504 research outputs found
Renormalizability of Massive Gravity in Three Dimensions
We discuss renormalizability of a recently established, massive gravity
theory with particular higher derivative terms in three space-time dimensions.
It is shown that this massive gravity is certainly renormalizable as well as
unitary, so it gives us a physically interesting toy model of perturbative
quantum gravity in three dimensions.Comment: 13 pages, no figure
Организационные резервы повышения производительности труда на предприятиях нефтегазовой отрасли
Проблема повышения производительности труда в современной экономике России имеет значительную актуальность, поскольку повышение уровня производительности труда является важнейшим условием социально-экономического развития общества, устойчивого экономического роста и повышения конкурентоспособности национальной экономики. Актуальность представленного исследования определяется необходимостью повышения производительности труда на современных предприятиях России, что может быть достигнуто за счет реализации организационных резервов роста. Целью исследования является структурирование факторов, оказывающих влияние на уровень производительности труда, подтверждение значимости организационных резервов роста, апробация методики выявления организационных резервов повышения производительности труда. Методы исследования. В настоящей работе нашли применение методы сбора первичной экономической информации, включая анализ законодательных и нормативно-правовых актов РФ, официальных статистических данных, данных публичной отчетности отечественных предприятий, анализ прочих открытых источников информации, системный подход, методы статистического и сравнительного анализа. The country's labor productivity in modern Russia over recent years has acquired impressive relevance. Since it is a key indicator of overall economic efficiency, strong labor productivity growth has always been a sufficient condition for socio-economic development, economic stability and enhancing competitiveness of the national economy. The relevance of the study is determined by the urgency of the labor productivity growth at the modern Russian factories that can be achieved through realization of organizational reserves. The main aim of the study is identifying and structuring the factors that seem to affect labor productivity level. It is also pointed at corroborating the necessity of labor productivity growth and approbation of organizational reserves seeking method. Methods. In the present work different methods of information gathering and processing were used to obtain the economic data including the analysis of appropriate laws and regulations, official statistics, companies' public statements and reporting and other open available resources. Also system approach, comparative and statistical analysis were adopted in this research
A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants
RING and U-box E3 ubiquitin ligases regulate diverse eukaryotic processes and have been implicated in numerous diseases, but targeting these enzymes remains a major challenge. We report the development of three ubiquitin variants (UbVs), each binding selectively to the RING or U-box domain of a distinct E3 ligase: monomeric UBE4B, phosphorylated active CBL, or dimeric XIAP. Structural and biochemical analyses revealed that UbVs specifically inhibited the activity of UBE4B or phosphorylated CBL by blocking the E2∼Ub binding site. Surprisingly, the UbV selective for dimeric XIAP formed a dimer to stimulate E3 activity by stabilizing the closed E2∼Ub conformation. We further verified the inhibitory and stimulatory functions of UbVs in cells. Our work provides a general strategy to inhibit or activate RING/U-box E3 ligases and provides a resource for the research community to modulate these enzymes
Bending AdS Waves with New Massive Gravity
We study AdS-waves in the three-dimensional new theory of massive gravity
recently proposed by Bergshoeff, Hohm, and Townsend. The general configuration
of this type is derived and shown to exhibit different branches, with different
asymptotic behaviors. In particular, for the special fine tuning
, solutions with logarithmic fall-off arise, while in the
range , spacetimes with Schrodinger isometry group are admitted
as solutions. Solutions that are asymptotically AdS, both for
Brown-Henneaux and for the weakened boundary conditions, are also identified.
The metric function that characterizes the profile of the AdS-wave behaves as a
massive excitation on the spacetime, with an effective mass given by
. For the critical value , the value of
the effective mass precisely saturates the Breitenlohner-Freedman bound for the
AdS space where the wave is propagating on. The analogies with the AdS-wave
solutions of topologically massive gravity are also discussed. Besides, we
consider the coupling of both massive deformations to Einstein gravity and find
the exact configurations for the complete theory, discussing all the different
branches exhaustively. One of the effects of introducing the Chern-Simons
gravitational term is that of breaking the degeneracy in the effective mass of
the generic modes of pure New Massive Gravity, producing a fine structure due
to parity violation. Another effect is that the zoo of exact logarithmic
specimens becomes considerably enlarged.Comment: 9 pages. Minor typos correcte
Three-dimensional black holes, gravitational solitons, kinks and wormholes for BHT massive gravity
The theory of massive gravity in three dimensions recently proposed by
Bergshoeff, Hohm and Townsend (BHT) is considered. At the special case when the
theory admits a unique maximally symmetric solution, a conformally flat space
that contains black holes and gravitational solitons for any value of the
cosmological constant is found. For negative cosmological constant, the black
hole is characterized in terms of the mass and the "gravitational hair"
parameter, providing a lower bound for the mass. For negative mass parameter,
the black hole acquires an inner horizon, and the entropy vanishes at the
extremal case. Gravitational solitons and kinks, being regular everywhere, are
obtained from a double Wick rotation of the black hole. A wormhole solution in
vacuum that interpolates between two static universes of negative spatial
curvature is obtained as a limiting case of the gravitational soliton with a
suitable identification. The black hole and the gravitational soliton fit
within a set of relaxed asymptotically AdS conditions as compared with the ones
of Brown and Henneaux. In the case of positive cosmological constant the black
