Design of a high power production target for the Beam Dump Facility at CERN

The Beam Dump Facility (BDF) project is a proposed general-purpose facility at CERN, dedicated to beam dump and fixed target experiments. In its initial phase, the facility is foreseen to be exploited by the Search for Hidden Particles (SHiP) experiment. Physics requirements call for a pulsed 400 GeV/c proton beam as well as the highest possible number of protons on target (POT) each year of operation, in order to search for feebly interacting particles. The target/dump assembly lies at the heart of the facility, with the aim of safely absorbing the full high intensity Super Proton Synchrotron (SPS) beam, while maximizing the production of charmed and beauty mesons. High-Z materials are required for the target/dump, in order to have the shortest possible absorber and reduce muon background for the downstream experiment. The high average power deposited on target (305 kW) creates a challenge for heat removal. During the BDF facility Comprehensive Design Study (CDS), launched by CERN in 2016, extensive studies have been carried out in order to define and assess the target assembly design. These studies are described in the present contribution, which details the proposed design of the BDF production target, as well as the material selection process and the optimization of the target configuration and beam dilution. One of the specific challenges and novelty of this work is the need to consider new target materials, such as a molybdenum alloy (TZM) as core absorbing material and Ta2.5W as cladding. Thermo-structural and fluid dynamics calculations have been performed to evaluate the reliability of the target and its cooling system under beam operation. In the framework of the target comprehensive design, a preliminary mechanical design of the full target assembly has also been carried out, assessing the feasibility of the whole target system.Comment: 17 pages, 18 figure

New Results from the Cryogenic Dark Matter Search Experiment

Using improved Ge and Si detectors, better neutron shielding, and increased counting time, the Cryogenic Dark Matter Search (CDMS) experiment has obtained stricter limits on the cross section of weakly interacting massive particles (WIMPs) elastically scattering from nuclei. Increased discrimination against electromagnetic backgrounds and reduction of neutron flux confirm WIMP-candidate events previously detected by CDMS were consistent with neutrons and give limits on spin-independent WIMP interactions which are >2X lower than previous CDMS results for high WIMP mass, and which exclude new parameter space for WIMPs with mass between 8-20 GeV/c^2.Comment: 4 pages, 4 figure

Exclusion limits on the WIMP-nucleon cross-section from the Cryogenic Dark Matter Search

The Cryogenic Dark Matter Search (CDMS) employs low-temperature Ge and Si detectors to search for Weakly Interacting Massive Particles (WIMPs) via their elastic-scattering interactions with nuclei while discriminating against interactions of background particles. For recoil energies above 10 keV, events due to background photons are rejected with >99.9% efficiency, and surface events are rejected with >95% efficiency. The estimate of the background due to neutrons is based primarily on the observation of multiple-scatter events that should all be neutrons. Data selection is determined primarily by examining calibration data and vetoed events. Resulting efficiencies should be accurate to about 10%. Results of CDMS data from 1998 and 1999 with a relaxed fiducial-volume cut (resulting in 15.8 kg-days exposure on Ge) are consistent with an earlier analysis with a more restrictive fiducial-volume cut. Twenty-three WIMP candidate events are observed, but these events are consistent with a background from neutrons in all ways tested. Resulting limits on the spin-independent WIMP-nucleon elastic-scattering cross-section exclude unexplored parameter space for WIMPs with masses between 10-70 GeV c^{-2}. These limits border, but do not exclude, parameter space allowed by supersymmetry models and accelerator constraints. Results are compatible with some regions reported as allowed at 3-sigma by the annual-modulation measurement of the DAMA collaboration. However, under the assumptions of standard WIMP interactions and a standard halo, the results are incompatible with the DAMA most likely value at >99.9% CL, and are incompatible with the model-independent annual-modulation signal of DAMA at 99.99% CL in the asymptotic limit.Comment: 40 pages, 49 figures (4 in color), submitted to Phys. Rev. D; v.2:clarified conclusions, added content and references based on referee's and readers' comments; v.3: clarified introductory sections, added figure based on referee's comment

A facility to Search for Hidden Particles (SHiP) at the CERN SPS

A new general purpose fixed target facility is proposed at the CERN SPS accelerator which is aimed at exploring the domain of hidden particles and make measurements with tau neutrinos. Hidden particles are predicted by a large number of models beyond the Standard Model. The high intensity of the SPS 400~GeV beam allows probing a wide variety of models containing light long-lived exotic particles with masses below ${\cal O}$(10)~GeV/c$^2$, including very weakly interacting low-energy SUSY states. The experimental programme of the proposed facility is capable of being extended in the future, e.g. to include direct searches for Dark Matter and Lepton Flavour Violation.Comment: Technical Proposa

