531 research outputs found
Copper cable theft: revisiting the price–theft hypothesis
Objectives: To test the commonly espoused but little examined hypothesis that fluctuations in the price of metal are associated with changes in the volume of metal theft. Specifically, we analyze the relationship between the price of copper and the number of police recorded 'live’ copper cable thefts from the British railway network (2006 to 2012)
Deep proteogenomics; high throughput gene validation by multidimensional liquid chromatography and mass spectrometry of proteins from the fungal wheat pathogen Stagonospora nodorum
BACKGROUND: Stagonospora nodorum, a fungal ascomycete in the class dothideomycetes, is a
damaging pathogen of wheat. It is a model for necrotrophic fungi that cause necrotic symptoms via
the interaction of multiple effector proteins with cultivar-specific receptors. A draft genome
sequence and annotation was published in 2007. A second-pass gene prediction using a training set
of 795 fully EST-supported genes predicted a total of 10762 version 2 nuclear-encoded genes, with
an additional 5354 less reliable version 1 genes also retained.
RESULTS: In this study, we subjected soluble mycelial proteins to proteolysis followed by 2D LC
MALDI-MS/MS. Comparison of the detected peptides with the gene models validated 2134 genes.
62% of these genes (1324) were not supported by prior EST evidence. Of the 2134 validated genes,
all but 188 were version 2 annotations. Statistical analysis of the validated gene models revealed a
preponderance of cytoplasmic and nuclear localised proteins, and proteins with intracellularassociated
GO terms. These statistical associations are consistent with the source of the peptides
used in the study. Comparison with a 6-frame translation of the S. nodorum genome assembly
confirmed 905 existing gene annotations (including 119 not previously confirmed) and provided
evidence supporting 144 genes with coding exon frameshift modifications, 604 genes with
extensions of coding exons into annotated introns or untranslated regions (UTRs), 3 new gene
annotations which were supported by tblastn to NR, and 44 potential new genes residing within
un-assembled regions of the genome.
CONCLUSION: We conclude that 2D LC MALDI-MS/MS is a powerful, rapid and economical tool to
aid in the annotation of fungal genomic assemblies
Nodal Landau Fermi-Liquid Quasiparticles in Overdoped LaSrCuO
Nodal angle resolved photoemission spectra taken on overdoped
LaSrCuO are presented and analyzed. It is proven that the
low-energy excitations are true Landau Fermi-liquid quasiparticles. We show
that momentum and energy distribution curves can be analyzed self-consistently
without quantitative knowledge of the bare band dispersion. Finally, by
imposing Kramers-Kronig consistency on the self-energy , insight into
the quasiparticle residue is gained. We conclude by comparing our results to
quasiparticle properties extracted from thermodynamic, magneto-resistance, and
high-field quantum oscillation experiments on overdoped
TlBaCuO.Comment: Accepted for publication in Phys. Rev.
Spin fluctuations associated with the collapse of the pseudogap in a cuprate superconductor
Theories of the origin of superconductivity in cuprates are dependent on an
understanding of their normal state which exhibits various competing orders.
Transport and thermodynamic measurements on LaSrCuO show
signatures of a quantum critical point, including a peak in the electronic
specific heat versus doping p, near the doping p*, where the pseudogap
collapses. The fundamental nature of the fluctuations associated with this peak
is unclear. Here we use inelastic neutron scattering to show that close to
and near p*, there are low-energy collective spin excitations with
characteristic energies 5 meV. The correlation length of the spin
fluctuations does not diverge in spite of the low energy scale and we conclude
that the underlying quantum criticality is not due to antiferromagnetism but
most likely to a collapse of the pseudogap. We show that the large specific
heat near p* can be understood in terms of collective spin fluctuations. The
spin fluctuations we measure exist across the superconducting phase diagram and
may be related to the strange metal behaviour observed in overdoped cuprates
A Right to ‘Dying Well’ with Dementia? Capacity, ‘Choice’ and Relationality.
