The National Immigrant Survey of Spain. A new data source for migration studies in Europe

Spain has recently become the destination for large numbers of international migrants and now ranks as a key focal point for international migration in Europe. Currently, approximately one in ten residents in Spain are foreigners, up more than tenfold from figures holding at the outset of this century. Migration has now become a major social and political issue in the country. In order to provide reliable data about migrants in Spain for researchers and policy makers, acting on a proposal of a research team working within the context of the Population and Society Research Network (GEPS), the Spanish Statistical Office has recently carried out an extremely ambitious survey of foreign-born persons currently living in Spain. In the course of the survey, nearly 15,500 persons were interviewed regarding a large array of issues pertaining to their migration experience. Important documentation, including the project report, the methodological specifications of the survey, and the anonymized micro data have recently been made available to the scientific community and to policy makers at the website of the Instituto Nacional de Estadística. The purpose of this paper is to describe this data source, its content, its methodological underpinnings, and the way the fieldwork and data cleaning were carried out. Examples of preliminary results will be presented so as to underscore the potential this survey affords for researchers everywhere.immigrant survey, international migration, migrant strategies, migration data set, migration studies, migratory networks, Spain

Development of predictive responses in theory of mind brain regions

When we watch movies, we consider the characters’ mental states in order to understand and predict the narrative. Recent work in fMRI uses movie-viewing paradigms to measure functional responses in brain regions recruited for such mental state reasoning (the Theory of Mind (“ToM”) network). Here, two groups of young children (n=30 3-4yo, n=26 6-7yo) viewed a short animated movie twice while undergoing fMRI. As children get older, ToM brain regions were recruited earlier in time during the second presentation of the movie. This “narrative anticipation” effect is specific: there was no such effect in a control network of brain regions that responds just as robustly to the movie (the “Pain Matrix”). These results complement prior studies in adults that suggest that ToM brain regions play a role not just in inferring, but in actively predicting, other people's thoughts and feelings, and provide novel evidence that as children get older, their ToM brain regions increasingly make such predictions. This is a post-peer-review, pre-copyedit version of an article published in Developmental Science. The final authenticated version is available online at: https://doi.org/10.1111/desc.12863

Variable climates lead to varying phenotypes: ‘weird’ mammalian torpor and lessons from non-Holarctic species

Mammalian heterotherms, species that employ short or long periods of torpor, are found in many different climatic regions. Although the underlying physiological mechanisms of heterothermy in species from lower latitudes (i.e. the tropics and southern hemisphere) appear analogous to those of temperate and arctic heterotherms, the ultimate triggers and resulting patterns of energy expenditure and body temperature are often noticeably different. Phenotypic flexibility in the patterns of thermoregulation in non-Holarctic species can be extensive (depending on body condition, environmental parameters and species competition) and the factors responsible for inducing heterothermy are more variable in non-Holarctic species. As well as being a regular adaptation to seasonality, heterothermy can also be employed as a response to unpredictability in environmental parameters and as a response to emergency situations. Non-Holarctic heterotherms also challenge the notion that regular inter-bout arousals during hibernation are obligatory and suggest all that is necessary to maintain proper functioning during hibernation is an occasional passive return to -or maintenance of - a relatively high body temperature. The study of non-Holarctic heterotherms has led to the conclusion that heterothermy must be defined on the basis of mechanistic, physiological parameters, and not solely by body temperature; yet we are still limited in our abilities to record such mechanistic parameters in the field. It is now believed that homeothermy in mammals evolved in hot climates via an ancestral heterothermic state. Similar to extant warm-climate heterotherms, early mammals could have relied mainly on passive body temperature regulation with a capacity for short- to longer-term up-regulation of metabolism when needed. Hibernation, as seen in temperate and arctic species may then be a derived state of this ancestral heterothermy, and the study of torpor in warm climates can provide potential models for the energetics of early mammals

The opinion‐policy nexus in Europe and the role of political institutions

A strong link between citizen preferences and public policy is one of the key goals and criteria of democratic governance. Yet, our knowledge about the extent to which public policies on specific issues are in line with citizen preferences in Europe is limited. This article reports on the first study of the link between public opinion and public policy that covers a large and diverse sample of concrete public policy issues in 31 European democracies. The findings demonstrate a strong positive relationship and a substantial degree of congruence between public opinion and the state of public policy. Also examined is whether political institutions, including electoral systems and the horizontal and vertical division of powers, influence the opinion-policy link. The evidence for such effects is very limited, which suggests that the same institutions might affect policy representation in countervailing ways through different mechanisms.NWOVIDI-452-12-008The politics and administration of institutional chang

