Measurement of distributed strain and temperature based on higher order and higher mode Bragg conditions

A Bragg grating sensor for measuring distributed strain and temperature at the same time comprises an optical fiber having a single mode operating wavelength region and below a cutoff wavelength of the fiber having a multimode operating wavelength region. A saturated, higher order Bragg grating having first and second order Bragg conditions is fabricated in the optical fiber. The first order of Bragg resonance wavelength of the Bragg grating is within the single mode operating wavelength region of the optical fiber and the second order of Bragg resonance wavelength is below the cutoff wavelength of the fiber within the multimode operating wavelength region. The reflectivities of the saturated Bragg grating at the first and second order Bragg conditions are less than two orders of magnitude of one another. In use, the first and second order Bragg conditions are simultaneously created in the sensor at the respective wavelengths and a signal from the sensor is demodulated with respect to each of the wavelengths corresponding to the first and second order Bragg conditions. Two Bragg conditions have different responsivities to strain and temperature, thus allowing two equations for axial strain and temperature to be found in terms of the measure shifts in the primary and second order Bragg wavelengths. This system of equations can be solved for strain and temperature

The Need for Kaizen Culture for Manufacturing Industries in Industry 4.0

Purpose: The study aims to find the need for creativity in industry 4.0, To test whether creativity can be embraced by Kaizen.   Theoretical framework: The problem statement is does Kaizen / Creativity to be extended to industry 4.0 and the same is researched with Literature reviews and with a set of Hypotheses.   Design/methodology/approach: Survey questions were framed to check the linkage of creativity and industry 4.0, two hypotheses was tested, 30 samples from Experts in Industry and Academia contributed to the thoughts, and Correlations and SEM were used to conclude the findings.   Findings: SPSS was used and principal component analysis with a “t” test was done to look at the correlation of independent variables to the above-mentioned hypothesis, the results revealed that there is a significant relationship with, effective communication, open innovation, Continuous Improvement, transformational leadership, collaboration, Goal clarity team autonomy, attitude, and knowledge enhancement.   Research, Practical & Social implications: The sample size is less and can need to be tested on a larger sample size. The study can also be done in employees in industry 3.0 and industry 4.0 to check the effects. The practical implications is well tested in Industry 2.0 and Industry 3.0 The same needs to be continued for industry 4.0 to induce creativity thereby knowledge enhancement and Team Autonomy. Considering human behaviour this closed loop of problems. Kaizens is needed to sustain the innovation and thereby creating a culture of involvement and ownership.   Originality/Value: There is active research in present times, researchers are showing keen interest on convincing the needs and benefits of Industry 4.0, but the behavioural aspect and its implications with industry 4.0 need to be explored. The next generation i.e. industry 4.0 will be more challenging, as there would be the challenge of a skilled workforce, and pressure for time/productivity will be high. People will be working in isolation (Sharing of thoughts and ideas will be limited Stalling of thinking approach). This may lead to psychological problems.The present study contributes to bridge this research gap

Concepts in marine biotechnology and their applications for enhancing aquaculture productivity

Application of biotechnology techniques to agriculture increased the quality and quantity of the final yield. Genetic engineering applied to the production of fish, molluscs and crustaceans although at the rudimentary stage offers promise. Besides, other techniques like tissue culture, chromosomal engineering, cryopreservation of embryos, and production of transgenic organisms also offer immense scope to expand and improve aquaculture operations

A 3D Morphable Model learnt from 10,000 faces

We present Large Scale Facial Model (LSFM) — a 3D Morphable Model (3DMM) automatically constructed from 9,663 distinct facial identities. To the best of our knowledge LSFM is the largest-scale Morphable Model ever constructed, containing statistical information from a huge variety of the human population. To build such a large model we introduce a novel fully automated and robust Morphable Model construction pipeline. The dataset that LSFM is trained on includes rich demographic information about each subject, allowing for the construction of not only a global 3DMM but also models tailored for specific age, gender or ethnicity groups. As an application example, we utilise the proposed model to perform age classification from 3D shape alone. Furthermore, we perform a systematic analysis of the constructed 3DMMs that showcases their quality and descriptive power. The presented extensive qualitative and quantitative evaluations reveal that the proposed 3DMM achieves state-of-the-art results, outperforming existing models by a large margin. Finally, for the benefit of the research community, we make publicly available the source code of the proposed automatic 3DMM construction pipeline. In addition, the constructed global 3DMM and a variety of bespoke models tailored by age, gender and ethnicity are available on application to researchers involved in medically oriented research

