628 research outputs found
Dynamical Generation of CKM Mixings by Broken Horizontal Gauge Interactions
The fermion mass matrices are calculated in the framework of the dynamical
mass generation by the broken horizontal gauge interactions. The
non-proportional mass spectra between up- and down-sectors and CKM mixings are
obtained solely by radiative corrections due to the ordinary gauge
interactions.Comment: 20 pages + 1 uuencoded eps figure, PHYZZ
Collective synchronization in populations of globally coupled phase oscillators with drifting frequencies
We generalize the Kuramoto model for coupled phase oscillators by allowing
the frequencies to drift in time according to Ornstein-Uhlenbeck dynamics. Such
drifting frequencies were recently measured in cellular populations of
circadian oscillator and inspired our work. Linear stability analysis of the
Fokker-Planck equation for an infinite population is amenable to exact solution
and we show that the incoherent state is unstable passed a critical coupling
strength K_c(\ga, \sigf), where \ga is the inverse characteristic drifting
time and \sigf the asymptotic frequency dispersion. Expectedly agrees
with the noisy Kuramoto model in the large \ga (Schmolukowski) limit but
increases slower as \ga decreases. Asymptotic expansion of the solution for
\ga\to 0 shows that the noiseless Kuramoto model with Gaussian frequency
distribution is recovered in that limit. Thus varying a single parameter allows
to interpolate smoothly between two regimes: one dominated by the frequency
dispersion and the other by phase diffusion.Comment: 5 pages, 5 figures, accepted in Phys. Rev.
USP2-45 Is a Circadian Clock Output Effector Regulating Calcium Absorption at the Post-Translational Level.
The mammalian circadian clock influences most aspects of physiology and behavior through the transcriptional control of a wide variety of genes, mostly in a tissue-specific manner. About 20 clock-controlled genes (CCGs) oscillate in virtually all mammalian tissues and are generally considered as core clock components. One of them is Ubiquitin-Specific Protease 2 (Usp2), whose status remains controversial, as it may be a cogwheel regulating the stability or activity of core cogwheels or an output effector. We report here that Usp2 is a clock output effector related to bodily Ca2+ homeostasis, a feature that is conserved across evolution. Drosophila with a whole-body knockdown of the orthologue of Usp2, CG14619 (dUsp2-kd), predominantly die during pupation but are rescued by dietary Ca2+ supplementation. Usp2-KO mice show hyperabsorption of dietary Ca2+ in small intestine, likely due to strong overexpression of the membrane scaffold protein NHERF4, a regulator of the Ca2+ channel TRPV6 mediating dietary Ca2+ uptake. In this tissue, USP2-45 is found in membrane fractions and negatively regulates NHERF4 protein abundance in a rhythmic manner at the protein level. In clock mutant animals (Cry1/Cry2-dKO), rhythmic USP2-45 expression is lost, as well as the one of NHERF4, confirming the inverse relationship between USP2-45 and NHERF4 protein levels. Finally, USP2-45 interacts in vitro with NHERF4 and endogenous Clathrin Heavy Chain. Taken together these data prompt us to define USP2-45 as the first clock output effector acting at the post-translational level at cell membranes and possibly regulating membrane permeability of Ca2+
A Complete Perturbative Expansion for Constrained Quantum Dynamics
A complete perturbative expansion for the Hamiltonian describing the motion
of a quantomechanical system constrained to move on an arbitrary submanifold of
its configuration space is obtained.Comment: 18 pages, LaTe
Measurement of the Xi-p Scattering Cross Sections at Low Energy
In this paper we report cross-section measurements for elastic and
inelastic scatterings at low energy using a scintillating fiber active target.
Upper limit on the total cross-section for the elastic scattering was found to
be 24 mb at 90% confidence level, and the total cross section for the
reaction was found to be mb. We
compare the results with currently competing theoretical estimates.Comment: 9 page
The splicing regulators Tra and Tra2 are unusually potent activators of pre-mRNA splicing
Sexual differentiation in Drosophila is regulated through alternative splicing of doublesex. Female-specific splicing is activated through the activity of splicing enhancer complexes assembled on multiple repeat elements. Each of these repeats serves as a binding platform for the cooperative assembly of a heterotrimeric complex consisting of the SR proteins Tra, Tra2 and 9G8. Using quantitative kinetic analyses, we demonstrate that each component of the enhancer complex is capable of recruiting the spliceosome. Surprisingly, Tra, Tra2 and 9G8 are much stronger splicing activators than other SR protein family members and their activation potential is significantly higher than expected from their serine/arginine content. 9G8 activates splicing not only through its RS domains but also through its RNA-binding domain. The RS domains of Tra and Tra2 are required but not sufficient for efficient complex assembly. Thus, the regulated assembly of the dsx enhancer complexes leads to the generation of an extended activation domain to guarantee the ‘all or none’ splicing switch that is required during Drosophila sexual differentiation
Doping Dependence of the Electronic Structure of Ba_{1-x}K_{x}BiO_{3} Studied by X-Ray Absorption Spectroscopy
We have performed x-ray absorption spectroscopy (XAS) and x-ray photoemission
spectroscopy (XPS) studies of single crystal Ba_{1-x}K_{x}BiO_{3} (BKBO)
covering the whole composition range . Several features in
the oxygen 1\textit{s} core XAS spectra show systematic changes with .
Spectral weight around the absorption threshold increases with hole doping and
shows a finite jump between and 0.40, which signals the
metal-insulator transition. We have compared the obtained results with
band-structure calculations. Comparison with the XAS results of
BaPb_{1-x}Bi_{x}O_{3} has revealed quite different doping dependences between
BKBO and BPBO. We have also observed systematic core-level shifts in the XPS
spectra as well as in the XAS threshold as functions of , which can be
attributed to a chemical potential shift accompanying the hole doping. The
observed chemical potential shift is found to be slower than that predicted by
the rigid band model based on the band-structure calculations.Comment: 8 pages, 8 figures include
Enteric Neurospheres Are Not Specific to Neural Crest Cultures: Implications for Neural Stem Cell Therapies
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited
Schwann-Spheres Derived from Injured Peripheral Nerves in Adult Mice - Their In Vitro Characterization and Therapeutic Potential
Multipotent somatic stem cells have been identified in various adult tissues. However, the stem/progenitor cells of the peripheral nerves have been isolated only from fetal tissues. Here, we isolated Schwann-cell precursors/immature Schwann cells from the injured peripheral nerves of adult mice using a floating culture technique that we call “Schwann-spheres." The Schwann-spheres were derived from de-differentiated mature Schwann cells harvested 24 hours to 6 weeks after peripheral nerve injury. They had extensive self-renewal and differentiation capabilities. They strongly expressed the immature-Schwann-cell marker p75, and differentiated only into the Schwann-cell lineage. The spheres showed enhanced myelin formation and neurite growth compared to mature Schwann cells in vitro. Mature Schwann cells have been considered a promising candidate for cell-transplantation therapies to repair the damaged nervous system, whereas these “Schwann-spheres" would provide a more potential autologous cell source for such transplantation
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