakefield acceleration that allows us to preserve the witness quality. This working point is a new scheme where a low density driver generates a wakefield in linear regime and the witness transverse evolution is dominated by the beam loading effect. We derived optimal matching conditions to prevent the phase space degradation by means of a transverse envelope equation

EuPRAXIA@SPARC_LAB: the high-brightness RF photo-injector layout proposal

At EuPRAXIA@SPARC_LAB, the unique combination of an advanced high-brightness RF injector and a plasma-based accelerator will drive a new multi-disciplinary user-facility. The facility, that is currently under study at INFN-LNF Laboratories (Frascati, Italy) in synergy with the EuPRAXIA collaboration, will operate the plasma-based accelerator in the external injection configuration. Since in this configuration the stability and reproducibility of the acceleration process in the plasma stage is strongly influenced by the RF-generated electron beam, the main challenge for the RF injector design is related to generating and handling high quality electron beams. In the last decades of R&D activity, the crucial role of high-brightness RF photo-injectors in the fields of radiation generation and advanced acceleration schemes has been largely established, making them effective candidates to drive plasma-based accelerators as pilots for user facilities. An RF injector consisting in a high-brightness S-band photo-injector followed by an advanced X-band linac has been proposed for the EuPRAXIA@SPARC_LAB project. The electron beam dynamics in the photo-injector has been explored by means of simulations, resulting in high-brightness, ultra-short bunches with up to 3 kA peak current at the entrance of the advanced X-band linac booster. The EuPRAXIA@SPARC_LAB high-brightness photo-injector is described here together with performance optimisation and sensitivity studies aiming to actual check the robustness and reliability of the desired working point.Comment: 5 pages,5 figures, EAAC201

A multicenter retrospective clinical study of CD5/CD10-negative chronic B cell leukemias.

CD5-negative chronic B cell lymphoproliferative disorders in leukemic phase (B-CLPD) are heterogeneous and relatively uncommon pathologies that often lack a histopathological definition because of the absence of accessible pathological tissue. We describe the clinical features and evolution-related variables of 156 patients with CD5/CD10-negative B-CLPD (median age 66 years, range 25-86). The median follow-up was 51 months (range 6-216), and overall 3- and 5-year survival was respectively 87 and 76%; 50 patients needed therapy at diagnosis, 56 during follow-up, and 50 remained untreated until the last control. A combined clinical, histological, cytomorphological, immunophenotypical, and cytogenetic diagnostic approach allowed the complete classification of only a minority of patients as being affected by splenic marginal zone or lymphoplasmacytic lymphoma; the majority of cases remained unclassifiable. Multivariate analysis showed that the clinicohematological variables adversely related to overall survival were serum LDH levels and age, whereas high serum LDH levels, hemoglobin levels of <11 g/dl, and splenomegaly related to treatment-free time (in "wait and see" cases); only splenomegaly related to time to progression (in treated patients). In conclusion, our retrospective study describes the clinical features and variables related to evolution in a large group of patients with CD5/CD10-negative chronic B-cell lymphoid leukemias and underlines the fact that a probable lymphoplasmacytic or marginal zone normal cell origin can be supposed in such leukemic forms, but never surely demonstrated

EUPRAXIA@SPARC_LAB: Beam Dynamics studies for the X-band Linac

In the framework of the Eupraxia Design Study an advanced accelerator facility EUPRAXIA@SPARC_LAB has been proposed to be realized at Frascati (Italy) Laboratories of INFN. Two advanced acceleration schemes will be applied, namely an ultimate high gradient 1 GeV X-band linac together with a plasma acceleration stage to provide accelerating gradients of the GeV/m order. A FEL scheme is foreseen to produce X-ray beams within 3-10 nm range. A 500-TW Laser system is also foreseen for electron and ion production experiments and a Compton backscattering Interaction is planned together with extraction beamlines at intermediate electron beam energy for neutron beams and THz radiation production. The electron beam dynamics studies in the linac are here presented together with the preliminary machine layout.Comment: 5 pages, 3 figures, NIM-A proceedings of EAAC201