Systematics in the Gamma Ray Bursts Hubble diagram

Thanks to their enormous energy release which allows to detect them up to very high redshift, Gamma Rays Bursts (GRBs) have recently attracted a lot of interest to probe the Hubble diagram (HD) deep into the matter dominated era and hence complement Type Ia Supernoave (SNeIa). However, lacking a local GRBs sample, calibrating the scaling relations proposed as an equivalent to the Phillips law to standardize GRBs is not an easy task because of the need to estimate the GRBs luminosity distance in a model independent way. We consider here three different calibration methods based on the use of a fiducial $\Lambda$CDM model, on cosmographic parameters and on the local regression on SNeIa. We find that the calibration coefficients and the intrinsic scatter do not significantly depend on the adopted calibration procedure. We then investigate the evolution of these parameters with the redshift finding no statistically motivated improvement in the likelihood so that the no evolution assumption is actually a well founded working hypothesis. Under this assumption, we then consider possible systematics effects on the HDs introduced by the calibration method, the averaging procedure and the homogeneity of the sample arguing against any significant bias. We nevertheless stress that a larger GRBs sample with smaller uncertainties is needed to definitely conclude that the different systematics considered here have indeed a negligible impact on the HDs thus strengthening the use of GRBs as cosmological tools.Comment: 14 pages, 1 figure, 6 table

Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells.

Although it is well known that RET gene is strongly activated by retinoic acid (RA) in neuroblastoma cells, the mechanisms underlying such activation are still poorly understood. Here we show that a complex series of molecular events, that include modifications of both chromatin and DNA methylation state, accompany RA-mediated RET activation. Our results indicate that the primary epigenetic determinants of RA-induced RET activation differ between enhancer and promoter regions. At promoter region, the main mark of RET activation was the increase of H3K4me3 levels while no significant changes of the methylation state of H3K27 and H3K9 were observed. At RET enhancer region a bipartite chromatin domain was detected in unstimulated cells and a prompt demethylation of H3K27me3 marked RET gene activation upon RA exposure. Moreover, ChIP experiments demonstrated that EZH2 and MeCP2 repressor complexes were associated to the heavily methylated enhancer region in the absence of RA while both complexes were displaced during RA stimulation. Finally, our data show that a demethylation of a specific CpG site at the enhancer region could favor the displacement of MeCP2 from the heavily methylated RET enhancer region providing a novel potential mechanism for transcriptional regulation of methylated RA-regulated loci

Exclusion Limits on the WIMP-Nucleon Cross-Section from the First Run of the Cryogenic Dark Matter Search in the Soudan Underground Lab

The Cryogenic Dark Matter Search (CDMS-II) employs low-temperature Ge and Si detectors to seek Weakly Interacting Massive Particles (WIMPs) via their elastic scattering interactions with nuclei. Simultaneous measurements of both ionization and phonon energy provide discrimination against interactions of background particles. For recoil energies above 10 keV, events due to background photons are rejected with >99.99% efficiency. Electromagnetic events very near the detector surface can mimic nuclear recoils because of reduced charge collection, but these surface events are rejected with >96% efficiency by using additional information from the phonon pulse shape. Efficient use of active and passive shielding, combined with the the 2090 m.w.e. overburden at the experimental site in the Soudan mine, makes the background from neutrons negligible for this first exposure. All cuts are determined in a blind manner from in situ calibrations with external radioactive sources without any prior knowledge of the event distribution in the signal region. Resulting efficiencies are known to ~10%. A single event with a recoil of 64 keV passes all of the cuts and is consistent with the expected misidentification rate of surface-electron recoils. Under the assumptions for a standard dark matter halo, these data exclude previously unexplored parameter space for both spin-independent and spin-dependent WIMP-nucleon elastic scattering. The resulting limit on the spin-independent WIMP-nucleon elastic-scattering cross-section has a minimum of 4x10^-43 cm^2 at a WIMP mass of 60 GeV/c^2. The minimum of the limit for the spin-dependent WIMP-neutron elastic-scattering cross-section is 2x10^-37 cm^2 at a WIMP mass of 50 GeV/c^2.Comment: 37 pages, 42 figure

Dinámica de aguas superficiales de tres períodos continuos de Landsat; diferencias subregionales en llanuras argentinas

