ARCADE 2 Measurement of the Extra-Galactic Sky Temperature at 3-90 GHz

The ARCADE 2 instrument has measured the absolute temperature of the sky at frequencies 3, 8, 10, 30, and 90 GHz, using an open-aperture cryogenic instrument observing at balloon altitudes with no emissive windows between the beam-forming optics and the sky. An external blackbody calibrator provides an {\it in situ} reference. Systematic errors were greatly reduced by using differential radiometers and cooling all critical components to physical temperatures approximating the CMB temperature. A linear model is used to compare the output of each radiometer to a set of thermometers on the instrument. Small corrections are made for the residual emission from the flight train, balloon, atmosphere, and foreground Galactic emission. The ARCADE 2 data alone show an extragalactic rise of $50\pm7$ mK at 3.3 GHz in addition to a CMB temperature of $2.730\pm .004$ K. Combining the ARCADE 2 data with data from the literature shows a background power law spectrum of $T=1.26\pm 0.09$ [K] $(\nu/\nu_0)^{-2.60\pm 0.04}$ from 22 MHz to 10 GHz ($\nu_0=1$ GHz) in addition to a CMB temperature of $2.725\pm .001$ K.Comment: 11 pages 5 figures Submitted to Ap

The Temperature of the CMB at 10 GHz

We report the results of an effort to measure the low frequency portion of the spectrum of the Cosmic Microwave Background Radiation (CMB), using a balloon-borne instrument called ARCADE (Absolute Radiometer for Cosmology, Astrophysics, and Diffuse Emission). These measurements are to search for deviations from a thermal spectrum that are expected to exist in the CMB due to various processes in the early universe. The radiometric temperature was measured at 10 and 30 GHz using a cryogenic open-aperture instrument with no emissive windows. An external blackbody calibrator provides an in situ reference. A linear model is used to compare the radiometer output to a set of thermometers on the instrument. The unmodeled residuals are less than 50 mK peak-to-peak with a weighted RMS of 6 mK. Small corrections are made for the residual emission from the flight train, atmosphere, and foreground Galactic emission. The measured radiometric temperature of the CMB is 2.721 +/- 0.010 K at 10 GHz and 2.694 +/- 0.032 K at 30 GHz.Comment: 8 pages including 5 figures. Submitted to The Astrophysical Journa

ARCADE: Absolute Radiometer for Cosmology, Astrophysics, and Diffuse Emission

The Absolute Radiometer for Cosmology, Astrophysics, and Diffuse Emission (ARCADE) is a balloon-borne instrument designed to measure the temperature of the cosmic microwave background at centimeter wavelengths. ARCADE searches for deviations from a blackbody spectrum resulting from energy releases in the early universe. Long-wavelength distortions in the CMB spectrum are expected in all viable cosmological models. Detecting these distortions or showing that they do not exist is an important step for understanding the early universe. We describe the ARCADE instrument design, current status, and future plans.Comment: 12 pages, 6 figures. Proceedings of the Fundamental Physics With CMB workshop, UC Irvine, March 23-25, 2006, to be published in New Astronomy Review

Development of multiplex real-time PCR assays for identification of members of the Anopheles funestus species group

BACKGROUND: The malaria vector and non-vector species of the Anopheles funestus group are morphologically very similar and accurate identification is required as part of effective control strategies. In the past, this has relied on morphological and cytogenetic methods but these have been largely superseded by a robust allele-specific PCR (AS-PCR). One disadvantage of AS-PCR is the requirement for post-PCR processing by gel electrophoresis of PCR products. In this study, three new high-throughput 'closed-tube' assays were developed and compared with the previously described AS-PCR technique. METHODS: Protocols for three fluorescence-based assays based on Melt Curve Analysis (MCA), High Resolution Melt (HRM) and TaqMan SNP genotyping were developed to detect and discriminate Anopheles parensis, Anopheles leesoni, Anopheles vaneedeni, Anopheles rivulorum and An. funestus s.s. The sensitivity and specificity of these assays were compared with the widely used AS-PCR in a blind trial using DNA extracted from wild-caught mosquitoes. RESULTS: The TaqMan assay proved to be the most sensitive and specific of the three new assays. The MCA and HRM assays initially gave promising results, but were more sensitive to both DNA quality and quantity and consequently showed a higher rate of incorrect identifications. CONCLUSION: The TaqMan assay proved to be the most robust of the three protocols tested in this study. This assay very effectively identified all five members of the An. funestus group using fluorescently-labeled probes with distinct emission and excitation spectra allowing their independent detection in a single reaction. This method is at least as sensitive and specific as the gold standard AS-PCR approach and because it has no requirement for post-PCR processing is simpler and more rapid to run. The one disadvantage of the TaqMan assay is the cost of this assay, both in terms of initial capital outlay and running cost per sample, which is higher than AS-PCR. However, the cost of both the real-time PCR machine and fluorescently labelled probes required is falling and in the future the cost of this assay is likely to become closer to that of standard PCR

Cancer Informatics for Cancer Centers (CI4CC): Building a Community Focused on Sharing Ideas and Best Practices to Improve Cancer Care and Patient Outcomes.

