608 research outputs found
COTGAME: Cotton Insect Pest Management Simulation Game
An interactive version of the Cotton and Insect Management (CIM) model was developed to aid individuals in improving their insect pest management decision making skills. This version, COTGAME, allowed the user to encounter situations and make decisions during the simulated cotton crop growing season. The intermediate results of these decisions were immediately delivered in the form of a report on the current status of the crop and insect populations. Based on the information presented in this status report, the user would make additional management decisions and take tactical actions. Once the harvest date had been reached, the economics of the simulated production season was presented to allow the user to evaluate the decisions. The use of COTGAME has been a way to apply the technology in a detailed crop growth model to improving insect pest management skills
RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer
Triple negative breast cancer (TNBC) is characterized by multiple genetic events occurring in concert to drive pathogenic features of the disease. Here we interrogated the coordinate impact of p53, RB, and MYC in a genetic model of TNBC, in parallel with the analysis of clinical specimens. Primary mouse mammary epithelial cells (mMEC) with defined genetic features were used to delineate the combined action of RB and/or p53 in the genesis of TNBC. In this context, the deletion of either RB or p53 alone and in combination increased the proliferation of mMEC; however, the cells did not have the capacity to invade in matrigel. Gene expression profiling revealed that loss of each tumor suppressor has effects related to proliferation, but RB loss in particular leads to alterations in gene expression associated with the epithelial-to-mesenchymal transition. The overexpression of MYC in combination with p53 loss or combined RB/p53 loss drove rapid cell growth. While the effects of MYC overexpression had a dominant impact on gene expression, loss of RB further enhanced the deregulation of a gene expression signature associated with invasion. Specific RB loss lead to enhanced invasion in boyden chambers assays and gave rise to tumors with minimal epithelial characteristics relative to RB-proficient models. Therapeutic screening revealed that RB-deficient cells were particularly resistant to agents targeting PI3K and MEK pathway. Consistent with the aggressive behavior of the preclinical models of MYC overexpression and RB loss, human TNBC tumors that express high levels of MYC and are devoid of RB have a particularly poor outcome. Together these results underscore the potency of tumor suppressor pathways in specifying the biology of breast cancer. Further, they demonstrate that MYC overexpression in concert with RB can promote a particularly aggressive form of TNB
Inferring the Origin Locations of Tweets with Quantitative Confidence
Social Internet content plays an increasingly critical role in many domains,
including public health, disaster management, and politics. However, its
utility is limited by missing geographic information; for example, fewer than
1.6% of Twitter messages (tweets) contain a geotag. We propose a scalable,
content-based approach to estimate the location of tweets using a novel yet
simple variant of gaussian mixture models. Further, because real-world
applications depend on quantified uncertainty for such estimates, we propose
novel metrics of accuracy, precision, and calibration, and we evaluate our
approach accordingly. Experiments on 13 million global, comprehensively
multi-lingual tweets show that our approach yields reliable, well-calibrated
results competitive with previous computationally intensive methods. We also
show that a relatively small number of training data are required for good
estimates (roughly 30,000 tweets) and models are quite time-invariant
(effective on tweets many weeks newer than the training set). Finally, we show
that toponyms and languages with small geographic footprint provide the most
useful location signals.Comment: 14 pages, 6 figures. Version 2: Move mathematics to appendix, 2 new
references, various other presentation improvements. Version 3: Various
presentation improvements, accepted at ACM CSCW 201
Financial Capability and Asset Building in Social Work Education: “The Big Piece Missing?”
