Improving Information Retrieval in Multiwriter Scenario by Exploiting the Similarity Graph of Document Terms

This is the author accepted manuscript. The final version is available from IEEE via the DOI in this recordInformation Retrieval (IR) is the activity of obtaining information resources relevant to a questioned information. It usually retrieves a set of objects ranked according to the relevancy to the needed fact. In document analysis, information retrieval receives a lot of attention in terms of symbol and word spotting. However, through decades the community mostly focused either on printed or on single writer scenario, where the state-of-The-art results have achieved reasonable performance on the available datasets. Nevertheless, the existing algorithms do not perform accordingly on multiwriter scenario. A graph representing relations between a set of objects is a structure where each node delineates an individual element and the similarity between them is represented as a weight on the connecting edge. In this paper, we explore different analytics of graphs constructed from words or graphical symbols, such as diffusion, shortest path, etc. to improve the performance of information retrieval methods in multiwriter scenario.European Union Horizon 2020Ministerio de Educación, Cultura y Deporte, SpainFPUCERCA Programme/Generalitat de Cataluny

Prácticas audiovisuales: un método Feminista Nuevo Materialista para una investigación educativa

Este artículo explora cómo las prácticas audiovisuales se repiensan como método desde una perspectiva que se nutre de los Feminismos Nuevo Materialistas, el Giro Afectivo y los Métodos Visuales y Artísticos. Para examinar cómo funciona el método, se parte de una sesión enmarcada dentro del trabajo de campo del proyecto MiCreate. Esta sesión se lleva a cabo con un grupo de sexto de primaria en una escuela de Barcelona. A partir del caso de estudio, se deriva que filmar resulta una experiencia afectiva de conocimiento. Es un método situado en la experiencia que afecta al campo de estudio y, al mismo tiempo, se construye en su relación con él. Además, permite centrarse en los cuerpos, movimientos y afectos de la experiencia desde la parcialidad del visor. El método modifica los poderes de actuación de las investigadoras y participantes, habilitando respuestas y capacidades críticas afectivas y afirmativas para generar conocimiento en relación al método en sí mismo, la investigación y la experiencia contextualizada

Decoupling a tandem-repeat protein: Impact of multiple loop insertions on a modular scaffold

Abstract: The simple topology and modular architecture of tandem-repeat proteins such as tetratricopeptide repeats (TPRs) and ankyrin repeats makes them straightforward to dissect and redesign. Repeat-protein stability can be manipulated in a predictable way using site-specific mutations. Here we explore a different type of modification - loop insertion - that will enable a simple route to functionalisation of this versatile scaffold. We previously showed that a single loop insertion has a dramatically different effect on stability depending on its location in the repeat array. Here we dissect this effect by a combination of multiple and alternated loop insertions to understand the origins of the context-dependent loss in stability. We find that the scaffold is remarkably robust in that its overall structure is maintained. However, adjacent repeats are now only weakly coupled, and consequently the increase in solvent protection, and thus stability, with increasing repeat number that defines the tandem-repeat protein class is lost. Our results also provide us with a rulebook with which we can apply these principles to the design of artificial repeat proteins with precisely tuned folding landscapes and functional capabilities, thereby paving the way for their exploitation as a versatile and truly modular platform in synthetic biology

Testing the length limit of loop grafting in a helical repeat protein.

Alpha-helical repeat proteins such as consensus-designed tetratricopeptide repeats (CTPRs) are exceptionally stable molecules that are able to tolerate destabilizing sequence alterations and are therefore becoming increasingly valued as a modular platform for biotechnology and biotherapeutic applications. A simple approach to functionalize the CTPR scaffold that we are pioneering is the insertion of short linear motifs (SLiMs) into the loops between adjacent repeats. Here, we test the limits of the scaffold by inserting 17 highly diverse amino acid sequences of up to 58 amino acids in length into a two-repeat protein and examine the impact on protein folding, stability and solubility. The sequences include three SLiMs that bind oncoproteins and eleven naturally occurring linker sequences all predicted to be intrinsically disordered but with conformational preferences ranging from compact globules to expanded coils. We show that the loop-grafted proteins retain the native CTPR structure and are thermally stable with melting temperatures above 60 ​°C, despite the longest loop sequence being almost the same size as the CTPR scaffold itself (68 amino acids). Although the main determinant of the effect of stability was found to be loop length and was relatively insensitive to amino acid composition, the relationship between protein solubility and the loop sequences was more complex, with the presence of negatively charged amino acids enhancing the solubility. Our findings will help us to fully realize the potential of the repeat-protein scaffold, allowing a rational design approach to create artificial modular proteins with customized functional capabilities

Antropoestratigrafía: nuevas unidades litológicas del Cuaternario controladas por la actividad humana

