Reporting participation rates in studies of non-pharmacological interventions for patients with chronic obstructive pulmonary disease: a systematic review

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Development of a bedrest muscle stress apparatus

In attempting further to define the deleterious effects of spaceflight on the human body, measurement systems and techniques were devised to determine the loss of skeletal muscle strength and tone as a result of spaceflight exposure. In order to determine how the muscle degradation process progresses with time during nonuse, a system for measuring muscle stress during bedrest was developed. The Bedrest Muscle Stress Apparatus is configured to slip snugly over the foot board of a standard hospital bed. Data collected with this device correlated well with pre- and post-bedrest data collected with the original skeletal muscle stress apparatus

Towards low-latency real-time detection of gravitational waves from compact binary coalescences in the era of advanced detectors

Electromagnetic (EM) follow-up observations of gravitational wave (GW) events will help shed light on the nature of the sources, and more can be learned if the EM follow-ups can start as soon as the GW event becomes observable. In this paper, we propose a computationally efficient time-domain algorithm capable of detecting gravitational waves (GWs) from coalescing binaries of compact objects with nearly zero time delay. In case when the signal is strong enough, our algorithm also has the flexibility to trigger EM observation before the merger. The key to the efficiency of our algorithm arises from the use of chains of so-called Infinite Impulse Response (IIR) filters, which filter time-series data recursively. Computational cost is further reduced by a template interpolation technique that requires filtering to be done only for a much coarser template bank than otherwise required to sufficiently recover optimal signal-to-noise ratio. Towards future detectors with sensitivity extending to lower frequencies, our algorithm's computational cost is shown to increase rather insignificantly compared to the conventional time-domain correlation method. Moreover, at latencies of less than hundreds to thousands of seconds, this method is expected to be computationally more efficient than the straightforward frequency-domain method.Comment: 19 pages, 6 figures, for PR

Analytical and experimental study of the dynamics of a single-tube counterflow boiler

Experimental and analytical study of dynamics of single tube counterflow boile

High-Energy Neutrino Signatures of Dark Matter Decaying into Leptons

Decaying dark matter has previously been proposed as a possible explanation for the excess high energy cosmic ray electrons and positrons seen by PAMELA and the Fermi Gamma-Ray Space Telescope (FGST). To accommodate these signals however, the decays must be predominantly leptonic, to muons or taus, and therefore produce neutrinos, potentially detectable with the IceCube neutrino observatory. We find that, with five years of data, IceCube (supplemented by DeepCore) will be able to significantly constrain the relevant parameter space of decaying dark matter, and may even be capable of discovering dark matter decaying in the halo of the Milky Way.Comment: 4 pages, 1 figur

Neutrophil gelatinase-associated lipocalin: its response to hypoxia and association with acute mountain sickness.

Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility. Neutrophil gelatinase-associated lipocalin (NGAL) rises in response to renal injury, inflammation and oxidative stress. We investigated whether NGAL rises with HA and if this rise was related to AMS, hypoxia or exercise. NGAL was assayed in a cohort (n = 22) undertaking 6 hours exercise at near sea-level (SL); a cohort (n = 14) during 3 hours of normobaric hypoxia (FiO2 11.6%) and on two trekking expeditions (n = 52) to over 5000 m. NGAL did not change with exercise at SL or following normobaric hypoxia. During the trekking expeditions NGAL levels (ng/ml, mean ± sd, range) rose significantly (P < 0.001) from 68 ± 14 (60-102) at 1300 m to 183 ± 107 (65-519); 143 ± 66 (60-315) and 150 ± 71 (60-357) at 3400 m, 4270 m and 5150 m respectively. At 5150 m there was a significant difference in NGAL between those with severe AMS (n = 7), mild AMS (n = 16) or no AMS (n = 23): 201 ± 34 versus 171 ± 19 versus 124 ± 12 respectively (P = 0.009 for severe versus no AMS; P = 0.026 for mild versus no AMS). In summary, NGAL rises in response to prolonged hypobaric hypoxia and demonstrates a relationship to the presence and severity of AMS

Light emission through a corrugated metal film: The role of cross-coupled surface plasmon polaritons

S. Wedge, Ian R. Hooper, I. Sage, and William L. Barnes, Physical Review B, Vol. 69, article 245418 (2004). "Copyright © 2004 by the American Physical Society."We examine the phenomenon of light emission through a thin metal film that takes place via surface plasmon polaritons. Surface plasmon polariton cross coupling has recently been invoked to explain sharp features observed in the angle dependent emission spectra obtained from surface-emitting (through cathode) organic light-emitting diode structures. We investigated whether such a cross-coupling process is needed to explain such observations. We undertook measurements on samples for a variety of metal film thicknesses. Our results are consistent with the mechanism of surface plasmon polariton cross coupling but also show that the processes underlying the emission from such structures can be rather subtle

Non-Thermal Dark Matter Mimicking An Additional Neutrino Species In The Early Universe

The South Pole Telescope (SPT), Atacama Cosmology Telescope (ACT), and Wilkinson Microwave Anisotropy Probe (WMAP) have each reported measurements of the cosmic microwave background's (CMB) angular power spectrum which favor the existence of roughly one additional neutrino species, in addition to the three contained in the standard model of particle physics. Neutrinos influence the CMB by contributing to the radiation density, which alters the expansion rate of the universe during the epoch leading up to recombination. In this paper, we consider an alternative possibility that the excess kinetic energy implied by these measurements was possessed by dark matter particles that were produced through a non-thermal mechanism, such as late-time decays. In particular, we find that if a small fraction (<1%) of the dark matter in the universe today were produced through the decays of a heavy and relatively long-lived state, the expansion history of the universe can be indistinguishable from that predicted in the standard cosmological model with an additional neutrino. Furthermore, if these decays take place after the completion of big bang nucleosynthesis, this scenario can avoid tension with the value of three neutrino species preferred by measurements of the light element abundances.Comment: 5 pages, 2 figure

Why Compact Tori For Fusion?

A compact torus (CT) has a toroidal magnetic and plasma geometry, but is contained within a simply-connected vacuum vessel such as a cylinder. Spheromaks and field-reversed configurations fall into this category. Compact tori are translatable and have a high engineering beta. The primary benefit of CTs for fusion is the absence of toroidal field and Ohmic Heating coils and the many problems brought on by them. Studying fusion-relevant plasma in simply-connected geometries affords the world fusion program both physics and technology opportunities not found in other configurations. This paper outlines the technology and physics opportunities of compact tori, and presents a cost model based on geometry for comparison with less compact configurations