Since the 1990s, social workers have renewed the profession’s early focus on improving the financial well-being of vulnerable families. Nonetheless, most social workers receive little training and education about how to help clients build stable and secure financial lives. This study uses in-depth interviews and pre- and post-surveys to examine the effects of a Financial Capability and Asset Building (FCAB) curriculum in six Minority Serving Institutions. In-depth interviews with 24 school administrators, FCAB instructors, and faculty colleagues suggest that faculty chose FCAB content based on course goals, content utility, and alignment with social work education standards. Furthermore, faculty reported gaining confidence and students reported gaining an understanding of and appreciation for FCAB, especially as a result of practical application of FCAB concepts. Pre- and post-surveys with 147 students indicate increased confidence in helping clients with basic financial management, understanding the importance of developing appropriate financial services, and changing personal financial behaviors, such as checking one’s credit report. Despite initial positive results, the curriculum requires more extensive and rigorous testing to inform growing efforts in the profession to improve financial well-being in low-income and financially vulnerable households. This article was subsequently published in the Journal of Social Work Education’s Special Section on Financial Capability and Asset Building. an earlier version of this article was presented during the April 2015 conference, Financial Capability and Asset Building: Advancing Education, Research, and Practice in Social Work. The conference was hosted by the Center for Social Development and the Financial Social Work Initiative at the University of Maryland School of Social Work
Financial Capability and Asset Building: Achievements, Challenges, and Next Steps
In the midst of a global pandemic that brought untold numbers of families to a financial precipice, experts came together to examine the role of social work in ensuring financial security and equity for all. This conference report details the most recent of five Financial Capability and Asset Building (FCAB) conferences held since 2015. The two-part virtual conference, held in September 2020 and February 2021, convened leaders in the academy and in the field to discuss achievements, challenges, and next steps in FCAB
Effects of an Informal Place-based Educational Program on Knowledge and Perceptions of Invasive Species Management
Invasive species can generate negative impacts environmentally, socially, and economically. The interplay between human and natural systems renders management a complex problem that must be addressed by decision-makers. Perceptions of invasive species issues varies depending on an individual’s access to information. Although invasive species and their management are often discussed in formal higher education, not all members of the population have access to a formal educational setting. Informal educational experiences may be a mechanism to reach out to community members in a more accessible and perhaps engaging way than traditional higher education classroom experiences. The purpose of this study was to determine the effect of an informal, place-based educational program on perceptions and knowledge of invasive species and their management within the community. Place-based education is a pedagogy connection local places with intimate knowledge of the systems, processes, and outcomes that give it meaning to human and non-human species. First, we organized and administered short walks in two central Texas, USA, parks with conversational lessons and hands-on learning experiences. Second, we administered a follow-up retrospective-reflective survey to measure participants’ knowledge and perceptions of invasive species management and postwalk/lesson changes in them. We also compared between the treatment group of participants versus a control group within the community who did not participate in the informal lessons. Fifty-two people participated in both the educational program walks and testing over the course of 1 year, and 63 people were included in the follow-up retrospective-reflective survey control group. Results indicate a statistically significant positive change in knowledge and perception categories within the treatment group. Post hoc results indicate a positive change in knowledge and perceptions in our sample as a function of treatment group members’ age and income, respectively. The methodology used in this study was simple and inexpensive. Hence, our approach could be easily replicated in other areas to educate community members
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Evaluating the Performance and Economics of Transpired Solar Collectors for Commercial Applications: Preprint
Using transpired solar collectors to preheat ventilation air has recently become recognized as an economic alternative for integrating renewable energy into commercial buildings in heating climates. The collectors have relatively low installed costs and operate on simple principles. Theory and performance testing have shown that solar collection efficiency can exceed 70% of incident solar. However, implementation and current absorber designs have adversely affected the efficiency and associated economics from this initial analysis. The National Renewable Energy Laboratory has actively studied this technology and monitored performance at several installations. A calibrated model that uses typical meteorological weather data to determine absorber plate efficiency resulted from this work. With this model, an economic analysis across heating climates was done to show the effects of collector size, tilt, azimuth, and absorptivity. The analysis relates the internal rate of return of a system based on the cost of the installed absorber area. In general, colder and higher latitude climates return a higher rate of return because the heating season extends into months with good solar resource
Career success: the role of teenage career aspirations, ambition value and gender in predicting adult social status and earnings
Links between family social background, teenage career aspirations, educational performance and adult social status attainment are well documented. Using a contextual developmental framework, this article extends previous research by examining the role of gender and teenage ambition value in shaping social status attainment and earnings in adulthood. Drawing on data from an 18-year British follow up study we tested a path model linking family background factors (such as family social status and parental aspirations) and individual agency factors in adolescence (in particular, career aspirations and ambition value) to social status attainment and earnings in adulthood. The findings suggest that ambition value is linked to adult earnings. That is, young people for whom it is important to get on in their job earn more money in adulthood than their less ambitious peers. The findings also confirm that teenage career aspirations are linked to adult social status attainment, and suggest that family background factors, teenage career aspirations and ambition value interact to influence social status attainment and earnings in adulthood. Gender differences are discusse
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