Many areas around the world such as the Mediterranean region have been inhabited without interruption for thousands of years. This is the case of the city of Barcelona (Spain), where remains of human settlements dating from pre-Roman times until the present have been found. A detailed geological mapping of the area occupied by the city of Barcelona raises a number of questions about the Holocene stratigraphy affected by human activity. In the old urban and surrounding areas most of the sedimentary deposits accumulated during settlement result from human interactions. Thus, new anthropostratigraphic units are proposed. The sedimentary deposits and the infill of rock excavations due to human presence may be divided into three categories: Natural lithoanthropogenic units (NAU) when their formation is not directly affected by anthropogenic activity but these contain artefacts of human origin. Induced lithoanthropogenic units (IAU) when natural processes together with human actions produce sedimentation or erosion due to natural phenomena; Constructed lithoanthropogenic units (CAU) when sedimentary accumulations and sharp contacts result from direct human activity.A lo largo de todo el globo terrestre, existen muchas zonas como la región mediterránea que han sido habitadas ininterrumpidamente durante miles de años. Este es el caso de la ciudad de Barcelona donde se han encontrado restos de asentamientos humanos desde los tiempos pre-romanos hasta la actualidad. Un mapa geológico detallado de la zona ocupada por la ciudad de Barcelona plantea una serie de interrogantes sobre la estratigrafía del Holoceno influenciado por la actividad humana. En la zona urbana antigua y en áreas circundantes, la mayoría de los depósitos acumulados durante el asentamiento se han producido por las interacciones humanas. Por tanto, se proponen nuevas unidades antropoestratigráficas. Los depósitos sedimentarios así como los rellenos de lasexcavaciones debidos a la presencia humana pueden ser divididos en tres categorías: Unidades litoantropogénicas naturales (NAU) cuando su generación no ha sido afectada directamente por la actividad humana, pero contienen diversos artefactos artificiales. Unidades litoantropogénicas inducidas (IAU) cuando los procesos naturales junto a las acciones humanas producen sedimentación o erosión debido a los fenómenos naturales. Unidades litoantropogénicas construidas (CAU) cuando las acumulaciones sedimentarias y los contactos nítidos son el resultado de la actividad humana directa

Dissecting and reprogramming the folding and assembly of tandem-repeat proteins.

Studying protein folding and protein design in globular proteins presents significant challenges because of the two related features, topological complexity and co-operativity. In contrast, tandem-repeat proteins have regular and modular structures composed of linearly arrayed motifs. This means that the biophysics of even giant repeat proteins is highly amenable to dissection and to rational design. Here we discuss what has been learnt about the folding mechanisms of tandem-repeat proteins. The defining features that have emerged are: (i) accessibility of multiple distinct routes between denatured and native states, both at equilibrium and under kinetic conditions; (ii) different routes are favoured for folding compared with unfolding; (iii) unfolding energy barriers are broad, reflecting stepwise unravelling of an array repeat by repeat; (iv) highly co-operative unfolding at equilibrium and the potential for exceptionally high thermodynamic stabilities by introducing consensus residues; (v) under force, helical-repeat structures are very weak with non-co-operative unfolding leading to elasticity and buffering effects. This level of understanding should enable us to create repeat proteins with made-to-measure folding mechanisms, in which one can dial into the sequence the order of repeat folding, number of pathways taken, step size (co-operativity) and fine-structure of the kinetic energy barriers.We acknowledge funding from the Medical Research Council of the UK (grant G1002329) and the Leverhulme Trust. AP is funded by a BBSRC Doctoral Training Program studentship. LSI acknowledges support of a Fellowship from the Medical Research Foundation.This is the accepted manuscript. The final version is available at http://www.biochemsoctrans.org/content/43/5/881

Transformer modelling considering power losses using an inverse Jiles-Atherton approach

Power transformers are devices with non-linear behavior due to the saturation of the ferromagnetic core. When modelling such devices, the saturation effect must be taken into account because it greatly affects their performance and efficiency. In this paper, an electromagnetic model for power transformers is proposed and experimentally validated using an electrical T-model coupled with a reluctance network to model the magnetic part. The electrical circuit and the reluctance network are linked by two B–H approaches. The B–H relationships are modelled by the full hysteresis cycle based on the inverse Jiles-Atherton theory and by the initial magnetization curve. The results obtained with the inverse Jiles-Atherton theory model reproduce the magnetic core behavior with more accuracy than the one based on the initial magnetization curve, especially at low load conditions where saturation plays a more prominent role on the no-load current. The proposed model can be applied to other magnetic devices such as inductors for power electronic applications or electromechanical relays, among others.Peer ReviewedPostprint (published version

Olean (1, 7-dioxaspiro[5.5]undecane): A novel intraspecific chemical cue in coraebus undatus (f.) (coleoptera: Buprestidae)

The main aim of this work was to identify semiochemicals from the jewel beetle Coraebus undatus (F.) (Coleoptera: Buprestidae) that may aid in the improvement of current monitoring tools. First, HS-SPME collections revealed that individually sampled adults (>7 days old) of both sexes release the spiroacetal 1, 7-dioxaspiro[5.5]undecane (olean). Electroantennographic recordings from both sexes exposed to increasing amounts of olean followed a dose-dependent pattern, with females being more responsive than males to the highest amount of the compound (100 µg). In double-choice assays, adults older than seven days were significantly attracted to olean, whereas this attraction was not detected in insects aged less than seven days. Indeed, a repellent effect was observed in young females. Subsequent field trials employing sticky purple prism traps revealed that there were no differences among the number of insects caught in control and olean-baited traps at two different release rates (0.75 and 3.75 mg/day). Interestingly, all the trapped specimens were determined as mated females, regardless of the presence of olean. Overall, these findings provide a basis for unraveling the chemical ecology of the species, although further research is still needed to determine the specific role of this compound within the chemical communication of the species. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

depressive spectrum disorders in cancer prevalence risk factors and screening for depression a critical review

AbstractBackground: Although depression and mood-related disorders are common in persons with cancer, these conditions remain frequently overlooked in clinical practice. Negative consequences of depressive disorder spectrum have been reported (e.g. suicidal ideation, increase physical complications and somatic symptoms, negative influence on prognosis), indicating the need for routine screening, assessment and management.Methods: A search of the major databases (Medline, Embase, PsycLIT, PsycINFO, and the Cochrane Library) was conducted on the reviews and meta-analyses available in order to summarize relevant data concerning depressive disorders spectrum in terms of prevalence, risk factors, and screening and assessment among patients with cancer across the trajectory of the disease.Results: The data show a prevalence of depression and depressive disorders between 5% and 60% according to the different diagnostic criteria, the tools used in the studies (e.g. semi-structured psychiatric interview and psycho..