The Course of Neurodermatosis in Patients with COVID19

The covid-19 pandemic is associated with dermatological care.A study of a number of cases around the world has revealed a number of potential dermatological manifestations of COVID-19.It is difficult to determine the frequency (from 0.2 to 20.4%) and the time of the appearance of skin manifestations of COVID-19.In addition, the connection of some skin manifestations with the severity of the disease remains unclear.In addition, it cannot be excluded that the observed skin manifestation is a reaction to many COVID-19 treatment methods

Ecological analysis of the fish cestode fauna of the mouth of Kura River

The research was conducted in 2014–2019 in the mouth of Kura River. A total of 334 fish specimens of 24 species were examined by the method of full parasitological dissection. As a result, 17 tapeworm species in two orders and eight families were found: Caryophyllaeus fimbriceps, C. laticeps, Caryophyllaeides fennica, Eubothrium acipenserinum, Bothriocephalus acheilognathi, Ligula colymbi, L. intestinalis, Bothriocephalus acheilognathi, Ligula colymbi, L. intestinalis, Proteocephalus filicollis, P. gobiorum, P. ocellata, P. osculatus, Siluritaenia siluri, Gryporhynchus pusillus, and Paradilepis scolecina. Of these, seven species are specific cyprinid parasites, two species are specific sturgeon parasites, two species are specific to sticklebacks, two species to catfish, and one species to gobies; the other three species parasitize in fishes of various families. The main organ of cestode localisation in the studied fishes is the intestinal lumen, where 11 worm species were found. In other fish organs (body cavity, mucous membrane of the anterior intestine, liver, mesentery, and intestinal walls), the number of tapeworm species ranged from one to four. One cestode species invaded from one to seven fish species. In the bream, we found six tapeworm species, while in the other fish species, from one to five. Among the cestodes found, 14 species infect zooplankton-eating fish and only three species (Caryophyllaeus fimbriceps, C. laticeps, Caryophyllaeides fennica) infect fish that feeds on benthic invertebrates. The largest trophic group was the benthophages; they hosted 12 cestode species. In the planktophages and predators, we found eight and seven tapeworm species, respectively. Predatory fishes like pike, asp, round and bighead gobies accumulate parasites from the bodies of their preys, consequently, their cestode fauna is the richest. Most recorded fishes are euryhaline. Nevertheless, due to the absence of typical marine forms among the found cestodes, we registered more tapeworm species in the fish occurring the highly desalinated area of the Kura mouth than in more mineralized water. Six recorded species (Caryophyllaeus fimbriceps, Bothriocephalus acheilognathi, Ligula colymbi, L. intestinalis, Digramma interrupta, and Paradilepis scolecina) are causative agents of fish diseases. Ligula colymbi and L. intestinalis, which have large plerocercoids, caused pathogenic changes in fish organisms. The other pathogenic species did not induce noticeable disorders. They are much smaller, and, thereto, had comparatively low invasion rate in the examined fish

Genetic diversity of broad beans (Vicia faba) in the collection of the Vavilov Institute and its use in breeding

The paper presents brief information about the history of the collection of broad (horse) beans (Vicia faba L.) at the N.I. Vavilov All-Russian Institute of Plant Genetic Resources (VIR), its composition, research trends, and significance for domestic breeding. The collection started in 1916 with Vavilov’s collecting activities in the Pamirs. Currently, the collection consists of 1733 accessions from 67 countries, obtained from foreign genebanks through germplasm exchange and seed requests, received from domestic and foreign breeders, and collected in numerous expeditions. Broad beans are used for food (vegetable) and feed; they are adapted to a wide range of latitudes and altitudes. A larger part of the collection is represented by fodder accessions. The main principle whereupon the collection is being augmented is the priorities of domestic breeding. The paper provides information on the botanical, environmental and geographical diversity of VIR’s broad bean collection, its level of studiedness, current research issues, and the use of the collection in the breeding process. The crop’s biological traits, characteristics of vegetable and fodder accessions, current breeding trends and source material for breeding are described. A brief analysis of the current status of broad bean breeding in Russia and VIR’s contribution to this process is presented, including the Institute’s direct involvement in the development of several cultivars of both feed and food uses. Presently, 30 broad bean cultivars are listed in the State Register of Breeding Achievements of the Russian Federation, and 28 of them are the products of domestic breeding