A 3D morphable model learnt from 10,000 faces

This is the final version of the article. It is the open access version, provided by the Computer Vision Foundation. Except for the watermark, it is identical to the IEEE published version. Available from IEEE via the DOI in this record.We present Large Scale Facial Model (LSFM) - a 3D Morphable Model (3DMM) automatically constructed from 9,663 distinct facial identities. To the best of our knowledge LSFM is the largest-scale Morphable Model ever constructed, containing statistical information from a huge variety of the human population. To build such a large model we introduce a novel fully automated and robust Morphable Model construction pipeline. The dataset that LSFM is trained on includes rich demographic information about each subject, allowing for the construction of not only a global 3DMM but also models tailored for specific age, gender or ethnicity groups. As an application example, we utilise the proposed model to perform age classification from 3D shape alone. Furthermore, we perform a systematic analysis of the constructed 3DMMs that showcases their quality and descriptive power. The presented extensive qualitative and quantitative evaluations reveal that the proposed 3DMM achieves state-of-the-art results, outperforming existing models by a large margin. Finally, for the benefit of the research community, we make publicly available the source code of the proposed automatic 3DMM construction pipeline. In addition, the constructed global 3DMM and a variety of bespoke models tailored by age, gender and ethnicity are available on application to researchers involved in medically oriented research.J. Booth is funded by an EPSRC DTA from Imperial College London, and holds a Qualcomm Innovation Fellowship. A. Roussos is funded by the Great Ormond Street Hospital Childrens Charity (Face Value: W1037). The work of S. Zafeiriou was partially funded by the EPSRC project EP/J017787/1 (4D-FAB)

Structural Biology of the Enterovirus Replication-Linked 5\u27-Cloverleaf RNA and associated Virus Proteins

Although enteroviruses are associated with a wide variety of diseases and conditions, their mode of replication is well conserved. Their genome is carried as a single, positive-sense RNA strand. At the 5′ end of the strand is an approximately 90-nucleotide self-complementary region called the 5′ cloverleaf, or the oriL. This noncoding region serves as a platform upon which host and virus proteins, including the 3B, 3C, and 3D virus proteins, assemble in order to initiate replication of a negative-sense RNA strand. The negative strand in turn serves as a template for synthesis of multiple positive-sense RNA strands. Building on structural studies of individual RNA stem-loops, the structure of the intact 5′ cloverleaf from rhinovirus has recently been determined via nuclear magnetic resonance/small-angle X-ray scattering (NMR/SAXS)-based methods, while structures have also been determined for enterovirus 3A, 3B, 3C, and 3D proteins. Analysis of these structures, together with structural and modeling studies of interactions between host and virus proteins and RNA, has begun to provide insight into the enterovirus replication mechanism and the potential to inhibit replication by blocking these interactions

Successful transportation of wild stock of endangered "Thooli" (Labeo dussumieri) spawners without anaesthetics

Several problems are encountered during transportation of fishes from wild to captivity. The note describes successful transportation of wild caught endangered Labeo dussumieri spawners over distances below 100 km without anesthesia or sophisticated transporting devices which is of immense help in the gene banking programme of endangered species

pH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain

Prostate apoptosis response-4 (Par-4) is a 38 kDa largely intrinsically disordered tumor suppressor protein that functions in cancer cell apoptosis. Par-4 down-regulation is often observed in cancer while up-regulation is characteristic of neurodegenerative conditions such as Alzheimer’s disease. Cleavage of Par-4 by caspase-3 activates tumor suppression via formation of an approximately 25 kDa fragment (cl-Par-4) that enters the nucleus and inhibits Bcl-2 and NF-ƙB, which function in pro-survival pathways. Here, we have investigated the structure of cl-Par-4 using biophysical techniques including circular dichroism (CD) spectroscopy, dynamic light scattering (DLS), and intrinsic tyrosine fluorescence. The results demonstrate pH-dependent folding of cl-Par-4, with high disorder and aggregation at neutral pH, but a largely folded, non-aggregated conformation at acidic p

Conformational Flexibility in the Enterovirus RNA Replication Platform

A presumed RNA cloverleaf (5′CL), located at the 5′-most end of the noncoding region of the enterovirus genome, is the primary established site for initiation of genomic replication. Stem–loop B (SLB) and stem–loop D (SLD), the two largest stem–loops within the 5′CL, serve as recognition sites for protein interactions that are essential for replication. Here we present the solution structure of rhinovirus serotype 14 5′CL using a combination of nuclear magnetic resonance spectroscopy and small-angle X-ray scattering. In the absence of magnesium, the structure adopts an open, somewhat extended conformation. In the presence of magnesium, the structure compacts, bringing SLB and SLD into close contact, a geometry that creates an extensive accessible major groove surface, and permits interaction between the proteins that target each stem–loop