Perfect design or practical study? A workshop on navigating the challenges of community based prevention research

Subject: There is a shared interest among public health researchers in tackling methodological issues surrounding community based research, and on moving beyond a focus on individual level change. As part of a project on community empowerment funded by the People’s Health Trust, we have conducted a feasibility study on quantitative and economic evaluation of complex community-based interventions. To understand different quantitative methods that can be used to evaluate community empowerment interventions, we have undertaken a methodological literature review that identified the following sets of challenges: Defining population of interest – interventions taking place at a community level are not specifically targeted at a well-defined group of individuals. Therefore it is challenging to even find those who are affected by an intervention. Diverse and un-prescribed effects – the effect of community empowerment interventions are likely broad, suggesting we need to measure multiple outcomes in order to detect change. This increases the likelihood of detecting spurious change and can require a lot of resource. Furthermore, in many cases these outcomes are not pre-defined by a programme (i.e. communities choose their own foci)

Rheology of Lava Flows on Europa and the Emergence of Cryovolcanic Domes

There is ample evidence that Europa is currently geologically active. Crater counts suggest that the surface is no more than 90 Myr old, and cryovolcanism may have played a role in resurfacing the satellite in recent geological times. Europa's surface exhibits many putative cryovolcanic features, and previous investigations have suggested that a number of domes imaged by the Galileo spacecraft may be volcanic in origin. Consequently, several Europa domes have been modeled as viscous effusions of cryolava. However, previous models for the formation of silicic domes on the terrestrial planets contain fundamental shortcomings. Many of these shortcomings have been alleviated in our new modeling approach, which warrants a re-assessment of the possibility of cryovolcanic domes on Europa

Emplacement of Volcanic Domes on Venus and Europa

Placing firmer constraints on the emplacement timescales of visible volcanic features is essential to obtaining a better understanding of the resurfacing history of Venus. Fig. 1 shows a Magellan radar image and topography for a putative venusian lava dome. 175 such domes have been identified, having diameters that range from 19 - 94 km, and estimated thicknesses as great as 4 km [1-2]. These domes are thought to be volcanic in origin [3], having formed by the flow of a viscous fluid (i.e., lava) onto the surface. Among the unanswered questions surrounding the formation of Venus steep-sided domes are their emplacement duration, composition, and the rheology of the lava. Rheologically speaking, maintenance of extremely thick, 1-4 km flows necessitates higher viscosity lavas, while the domes' smooth upper surfaces imply the presence of lower viscosity lavas [2-3]. Further, numerous quantitative issues, such as the nature and duration of lava supply, how long the conduit remained open and capable of supplying lava, the volumetric flow rate, and the role of rigid crust in influencing flow and final morphology all have implications for subsurface magma ascent and local surface stress conditions. The surface of Jupiter's icy moon Europa exhibits many putative cryovolcanic constructs [5-7], and previous workers have suggested that domical positive relief features imaged by the Galileo spacecraft may be volcanic in origin [5,7-8] (Fig. 2). Though often smaller than Venus domes, if emplaced as a viscous fluid, formation mechanisms for europan domes may be similar to those of venusian domes [7]. Models for the emplacement of venusian lava domes (e.g. [9-10]) have been previously applied to the formation of putative cryolava domes on Europa [7]

Importance of Geodetically Controlled Topography to Constrain Rates of Volcanism and Internal Magma Plumbing Systems

Investigation of lava flow deposits is a key component of Investigation II.A.1 in the VEXAG Goals, Objectives and Investigations. Because much of the Venus surface is covered in lava flows, characterization of lava flow emplacement conditions(eruption rate and eruption duration) is critical for understanding the mechanisms through which magma is stored and released onto the surface as well as for placing constraints on rates of volcanic resurfacing throughout the geologic record preserved at the surface

A discrete slug population model determined by egg production

Slugs are significant pests in agriculture (as well as a nuisance to gardeners), and it is therefore important to understand their population dynamics for the construction of efficient and effective control measures. Differential equation models of slug populations require the inclusion of large (variable) temporal delays, and strong seasonal forcing results in a non-autonomous system. This renders such models open to only a limited amount of rigorous analysis. In this paper, we derive a novel batch model based purely upon the quantity of eggs produced at different times of the year. This model is open to considerable reduction; from the resulting two variable discrete-time system it is possible to reconstruct the dynamics of the full population across the year and give conditions for extinction or global stability and persistence. Furthermore, the steady state temporal population distribution displays qualitatively different behavior with only small changes in the survival probability of slugs. The model demonstrates how small variations in the favorability of different years may result in widely different slug population fluctuations between consecutive years, and is in good agreement with field data

Reduction of leukocyte microvascular adherence and preservation of blood-brain barrier function by superoxide-lowering therapies in a piglet model of neonatal asphyxia

Background: Asphyxia is the most common cause of brain damage in newborns. Substantial evidence indicates that leukocyte recruitment in the cerebral vasculature during asphyxia contributes to this damage. We tested the hypothesis that superoxide radical (O2⋅_) promotes an acute post-asphyxial inflammatory response and blood-brain barrier (BBB) breakdown. We investigated the effects of removing O2⋅_ by superoxide dismutase (SOD) or C3, the cell-permeable SOD mimetic, in protecting against asphyxia-related leukocyte recruitment. We also tested the hypothesis that xanthine oxidase activity is one source of this radical.Methods: Anesthetized piglets were tracheostomized, ventilated, and equipped with closed cranial windows for the assessment of post-asphyxial rhodamine 6G-labeled leukocyte-endothelial adherence and microvascular permeability to sodium fluorescein in cortical venules. Asphyxia was induced by discontinuing ventilation. SOD and C3 were administered by cortical superfusion. The xanthine oxidase inhibitor oxypurinol was administered intravenously.Results: Leukocyte-venular adherence significantly increased during the initial 2 h of post-asphyxial reperfusion. BBB permeability was also elevated relative to non-asphyxial controls. Inhibition of O2⋅_ production by oxypurinol, or elimination of O2⋅_ by SOD or C3, significantly reduced rhodamine 6G-labeled leukocyte-endothelial adherence and improved BBB integrity, as measured by sodium fluorescein leak from cerebral microvessels.Conclusion: Using three different strategies to either prevent formation or enhance elimination of O2⋅_ during the post-asphyxial period, we saw both reduced leukocyte adherence and preserved BBB function with treatment. These findings suggest that agents which lower O2⋅_ in brain may be attractive new therapeutic interventions for the protection of the neonatal brain following asphyxia

Annotated bibliography 1986-1990

The following compilation represents the third installment of Oral Tradition's ongoing annotated bibliography of scholarship relevant to the field. This addition, covering the years 1986-1990, maintains the goals of the first two installments: 1) to update John Miles Foley's original bibliography, Oral-Formulaic Theory and Research (Garland 1985), which provided an annotated listing of scholarship on the Parry-Lord theory of oral composition up until 1982, and 2) to expand the scope of the bibliography into other fields related to the study of oral traditions. The initial year of this installment also marks the beginning of Oral Tradition itself, and all articles published in the journal from 1986-1990 are herein annotated.Not