Cancer Informatics for Cancer Centers (CI4CC) is a grassroots, nonprofit 501c3 organization intended to provide a focused national forum for engagement of senior cancer informatics leaders, primarily aimed at academic cancer centers anywhere in the world but with a special emphasis on the 70 National Cancer Institute-funded cancer centers. Although each of the participating cancer centers is structured differently, and leaders' titles vary, we know firsthand there are similarities in both the issues we face and the solutions we achieve. As a consortium, we have initiated a dedicated listserv, an open-initiatives program, and targeted biannual face-to-face meetings. These meetings are a place to review our priorities and initiatives, providing a forum for discussion of the strategic and pragmatic issues we, as informatics leaders, individually face at our respective institutions and cancer centers. Here we provide a brief history of the CI4CC organization and meeting highlights from the latest CI4CC meeting that took place in Napa, California from October 14-16, 2019. The focus of this meeting was "intersections between informatics, data science, and population science." We conclude with a discussion on "hot topics" on the horizon for cancer informatics

ARCADE 2 Observations of Galactic Radio Emission

We use absolutely calibrated data from the ARCADE 2 flight in July 2006 to model Galactic emission at frequencies 3, 8, and 10 GHz. The spatial structure in the data is consistent with a superposition of free-free and synchrotron emission. Emission with spatial morphology traced by the Haslam 408 MHz survey has spectral index beta_synch = -2.5 +/- 0.1, with free-free emission contributing 0.10 +/- 0.01 of the total Galactic plane emission in the lowest ARCADE 2 band at 3.15 GHz. We estimate the total Galactic emission toward the polar caps using either a simple plane-parallel model with csc|b| dependence or a model of high-latitude radio emission traced by the COBE/FIRAS map of CII emission. Both methods are consistent with a single power-law over the frequency range 22 MHz to 10 GHz, with total Galactic emission towards the north polar cap T_Gal = 0.498 +/- 0.028 K and spectral index beta = -2.55 +/- 0.03 at reference frequency 1 GHz. The well calibrated ARCADE 2 maps provide a new test for spinning dust emission, based on the integrated intensity of emission from the Galactic plane instead of cross-correlations with the thermal dust spatial morphology. The Galactic plane intensity measured by ARCADE 2 is fainter than predicted by models without spinning dust, and is consistent with spinning dust contributing 0.4 +/- 0.1 of the Galactic plane emission at 22 GHz.Comment: 10 poges, 9 figures. Submitted to The Astrophysical Journa

ARCADE 2 Observations of Galactic Radio Emission

We use absolutely calibrated data from the ARCADE 2 flight in 2006 July to model Galactic emission at frequencies 3, 8, and 10 GHz. The spatial structure in the data is consistent with a superposition of free–free and synchrotron emission. Emission with spatial morphology traced by the Haslam 408 MHz survey has spectral index βsynch = −2.5±0.1, with free–free emission contributing 0.10±0.01 of the total Galactic plane emission in the lowest ARCADE 2 band at 3.15 GHz. We estimate the total Galactic emission toward the polar caps using either a simple plane-parallel model with csc |b| dependence or a model of high-latitude radio emission traced by the COBE/FIRAS map of C ii emission. Both methods are consistent with a single power law over the frequency range 22 MHz to 10 GHz, with total Galactic emission toward the north polar cap TGal = 10.12 ± 0.90 K and spectral index β = −2.55 ± 0.03 at reference frequency 0.31 GHz. Emission associated with the plane-parallel structure accounts for only 30% of the observed high-latitude sky temperature, with the residual in either a Galactic halo or an isotropic extragalactic background. The well-calibrated ARCADE 2 maps provide a new test for spinning dust emission, based on the integrated intensity of emission from the Galactic plane instead of cross-correlations with the thermal dust spatial morphology. The Galactic plane intensity measured by ARCADE 2 is fainter than predicted by models without spinning dust and is consistent with spinning dust contributing 0.4 ± 0.1 of the Galactic plane emission at 23 GHz