Formulation and Stability Study of Eslicarbazepine Acetate Oral Suspensions for Extemporaneous Compounding

Eslicarbazepine acetate is an anticonvulsant drug with a recent U.S. Food and Drug Administration approval for expanded use in children and adolescents. Currently, eslicarbazepine acetate is only available in the U.S. as 200-mg to 800-mg strength tablets (Aptiom), which are not easy to administer for pediatric patients. This study was initiated to develop an oral suspension formulation for extemporaneous compounding by pharmacists and to generate stability data for storage recommendations. Nine suspension formulations of eslicarbazepine acetate were prepared from Aptiom tablets and commercially available liquid vehicles using the standard mortar/pestle method. The vehicles varied mainly in their solvents, viscosities, and sweeteners. The formulations were evaluated for ease of preparation, physical properties, and initial potency. Two lead formulations were selected for a two-month stability study at room temperature or under refrigeration (2°C to 8°C). The stability samples were withdrawn at pre-determined time points and analyzed by visual inspection, pH measurement, and a stability-indicating high-performance liquid chromatographic assay. The majority of the 9 formulations were found to be easy to prepare and administer at a concentration of 40-mg/mL eslicarbazepine acetate. Particle settling was observed in several formulations over time, but they were re-suspended satisfactorily upon shaking. Two suspensions in 50:50 v/v mixtures of Ora-Sweet or Ora-Sweet SF with Ora-Plus were selected as the lead formulations for the two-month stability study. At the initiation of the study, all samples appeared as white and smooth suspensions with pH ranging from 4.39 to 4.46. The high-performance liquid chromatographic results confirmed that the initial samples contained 100.4% to 102.2% of the label claim strength. Over two months of storage at room temperature or refrigeration, there were no significant changes in visual appearance, re-suspendability, pH, or potency for any samples. No new degradation peaks were observed in any highperformance liquid chromatograms. Based on the study results, two eslicarbazepine acetate suspensions are recommended for extemporaneous compounding from Aptiom tablets. The formulations consist of 40 mg/mL eslicarbazepine acetate in 50:50 v/v Ora-Sweet:Ora-Plus or Ora-Sweet SF:Ora-Plus. Once prepared, these suspensions can be stored at room temperature or under refrigeration for up to two months

Warming up brane-antibrane inflation

We show that, in constructions with additional intersecting D-branes, brane-antibrane inflation may naturally occur in a warm regime, such that strong dissipative effects damp the inflaton's motion, greatly alleviating the associated eta-problem. We illustrate this for D3-antiD3 inflation in flat space with additional flavor D7-branes, where for both a Coulomb-like or a quadratic hybrid potential a sufficient number of e-folds may be obtained for perturbative couplings and O(10-10^4) branes. This is in clear contrast with the corresponding cold scenarios, thus setting the stage for more realistic constructions within fully stabilized compactifications. Such models generically predict a negligible amount of tensor perturbations and non-gaussianity f_NL \sim O(10).Comment: 8 pages, 2 figures; version to be published in Physical Review

Exercise for acute respiratory infections

No abstract available

Acompa?amientos sensibles

45 p. Recurso Electr?nicoAcompa?amientos sensibles es una exploraci?n que se propone encontrar maneras de cuidar desde el arte pl?stico y visual en el hospital Federico Lleras Acosta en la ciudad de Ibagu?, Tolima y posteriormente en el hospital San Vicente de Paul en Fresno, Tolima. Est? dedicado a pensar c?mo se generan gestos y maneras de acompa?ar en el intento de entender y abrazar a los habitantes del territorio hospitalario brind?ndoles escucha y atenci?n para as? humanizar dicho territorio. Palabras clave: Gesto, habitar, clown hospitalario, acci?n.Sensitive accompaniment is a exploration that aims to find ways of caring from plastic an visual art in the Federico Lleras Acosta hospital in the city of Ibague, Tolima and later in the San Vicente de Paul hospital in Fresno, Tolima. It is dedicated to think about how gestures and ways to come along are generated in the attempt to understand and embrace the inhabitants of the hospital territory, providing them with someone to listen and bring them attention in order to humanize the same territory. Keywords: gesture, inhabit, hospital clown, action

Research on ICT in K-12 schools e A review of experimental and survey-based studies in computers & education 2011 to 2015

International audienceWhat is the role of a journal? Is it to follow the research or lead it? For the former, it is to serve as an archival record of the scholarship in a field. It can serve to permit the research community to engage with each other via the written record. But, for the latter, it can serve the research community by pointing out gaps in the research based on the archival record. This review is intended to do just that

Voltage-controlled electron tunnelling from a single self-assembled quantum dot embedded in a two-dimensional-electron-gas-based photovoltaic cell

We perform high-resolution photocurrent (PC) spectroscopy to investigate resonantly the neutral exciton ground-state (X0) in a single InAs/GaAs self-assembled quantum dot (QD) embedded in the intrinsic region of an n-i-Schottky photodiode based on a two-dimensional electron gas (2DEG), which was formed from a Si delta-doped GaAs layer. Using such a device, a single-QD PC spectrum of X0 is measured by sweeping the bias-dependent X0 transition energy through that of a fixed narrow-bandwidth laser via the quantum-confined Stark effect (QCSE). By repeating such a measurement for a series of laser energies, a precise relationship between the X0 transition energy and bias voltage is then obtained. Taking into account power broadening of the X0 absorption peak, this allows for high-resolution measurements of the X0 homogeneous linewidth and, hence, the electron tunnelling rate. The electron tunnelling rate is measured as a function of the vertical electric field and described accurately by a theoretical model, yielding information about the electron confinement energy and QD height. We demonstrate that our devices can operate as 2DEG-based QD photovoltaic cells and conclude by proposing two optical spintronic devices that are now feasible.Comment: 34 pages, 11 figure