Alterações ecocardiográficas causadas pelo uso da romifidina em potros árabes

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Fully Inkjet-Printed Green-Emitting PEDOT:PSS/NiO/Colloidal CsPbBr3/SnO2 Perovskite Light-Emitting Diode on Rigid and Flexible Substrates

After establishing themselves as promising active materials in the field of solar cells, halide perovskites are currently being explored for fabrication of low-cost, easily processable, and highly efficient light-emitting diodes (LEDs). Despite this, the highest efficiencies reported for perovskite-based LEDs (PeLEDs) are achieved through spin coating or vacuum evaporation deposition techniques, which are not adequate, in most of the cases, for an industrial-scale production. Additionally, the long-term stability is still a big handicap, even though all inorganic perovskites, such as CsPbBr3, are found to be more stable to external variables. In this context, herein, the fabrication of fully inkjet-printed (IJP) CsPbBr3-based PeLEDs in ambient conditions, on rigid and flexible substrates, on a proof-of-concept basis, with the successful incorporation of NiO and SnO2 as hole- and electron-selective contacts, respectively, is reported. Despite the moderate luminance (324 cd m−2) value obtained, this result paves the way toward the development of upscalable fabrication of PeLEDs based on deposition techniques with controlled spatial resolution.The authors wish to thank the financial support from the European Commission via FET Open Grant (862656, DROP-IT), MINECO (Spain) for grant PID2019-105658RB-I00 (PRITES project), Ministry of Science and Innovation of Spain under Project STABLE (PID2019-107314RB-I00), and Generalitat Valenciana via Prometeo Grant Q-Devices (Prometeo/2018/098)

Plasma and synovial fluid extracellular vesicles display altered microRNA profiles in horses with naturally occurring post-traumatic osteoarthritis: an exploratory study.

ObjectiveThe objective of this study was to characterize extracellular vesicles (EVs) in plasma and synovial fluid obtained from horses with and without naturally occurring post-traumatic osteoarthritis (PTOA).AnimalsEVs were isolated from plasma and synovial fluid from horses with (n = 6) and without (n = 6) PTOA.MethodsPlasma and synovial fluid EVs were characterized with respect to quantity, size, and surface markers. Small RNA sequencing was performed, and differentially expressed microRNAs (miRNAs) underwent bioinformatic analysis to identify putative targets and to explore potential associations with specific biological processes.ResultsPlasma and synovial fluid samples from horses with PTOA had a significantly higher proportion of exosomes and a lower proportion of microvesicles compared to horses without PTOA. Small RNA sequencing revealed several differentially expressed miRNAs, including miR-144, miR-219-3p, and miR-199a-3l in plasma and miR-199a-3p, miR-214, and miR-9094 in synovial fluid EVs. Bioinformatics analysis of the differentially expressed miRNAs highlighted their potential role in fibrosis, differentiation of chondrocytes, apoptosis, and inflammation pathways in PTOA.Clinical relevanceWe have identified dynamic molecular changes in the small noncoding signatures of plasma and synovial fluid EVs in horses with naturally occurring PTOA. These findings could serve to identify promising biomarkers in the pathogenesis of PTOA, to facilitate the development of targeted therapies, and to aid in establishing appropriate translational models of PTOA

Can Tailored Communications Motivate Volunteers? A Field Experiment

Over 25% of the US population volunteers. Clary et al. (1998) devised a survey that identifies a volunteer’s primary motive for volunteering. We investigate the effect of tailoring the communications that volunteers receive from their organizations (e.g., printed newsletters, update emails) to each volunteer’s stated motive for volunteering affects volunteer performance. We find that in general, such tailoring has no effect, but that for volunteers who are motivated primarily by the pursuit of career-related benefits, such tailoring can have a substantial, positive effect on hours volunteered. We also find that the (in)effectiveness of this tailoring does not depend upon the volunteers’ knowledge of the tailoring. The tailoring of communications does not involve the explicit manipulation of material incentives. This renders it particularly attractive given the emergence of evidence on how extrinsic incentives can crowd out intrinsic incentives, especially in the domain of charitable contributions