Combined Risk Factors and Digestive Disorders in Mid-Lactation Holstein Cows: A Case Study

Digestive disorders can be a significant cause of disease on dairies and are frustrating because of their unpredictability. Diets that may support excellent health in most cases may nonetheless result in significant gastrointestinal disease, even leading to deadly conditions such as hemorrhagic bowel syndrome. To our knowledge, there is limited research on these conditions, as many risk factors fail to reproduce disease when experimentally administered to cows, leading many to conclude that these disorders are generally multifactorial in nature and difficult to replicate. In this case study, we document the outbreak and resolution of digestive disorders among 15 control cows enrolled in a larger production study. Over 14 weeks, cows were individually fed, with milk yield and composition, blood variables, and health observations recorded. The diet included drought-stressed corn silage that introduced difficulties including low energy density, high dry matter content (making it unstable at feedout), and mycotoxin contamination. By weeks 4–5 on the study, sporadic diarrhea began to appear and milk fat content had dropped from 3.7% to 3.4%, on average. Coincident with the onset of environmental heat stress, three cows developed severe digestive disorders, resulting in a displaced abomasum in one cow. At that point, the diet was changed to replace some corn silage with wheat straw, a direct-fed microbial was added to the diet, and organic acid treatment of the silage face was initiated. Within a month after these changes were implemented, essentially all signs of digestive problems resolved, including milk fat content, fecal consistency, and blood plasma concentrations of haptoglobin and D-lactate. This case study points to multiple factors that likely combined to lead to microbial and gastrointestinal disruptions resulting in clinical disease in a subset of cows

Оптимальні геометричні відношення для індукційного левітатора електромеханічних перетворювачів

On the basis of analytical expressions of ampere-hour management windings, of magnetic induction in a steel magnetic conductor and temperatures of winding overheat, the expressions for the geometrical sizes of the levitation screen and management winding are obtained. Examples of optimum geometrical parities are givenНа основе аналитических выражений ампервитков обмотки управления, магнитной индукции в стали магнитопровода и температуры перегрева обмотки получены выражения для геометрических размеров левитационного экрана и обмотки управления. Приведены примеры оптимальных геометрических соотношений.На основі аналітичних виразів ампервитків обмотки керування магнітної індукції у сталі магнітопровода і температури перегріву обмотки отримані вирази для геометричних розмірів левітаційного екрана і обмотки керування. Наведені приклади оптимальних геометричних відношен

Диагностический и терапевтический потенциал трансформирующего фактора роста β1 при трансплантации солидных органов: результаты последних исследований

Federation Clinical outcomes of solid organ transplantation depend on many factors. One of the main factors is the risk of post-transplant complications, which affect allograft and recipient survival. Multifactorial organ damage in post-transplant complications and the search for diagnostic and prognostic indicators of the condition have contributed to the study and selection of a wide range of proteomic and molecular genetic biomarkers, which have shown to be effective in solid organ transplantation. The use of biomarkers opens up additional possibilities for assessing the risk of complications and their early diagnosis. This potentially reduces the frequency of invasive diagnostic procedures. Transforming growth factor beta 1 (TGF-β1) regulates many biological processes, has anti-inflammatory and immunosuppressive effects, participates in immune response, and plays a key role in extracellular matrix (ECM) protein synthesis. ECM dysregulation leads to fibroblast hyperproliferation and increased collagen synthesis and, consequently, tissue fibrosis. The variability of the diagnostic and prognostic potential of TGF-β1 has been demonstrated in studies on recipients of various solid organs. The objective of this review is to analyze recent evidence on the role of TGF-β1 in the development of post-transplant complications and to assess its prospects as a marker of graft pathology or as a target for therapy.Клинические результаты трансплантации солидных органов зависят от многих факторов, и главным среди них остается риск развития посттрансплантационных осложнений, ограничивающих выживаемость аллотрансплантата и реципиента. Концепция многофакторности повреждения органа при развитии посттрансплантационных осложнений и поиск диагностических и прогностических индикаторов патологии способствовали изучению и отбору широкого спектра протеомных и молекулярно-генетических биомаркеров, показавших эффективность при трансплантации солидных органов. Применение биомаркеров открывает дополнительные возможности для оценки риска осложнений и ранней диагностики последних, что потенциально способствует сокращению частоты инвазивных диагностических процедур. Трансформирующий фактор роста-β1 (TGF-β1) регулирует множество биологических процессов, обладает противовоспалительным и иммуносупрессивным действием, участвует в развитии иммунного ответа, а также играет ключевую роль в синтезе белков внеклеточного матрикса, дисрегуляция которого приводит к гиперпролиферации фибробластов и повышенному синтезу коллагена, и как следствие к фиброзу тканей. Вариативность диагностического и прогностического потенциала TGF-β1 показана в результатах исследований реципиентов различных солидных органов. Целью настоящего обзора стал анализ последних данных о роли TGF-β1 в развитии посттрансплантационных осложнений, а также оценка перспективы его применения как маркера патологии трансплантата или в качестве мишени для терапии