Multi-GeV Electron Spectrometer

The advance in laser plasma acceleration techniques pushes the regime of the resulting accelerated particles to higher energies and intensities. In particular the upcoming experiments with the FLAME laser at LNF will enter the GeV regime with almost 1pC of electrons. From the current status of understanding of the acceleration mechanism, relatively large angular and energy spreads are expected. There is therefore the need to develop a device capable to measure the energy of electrons over three orders of magnitude (few MeV to few GeV) under still unknown angular divergences. Within the PlasmonX experiment at LNF a spectrometer is being constructed to perform these measurements. It is made of an electro-magnet and a screen made of scintillating fibers for the measurement of the trajectories of the particles. The large range of operation, the huge number of particles and the need to focus the divergence present unprecedented challenges in the design and construction of such a device. We will present the design considerations for this spectrometer and the first results from a prototype.Comment: 7 pages, 6 figures, submitted to NIM

RF injector design studies for the trailing witness bunch for a plasma-based user facility

The interest in plasma-based accelerators as drivers of user facilities is growing worldwide thanks to its compactness and reduced costs. In this context the EuPRAXIA collaboration is preparing a conceptual design report for a multi-GeV plasma-based accelerator with outstanding electron beam quality to pilot, among several applications, the operation of an X-ray FEL, the most demanding in terms of beam brightness. Intense beam dynamics studies have been performed to provide a reliable working point for the RF injector to generate a high-brightness trailing witness bunch suitable in external injection schemes, both in particle beam and laser driven plasma wakefield acceleration. A case of interest is the generation of a witness beam with 1 GeV energy, less than 1 mm-mrad slice emittance and 30 pC in 10 fs FWHM bunch length, which turns into 3 kA peak current at the undulator entrance. The witness beam has been successfully compressed down to 10 fs in a conventional SPARC-like photo-injector and boosted up to 500 MeV in an advanced high-gradient X-band linac reaching the plasma entrance with 3 kA peak current and the following RMS values: 0.06% energy spread, 0.5 mm-mrad transverse normalised emittance and a focal spot down to 1 $\mu m$. RF injector studies are here presented with the aim to satisfy the EuPRAXIA requests for the Design Study of a plasma-based user facility.Comment: 5 pages, 7 figures, European Advanced Accelerator Concepts 201

Focusing of high-brightness electron beams with active-plasma lenses

Plasma-based technology promises a tremendous reduction in size of accelerators used for research, medical, and industrial applications, making it possible to develop tabletop machines accessible for a broader scientific community. By overcoming current limits of conventional accelerators and pushing particles to larger and larger energies, the availability of strong and tunable focusing optics is mandatory also because plasma-accelerated beams usually have large angular divergences. In this regard, active-plasma lenses represent a compact and affordable tool to generate radially symmetric magnetic fields several orders of magnitude larger than conventional quadrupoles and solenoids. However, it has been recently proved that the focusing can be highly nonlinear and induce a dramatic emittance growth. Here, we present experimental results showing how these nonlinearities can be minimized and lensing improved. These achievements represent a major breakthrough toward the miniaturization of next-generation focusing devices

First single-shot and non-intercepting longitudinal bunch diagnostics for comb-like beam by means of Electro-Optic Sampling

At SPARC-LAB,we have installed an Electro-Optic Sampling(EOS)experiment for single shot,non- destructive measurements of the longitudinal distribution charge of individual electron bunches.The profile of the electron bunch field is electro-optically encoded into aTi:Sa laser, having 130fs(rms)pulse length, directly derived from the photocathode's laser. The bunch profile information is spatially retrieved,i.e.,the laser crosses with an angle of 30 degrees with respect to the normal to the surface of EO crystal(ZnTe,GaP)and the bunch longitudinal profile is mapped into the laser's transverse profile. In particular,we used the EOS for a single-shot direct visualization of the time profile of a comb-like electron beam,consisting of two bunches, about 100fs(rms)long,sub-picosecond spaced with a total charge of 160pC. The electro-optic measurements(done with both ZnTe and GaP crystals)have been validated with both RF Deflector (RFD)and Michelson interferometer measurements

The THz Radiation Source at the SPARC Facility

The interest for Terahertz (THz) radiation is rapidly growing, both as it is a powerful tool for investigating the behavior of matter at low energy, and as it allows for a number of possible spectroscopic applications spanning from medical science to security. The linacdriven THz source at the SPARC facility can deliver broadband THz pulses with femtosecond shaping and can be used for electron beam diagnostics to fully reconstruct the longitudinal charge distribution. Beyond this application, the possibility to store much more energy in a single THz pulse than table-top sources renders the SPARC THz source very interesting for a spectroscopic use. In addition, taking advantage from electron beam manipulation techniques, high power, narrow-band THz radiation can be also generated. Those source characteristics provide a unique chance to realize THz-pump/THz-probe spectroscopy, a technique practically unexplored up to now