A right to 'dying well' with dementia? Capacity, 'choice' and relationalit
Self-gravitating clouds of generalized Chaplygin and modified anti-Chaplygin Gases
The Chaplygin gas has been proposed as a possible dark energy, dark matter
candidate. As a working fluid in a Friedmann-Robertson-Walker universe, it
exhibits early behavior reminiscent of dark matter, but at later times is more
akin to a cosmological constant. In any such universe, however, one can expect
local perturbations to form. Here we obtain the general equations for a
self-gravitating relativistic Chaplygin gas. We solve these equations and
obtain the mass-radius relationship for such structures, showing that only in
the phantom regime is the mass-radius relationship large enough to be a serious
candidate for highly compact massive objects at the galaxy core. In addition,
we study the cosmology of a modified anti-Chaplygin gas. A self-gravitating
cloud of this matter is an exact solution to Einstein's equations.Comment: 16 page
Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program
BACKGROUND: Single pulse transcranial magnetic stimulation (sTMS) is a novel treatment for acute migraine. Previous randomised controlled data demonstrated that sTMS is effective and well tolerated in the treatment of migraine with aura. The aim of the programme reported here was to evaluate patient responses in the setting of routine clinical practice. METHODS: Migraine patients with and without aura treating with sTMS had an initial review (n = 426) and training call, and then participated in telephone surveys at week six (n = 331) and week 12 during a 3-month treatment period (n = 190). RESULTS: Of patients surveyed with 3 month data (n = 190; episodic, n = 59; chronic, n = 131), 62 % reported pain relief, finding the device effective at reducing or alleviating migraine pain; in addition there was relief reported of associated features: nausea- 52 %; photophobia- 55 %; and phonophobia- 53 %. At 3 months there was a reduction in monthly headache days for episodic migraine, from 12 (median, 8–13 IQ range) to 9 (4–12) and for chronic migraine, a reduction from 24 (median, 16–30 IQ range) to 16 (10–30). There were no serious or unanticipated adverse events. CONCLUSION: sTMS may be a valuable addition to options for the treatment of both episodic and chronic migraine
Spin density wave induced disordering of the vortex lattice in superconducting LaSrCuO
We use small angle neutron scattering to study the superconducting vortex
lattice in LaSrCuO as a function of doping and magnetic field.
We show that near optimally doping the vortex lattice coordination and the
superconducting coherence length are controlled by a van-Hove singularity
crossing the Fermi level near the Brillouin zone boundary. The vortex lattice
properties change dramatically as a spin-density-wave instability is approached
upon underdoping. The Bragg glass paradigm provides a good description of this
regime and suggests that SDW order acts as a novel source of disorder on the
vortex lattice.Comment: Accepted in Phys. Rev.
Deep proteogenomics; high throughput gene validation by multidimensional liquid chromatography and mass spectrometry of proteins from the fungal wheat pathogen Stagonospora nodorum
Background
Stagonospora nodorum, a fungal ascomycete in the class dothideomycetes, is a damaging pathogen of wheat. It is a model for necrotrophic fungi that cause necrotic symptoms via the interaction of multiple effector proteins with cultivar-specific receptors. A draft genome sequence and annotation was published in 2007. A second-pass gene prediction using a training set of 795 fully EST-supported genes predicted a total of 10762 version 2 nuclear-encoded genes, with an additional 5354 less reliable version 1 genes also retained.
Results
In this study, we subjected soluble mycelial proteins to proteolysis followed by 2D LC MALDI-MS/MS. Comparison of the detected peptides with the gene models validated 2134 genes. 62% of these genes (1324) were not supported by prior EST evidence. Of the 2134 validated genes, all but 188 were version 2 annotations. Statistical analysis of the validated gene models revealed a preponderance of cytoplasmic and nuclear localised proteins, and proteins with intracellular-associated GO terms. These statistical associations are consistent with the source of the peptides used in the study. Comparison with a 6-frame translation of the S. nodorum genome assembly confirmed 905 existing gene annotations (including 119 not previously confirmed) and provided evidence supporting 144 genes with coding exon frameshift modifications, 604 genes with extensions of coding exons into annotated introns or untranslated regions (UTRs), 3 new gene annotations which were supported by tblastn to NR, and 44 potential new genes residing within un-assembled regions of the genome.
Conclusion
We conclude that 2D LC MALDI-MS/MS is a powerful, rapid and economical tool to aid in the annotation of fungal genomic assemblies
Three-Dimensional Fermi Surface of Overdoped La-Based Cuprates
We present a soft x-ray angle-resolved photoemission spectroscopy study of
the overdoped high-temperature superconductors LaSrCuO and
LaEuSrCuO. In-plane and out-of-plane components of
the Fermi surface are mapped by varying the photoemission angle and the
incident photon energy. No dispersion is observed along the nodal
direction, whereas a significant antinodal dispersion is identified.
Based on a tight-binding parametrization, we discuss the implications for the
density of states near the van-Hove singularity. Our results suggest that the
large electronic specific heat found in overdoped LaSrCuO can
not be assigned to the van-Hove singularity alone. We therefore propose quantum
criticality induced by a collapsing pseudogap phase as a plausible explanation
for observed enhancement of electronic specific heat
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