MTSS1 is a critical epigenetically regulated tumor suppressor in CML

Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr-Abl mice and in patients with CML at diagnosis, and Mtss1 was restored when patients achieved complete remission. Forced expression of Mtss1 decreased clonogenic capacity and motility of murine myeloid progenitor cells and reduced tumor growth. Viral transduction of Mtss1 into lineage depleted SCLtTA/Bcr-Abl bone marrow cells decreased leukemic cell burden in recipients, and leukemogenesis was reduced upon injection of Mtss1 overexpressing murine myeloid 32D cells. Tyrosine kinase inhibitor (TKI) therapy and reversion of Bcr-Abl expression increased Mtss1 expression but failed to restore it to control levels. CML patient samples revealed higher DNA methylation of specific Mtss1 promoter CpG sites that contain binding sites for Kaiso and Rest transcription factors. In summary, we identified a novel tumor suppressor in CML stem cells that is downregulated by both Bcr-Abl kinase-dependent and -independent mechanisms. Restored Mtss1 expression markedly inhibits primitive leukemic cell biology in vivo, providing a therapeutic rationale for the Bcr-Abl-Mtss1 axis to target TKI resistant CML stem cells in patients

A systematic review on neutrophils interactions with titanium and zirconia surfaces: Evidence from in vitro studies

Objectives: This systematic review aimed to assess in vitro studies that evaluated neutrophil interactions with different roughness levels in titanium and zirconia implant surfaces. Material and Methods: An electronic search for literature was conducted on PubMed, Embase, Scopus, and Web of Science and a total of 14 studies were included. Neutrophil responses were assessed based on adhesion, cell number, surface coverage, cell structure, cytokine secretion, reactive oxygen species (ROS) production, neutrophil activation, receptor expression, and neutrophil extracellular traps (NETs) release. The method of assessing the risk of bias was done using the toxicological data reliability assessment tool (TOXRTOOL). Results: Ten studies have identified a significant increase in neutrophil functions, such as surface coverage, cell adhesion, ROS production, and NETs released when interacting with rough titanium surfaces. Moreover, neutrophil interaction with rough–hydrophilic surfaces seems to produce less proinflammatory cytokines and ROS when compared to naive smooth and rough titanium surfaces. Regarding membrane receptor expression, two studies have reported that the FcγIII receptor (CD16) is responsible for initial neutrophil adhesion to hydrophilic titanium surfaces. Only one study compared neutrophil interaction with titanium alloy and zirconia toughened alumina surfaces and reported no significant differences in neutrophil cell count, activation, receptor expression, and death. Conclusions: There are not enough studies to conclude neutrophil interactions with titanium and zirconia surfaces. However, different topographic modifications such as roughness and hydrophilicity might influence neutrophil interactions with titanium implant surfaces

Educational Strategies in Cultural Landscapes. Are we complying with the Faro Convention?

The Faro Convention underlined the importance of educational initiatives related to heritage. This paper focuses on the educational dimension of landscape, as a means to better facilitate its social acceptance and hence its inclusion in planning and management processes. The relation between landscape education and social perception, through a few European examples will be analysed to ascertain whether the principles of the Convention are being complied with effectively. The authors introduce four case studies of heritage-related education carried out in three European countries (Spain, Norway and Italy). These case studies provide the possibility to coherently analyse a wide range of activities and initiatives occurring at various scales and levels: geographic, local and sectoral. In addition, they describe the pedagogical potential of cultural landscapes and cultural heritage, and highlight some of the educational strategies and measures currently used in this field.Educational Strategies in Cultural Landscapes. Are we complying with the Faro Convention?publishedVersio

Limited Physiological Compensation in Response to an Acute Microclimate Change in a Malagasy Bat

Rapid environmental changes are challenging for endothermic species because they have direct and immediate impacts on their physiology by affecting microclimate and fundamental resource availability. Physiological flexibility can compensate for certain ecological perturbations, but our basic understanding of how species function in a given habitat and the extent of their adaptive scope is limited. Here we studied the effect of acute, experimental microclimate change on the thermal physiology of two populations of the widespread Malagasy bat, Macronycteris commersoni. Populations of this species are found roosting under contrasting conditions, i.e., in a constant hot and humid cave or below foliage unprotected from fluctuations in ambient conditions. We exposed free-ranging individuals of each population to the respective opposite condition and thus to novel microclimate within an ecologically realistic scope while measuring metabolic rate and skin temperature. Cave bats in forest setting had a limited capacity to maintain euthermia to the point that two individuals became hypothermic when ambient temperature dropped below their commonly experienced cave temperature. Forest bats on the other hand, had difficulties to dissipate heat in the humid cave set-up. The response to heat, however, was surprisingly uniform and all bats entered torpor combined with hyperthermia at temperatures exceeding their thermoneutral zone. Thus, while we observed potential for flexible compensation of heat through “hot” torpor, both populations showed patterns suggestive of limited potential to cope with acute microclimate changes deviating from their typically occupied roosts. Our study emphasizes that intraspecific variation among populations could be misleading when assessing species’ adaptive scopes, as variation may arise from genetic adaptation, developmental plasticity or phenotypic flexibility, all of which allow for compensatory responses at differing time scales. Disentangling these mechanisms and identifying the basis of variation is vital to make accurate predictions of species’ chances for persisting in ever rapidly changing habitats and climates