[EN] The Pampean region in Argentina is an extensive plain characterized by abundant shallow lakes that fulfill many environmental, ecological, and social functions. This study aims to detect the multiannual lake area changes in this region during 2001-2009 using remote sensing, including lakes as small as ≥10,000 m2 or 1 ha. Landsat scenes of the wet (2008-2009), normal (2006), and dry (2008-2009) seasons were obtained, and using remote sensing techniques, the number and area of shallow lakes were calculated. The spatiotemporal variation of shallow lakes was studied in different climate periods in eight singular subregions. Spatial associations between annual precipitation and lake number and area were analyzed through the development of a Geographic Information System (GIS) at a subregional scale. During the study period the total lake area in the Pampean region decreased by 5257.39 km2 (62 %), but each subregion showed different responses to climatic events. In seven of them, the differences between climate periods prove to be statistically significant (P>0.01). The relationship between precipitation and lake number and area revealed the domain of positive association. We conclude that climate factors play a dominant role in lake changes across the Pampean plains. However, other factors such as origin, topographic and edaphic characteristics intensify or mitigate changes in surface hydrology.[ES] La Región Pampeana en Argentina es una extensa planicie caracterizada por abundantes lagunas que cumplen numerosas funciones ambientales, ecológicas y sociales. Este estudio tiene como objetivo detectar los cambios plurianuales del área lagunar en esta región durante el período 2001-2009 utilizando la teledetección, incluidos lagos tan pequeños como ≥ 10.000 m2 o 1 ha. Se obtuvieron escenas Landsat de las estaciones húmeda (2008-2009), normal (2006) y seca (2008-2009) y, mediante técnicas de teledetección, se calculó el número y el área de las lagunas. Se estudió su variación espacio-temporal en diferentes períodos climáticos en ocho subregiones singulares. Se analizaron las correlaciones espaciales entre la precipitación anual y el número y el área de los lagos mediante el desarrollo de un Sistema de Información Geográfica (SIG). Durante el período de estudio el área total de lagos en la región pampeana disminuyó en 5.257,39  km2 (62 %), pero cada subregión mostró diferentes respuestas a los eventos climáticos. En siete de ellos, las diferencias entre periodos climáticos resultan estadísticamente significativas (P>0,01). La relación entre la precipitación con el número y área de las lagunas reveló el dominio de asociaciones positivas. Si bien el clima juega un papel dominante en los cambios en las lagunas de planicie, otros factores, como el origen, las características topográficas y edáficas, intensifican o mitigan los cambios en la hidrología superficial.Authors would like to thank the Consejo Nacional de Investigaciones Científicas y Técnicas for supporting this study. Besides, to the United States Geological Survey for supplying the information analyzed in this study. This work was carried out with the aid of a grant from the Inter-American Institute for Global Change Research (IAI) CRN3038, which is supported by the US National Science Foundation (Grant GEO-1128040)Aliaga, VS.; Piccolo, M.; Perillo, G. (2021). Surface water extent dynamics from three periods of continuous Landsat time series; subregional differences across Argentine plains. Revista de Teledetección. 0(58):131-145. http://hdl.handle.net/10251/169769OJS13114505

Non-Linearity in Ecosystem Services: Temporal and Spatial Variability in Coastal Protection

Natural processes tend to vary over time and space, as well as between species. The ecosystem services these natural processes provide are therefore also highly variable. It is often assumed that ecosystem services are provided linearly (unvaryingly, at a steady rate), but natural processes are characterized by thresholds and limiting functions. In this paper, we describe the variability observed in wave attenuation provided by marshes, mangroves, seagrasses, and coral reefs and therefore also in coastal protection. We calculate the economic consequences of assuming coastal protection to be linear. We suggest that, in order to refine ecosystem-based management practices, it is essential that natural variability and cumulative effects be considered in the valuation of ecosystem services

Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells

Introduction Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function of galectin-1 and galectin-9 (Gal-1, Gal-9) in dendritic cells (DCs) from patients with AITD. Materials and Methods Peripheral blood samples from 25 patients with Graves’ disease (GD), 11 Hashimoto’s thyroiditis (HT), and 24 healthy subjects were studied. Thyroid tissue samples from 44 patients with AITD and 22 patients with goiter were also analyzed. Expression and function of Gal-1 and Gal-9 was assessed by quantitative RT-PCR, immunofluorescence and flow cytometry. Results A diminished expression of Gal-9, but not of Gal-1, by peripheral blood DCs was observed in GD patients, mainly in those with Graves´ ophthalmopathy, and a significant negative association between disease severity and Gal-9 expression was detected. In addition, the mRNA levels of Gal-9 and its ligand TIM-3 were increased in thyroid tissue from AITD patients and its expression was associated with the levels of Th1/Th12/Th17 cytokines. Immunofluorescence studies proved that intrathyroidal Gal-9 expression was confined to DCs and macrophages. Finally, in vitro functional assays showed that exogenous Gal-9 had a suppressive effect on the release of Th1/Th2/Th17 cytokines by DC/lymphocyte autologous co-cultures from both AITD patients and healthy controls. Conclusions The altered pattern of expression of Gal-9 in peripheral blood DCs from GD patients, its correlation with disease severity as well as its ability to suppress cytokine release suggest that Gal-9 could be involved in the pathogenesis of AITDThis work was supported by grants from the Fondo de Investigaciones Sanitarias (FISS) PI10/ 02521 and S2010/BMD-2328 TIRONET (Comunidad de Madrid), Spain (to MM) and the Fondo de Cooperación Internacional en Ciencia y Tecnología (FONCICYT) 95395, European Union-México (to RGA