hole possesses an event and a cosmological horizon, whose mass is bounded from
above. Remarkably, the temperatures of the event and the cosmological horizons
coincide, and at the extremal case one obtains the analogue of the Nariai
solution, . A gravitational soliton is also obtained
through a double Wick rotation of the black hole. The Euclidean continuation of
these solutions describes instantons with vanishing Euclidean action. For
vanishing cosmological constant the black hole and the gravitational soliton
are asymptotically locally flat spacetimes. The rotating solutions can be
obtained by boosting the previous ones in the plane.Comment: Talk given at the "Workshop on Gravity in Three Dimensions," 14-24
April 2009, ESI, Vienna. 30 pages, 6 figures. V2: minor changes and section 6
slightly improved. Last version for JHE
Extra gauge symmetries in BHT gravity
We study the canonical structure of the Bergshoeff-Hohm-Townsend massive
gravity, linearized around a maximally symmetric background. At the critical
point in the space of parameters, defined by , we discover an
extra gauge symmetry, which reflects the existence of the partially massless
mode. The number of the Lagrangian degrees of freedom is found to be 1. We show
that the canonical structure of the theory at the critical point is unstable
under linearization.Comment: LATEX, 12 page
Discussing Quantum Aspects of Higher-Derivative 3D-Gravity in the First-Order Formalism
In this paper, we reassess the issue of deriving the propagators and
identifying the spectrum of excitations associated to the vielbein and spin
connection of (1+2)-D gravity in the presence of dynamical torsion, while
working in the first-order formulation. A number of peculiarities is pointed
out whenever the Chern-Simons term is taken into account along with a
combination of bilinear terms in the torsion tensor. We present a procedure to
derive the full set of propagators, based on an algebra of enlarged spin-type
operators, and we discuss under which conditions the poles of the tree-level
2-point functions correspond to physical excitations that do not conflict with
causality and unitarity
Risk perception, safer sex practices and PrEP enthusiasm: Barriers and facilitators to oral HIV pre-exposure prophylaxis in Black African and Black Caribbean women in the UK
Objectives: UK Black African/Black Caribbean women remain disproportionately affected by HIV. Although oral pre-exposure prophylaxis (PrEP) could offer them an effective HIV prevention method, uptake remains limited. This study examined barriers and facilitators to PrEP awareness and candidacy perceptions for Black African/Black Caribbean women to help inform PrEP programmes and service development. Methods: Using purposive sampling through community organisations, 32 in-depth, semi-structured interviews were conducted with Black African/Black Caribbean women living in London and Glasgow between June and August 2018. Participants (aged 19–63) included women of varied HIV statuses to explore perceptions of sexual risk and safer sex, sexual health knowledge and PrEP attitudes. A thematic analysis guided by the Social Ecological Model was used to explore how PrEP perceptions intersected with wider safer sex understandings and practices. Results: Four key levels of influence shaping safer sex notions and PrEP candidacy perceptions emerged: personal, interpersonal, perceived environment and policy. PrEP-specific knowledge was low and some expressed distrust in PrEP. Many women were enthusiastic about PrEP for others but did not situate PrEP within their own safer sex understandings, sometimes due to difficulty assessing their own HIV risk. Many felt that PrEP could undermine intimacy in their relationships by disrupting the shared responsibility implicit within other HIV prevention methods. Women described extensive interpersonal networks that supported their sexual health knowledge and shaped their interactions with health services, though these networks were influenced by prevailing community stigmas. Conclusions: Difficulty situating PrEP within existing safer sex beliefs contributes to limited perceptions of personal PrEP candidacy. To increase PrEP uptake in UK Black African/Black Caribbean women, interventions will need to enable women to advance their knowledge of PrEP within the broader context of their sexual health and relationships. PrEP service models will need to include trusted ‘non-sexual health-specific’ community services such as general practice
Harnessing the immune system in the battle against breast cancer
Breast cancer is the most prevalent malignancy in women and the second most common cause of cancer-related death worldwide. Despite major innovations in early detection and advanced therapeutics, up to 30% of women with nodenegative breast cancer and 70% of women with node-positive breast cancer will develop recurrence. The recognition that breast tumors are infiltrated by a complex array of immune cells that influence their development, progression, and metastasis, as well as their responsiveness to systemic therapies has sparked major interest in the development of immunotherapies. In fact, not only the native host immune system can be altered to promote potent antitumor response, but also its components can be manipulated to generate effective therapeutic strategies. We present here a review of the major approaches to immunotherapy in breast cancers, both successes and failures, as well as new therapies on the horizon
Massive Gravity Theories and limits of Ghost-free Bigravity models
We construct a class of theories which extend New Massive Gravity to higher
orders in curvature in any dimension. The lagrangians arise as limits of a new
class of bimetric theories of Lovelock gravity, which are unitary theories free
from the Boulware-Deser ghost. These Lovelock bigravity models represent the
most general non-chiral ghost-free theories of an interacting massless and
massive spin-two field in any dimension. The scaling limit is taken in such a
way that unitarity is explicitly broken, but the Boulware-Deser ghost remains
absent. This automatically implies the existence of a holographic -theorem
for these theories. We also show that the Born-Infeld extension of New Massive
Gravity falls into our class of models demonstrating that this theory is also
free of the Boulware-Deser ghost. These results extend existing connections
between New Massive Gravity, bigravity theories, Galileon theories and
holographic -theorems.Comment: 11+5 page
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