Розробка методик кількісного визначення фузидієвої кислоти та пантенолу в складі дерматологічного гелю «Фузипам-дерма»

Aim. To develop and validate the methods for the quantitative determination of fusidic acid and panthenol in “Fuzipam-derma” gel.Materials and methods. The determination was performed by high performance liquid chromatography (HPLC) according to the requirements of the State Pharmacopoeia of Ukraine (SPhU) 1.0 on a Prostar-210 liquid chromatograph, (Varian Chromatography System, USA).Results and discussion. The methods for the quantitative determination of fusidic acid and panthenol in “Fuzipam-derma” gel have been developed. The appropriate chromatographic conditions have been chosen, due to them the peaks of fusidic acid and panthenol are completely separated from other gel components. The validation of the methods for the quantitative determination of fusidic acid and panthenol has been performed. The data obtained have shown that the methods are stable and reproducible in different days.Conclusions. The methods for the quantitative determination of fusidic acid and panthenol in the composition of the new dermatological gel “Fuzipam-derma” for the treatment of grade І-ІІ acne has been developed using the HPLC method.Цель. Разработать и провести валидацию методик количественного определения фузидиевой кислоты и пантенола в геле «Фузипам-дерма».Материалы и методы. Определение проводили методом высокоэффективной жидкостной хроматографии в соответствии с требованиями ДФУ 1.0 на жидкостном хроматографе «Prostar-210» фирмы «Varian Chromatography System», США.Результаты и их обсуждение. Разработаны методики количественного определения фузидиевой кислоты и пантенола в геле «Фузипам-дерма». Были подобраны соответствующие условия хроматографирования, за счет которых пики фузидиевой кислоты и пантенола полностью отделялись от других компонентов геля. Была проведена валидация методик количественного определения фузидиевой кислоты и пантенола. Полученные данные показали, что методики являются стабильными и воспроизводятся в разные дни.Выводы. С помощью метода ВЭЖХ разработаны методики количественного определения фузидиевой кислоты и пантенола в составе нового дерматологического геля «Фузипам-дерма» для лечения I-II степени угревой болезни.Мета. Розробити та провести валідацію методик кількісного визначення фузидієвої кислоти та пантенолу у гелі «Фузипам-дерма».Матеріали та методи. Визначення проводили методом високоефективної рідинної хроматографії  згідно з вимогами ДФУ 1.0 на рідинному хроматографі «Prostar-210» фірми «Varian Chromatography System», США.Результати та їх обговорення. Розроблені методики кількісного визначення фузидієвої кислоти та пантенолу у гелі «Фузипам-дерма». Були підібрані відповідні умови хроматографування, за рахунок яких пiки фузидієвої кислоти та пантенолу повнiстю вiдокремлюються вiд iнших компонентiв гелю. Була проведена валiдацiя методик кiлькiсного визначення фузидієвої кислоти та пантенолу. Отриманi данi показали, що методики є стабiльними та вiдтворюються у рiзнi днi.Висновки. За допомогою методу ВЕРХ розроблені методики кількісного визначення фузидієвої кислоти та пантенолу в складі нового дерматологічного гелю «Фузипам-дерма» для лікування І-ІІ ступеня вугрової хвороби

Carbon Sequestration Dynamics in Urban-Adjacent Forests: A 50-Year Analysis

Achieving carbon neutrality is crucial for urban ecosystems. Forests growing near cities largely determine the state of the environment in urban areas. The aim of the present research is to assess the carbon productivity dynamics in forests near Krasnoyarsk (a large industrial center) over a 50-year period in terms of carbon sequestration and conservation. The study was based on forest inventory conducted in Karaul'noe Forestry in 1972, 1982, and 2002 and forest inventory covering six forest compartments in 2022. The forest covers 3980 ha and consists of 52 forest compartments. The analysis was based on the assessment of carbon productivity dynamics and followed four levels of principles: forestry, structure, forest compartment, and forest stand. The research was based on forest fund dynamics, analyzing methods, long-term forest inventory, assessing carbon stock, and growing stock dynamics. Pine is the dominant forest-forming species that absorbs the most carbon in the study area. Pine is long-lived, covers a vast area, and has the highest carbon sequestration potential. At the forest structure level, the predominant carbon pools are mid-late successional and late successional stands dominated by pine, birch, and aspen. Forest compartment-level analysis revealed three trends in carbon sequestration: carbon balance, a decrease in carbon sequestration, and an increase in carbon sequestration. Notably, the prevailing trend is determined by changes in carbon sequestration by dominant forest-forming species (pine). Forest stand-level analysis showed that stands have become more and more uneven-aged. About 65% of total carbon stock is concentrated in mid successional, mid-late successional and late-successional stands, and 35% in young stands. The carbon sequestration rate decreases in forests with age. However, pine forests increase biological productivity and continue to successfully sequester carbon. Deciduous forests have lost their carbon sequestration potential, and the area they occupy is currently decreasing in the study area. The development of the young generation in pine stands suggests that the carbon sequestration potential in forests growing near the city will not decrease and may even increase due to climate change. Doi: 10.28991/CEJ-2023-09-09-08 Full Text: PD

Complex-Radical Terpolymerization of Maleic Anhydride (Styrene), Allyl Propionate and Methyl Methacrylate

The radical terpolymerization reactions of the acceptor-donor-acceptor and donor-acceptor-donor systems, maleic anhydride (MA)-allyl propionate (AP)-methyl methacrylate (MMA) and styrene (St)-MMA-AP, had been studied. The terpolymerizations were carried out in methyl ethyl ketone at 60-75 °C in the presence of 2,2’-azoisobutyronitrile (ABIN) used as the initiator. Some kinetic parameters and copolymerization constants - for both, system were determined by dilatometric and Kelen-Tudos or Seiner-Lift methods. The obtained results are discussed in terms of the free monomer and complex chain growth models. It is shown that terpolymerization was carried out at a stage close to binary copolymerization of MA...AP complex with free MMA and St...MMA complex with AP in the both studied system, respectively. These systems are also used as model for interpretation of cyclocopolymerization mechanism in allyl methactylate-MA (or St) system. DTA and TGA analyses indicated the relatively high thermal stability of St-MMA-AP terpolymer. It is shown that this terpolymer decomposes through a one-step reaction at 310 °C, however MA-AP-MMA terpolymer decomposes through a multi-step reactions at 150, 260 and 310 °C

Physical properties of thermoelectric zinc antimonide using first-principles calculations

We report first principles calculations of the structural, electronic, elastic and vibrational properties of the semiconducting orthorhombic ZnSb compound. We study also the intrinsic point defects in order to eventually improve the thermoelectric properties of this already very promising thermoelectric material. Concerning the electronic properties, in addition to the band structure, we show that the Zn (Sb) crystallographically equivalent atoms are not exactly equivalent from the electronic point of view. Lattice dynamics, elastic and thermodynamic properties are found to be in good agreement with experiments and they confirm the non equivalency of the zinc and antimony atoms from the vibrational point of view. The calculated elastic properties show a relatively weak anisotropy and the hardest direction is the y direction. We observe the presence of low energy modes involving both Zn and Sb atoms at about 5-6 meV, similarly to what has been found in Zn4Sb3 and we suggest that the interactions of these modes with acoustic phonons could explain the relatively low thermal conductivity of ZnSb. Zinc vacancies are the most stable defects and this explains the intrinsic p-type conductivity of ZnSb.Comment: 33 pages, 8 figure