A case of hyperplasia of the adrenal cortex in the newborn child

Clinical observation of a hyperplasia of the adrenal cortex in the newborn is presented. Main feature of this observation is the complicated course of this disease in the newborn against hypoxemic defeat of the central nervous system and neonatal jaundice. Now treatment of this congenital disease has to begin with the first week of life and includes complete hormonal and infusion therapy. In this observation child’s clinical improvement is noted

Genetic identification of cytomegaloviruses in a rural population of Côte d'Ivoire.

BACKGROUND: Cytomegaloviruses (CMVs) are herpesviruses that infect many mammalian species, including humans. Infection generally passes undetected, but the virus can cause serious disease in individuals with impaired immune function. Human CMV (HCMV) is circulating with high seroprevalence (60-100 %) on all continents. However, little information is available on HCMV genoprevalence and genetic diversity in subsaharan Africa, especially in rural areas of West Africa that are at high risk of human-to-human HCMV transmission. In addition, there is a potential for zoonotic spillover of pathogens through bushmeat hunting and handling in these areas as shown for various retroviruses. Although HCMV and nonhuman CMVs are regarded as species-specific, potential human infection with CMVs of non-human primate (NHP) origin, shown to circulate in the local NHP population, has not been studied. FINDINGS: Analysis of 657 human oral swabs and fecal samples collected from 518 individuals living in 8 villages of Côte d'Ivoire with generic PCR for identification of human and NHP CMVs revealed shedding of HCMV in 2.5 % of the individuals. Determination of glycoprotein B sequences showed identity with strains Towne, AD169 and Toledo, respectively. NHP CMV sequences were not detected. CONCLUSIONS: HCMV is actively circulating in a proportion of the rural Côte d'Ivoire human population with circulating strains being closely related to those previously identified in non-African countries. The lack of NHP CMVs in human populations in an environment conducive to cross-species infection supports zoonotic transmission of CMVs to humans being at most a rare event

Features of the order-disorder phase transition during the ordering of Ni4Mo and Ni4W alloys with D1a superstructure

Results are presented from studying atomic long-range order in Ni4Mo and Ni4W alloys via X-ray diffraction analysis. The phase transitions in these alloys are confirmed to be of the D1a → A1 type. The temperature dependences of the long-range order parameters are found to be similar in Ni4Mo and Ni4W alloys. The difference between their properties is due to different characters of the order–disorder phase transition. A transition from the single-phase state with D1a superstructure to single-phase А1 through the diphase (D1a → A1) region occurs in the Ni4Mo alloy. A more complex D1a → (A1 + δ) peritectoid transformation takes place in the Ni4W alloy. It is shown that an order parameter equal to unity can be obtained in Ni4Mo alloy through long-term ordering annealing, while such long-range order in Ni4W alloy (ηmax = 0.9) is impossible to obtain by annealing

Features of the order-disorder phase transition during the ordering of Ni4Mo and Ni4W alloys with D1a superstructure

Results are presented from studying atomic long-range order in Ni4Mo and Ni4W alloys via X-ray diffraction analysis. The phase transitions in these alloys are confirmed to be of the D1a → A1 type. The temperature dependences of the long-range order parameters are found to be similar in Ni4Mo and Ni4W alloys. The difference between their properties is due to different characters of the order–disorder phase transition. A transition from the single-phase state with D1a superstructure to single-phase А1 through the diphase (D1a → A1) region occurs in the Ni4Mo alloy. A more complex D1a → (A1 + δ) peritectoid transformation takes place in the Ni4W alloy. It is shown that an order parameter equal to unity can be obtained in Ni4Mo alloy through long-term ordering annealing, while such long-range order in Ni4W alloy (ηmax = 0.9) is impossible to obtain by annealing

A case of neonatal jaundice in the newborn child with burdened somatic background

Jaundice is one of the most frequent metabolic disorders detected in the newborn period. Neonatal jaundice is most likely to be physiological, it is a transient condition and does not require treatment, at the same time it can be a symptom of a serious disease which requires diagnosis and therapy. It is presented a clinical case of conjugational jaundice in newborn from mother with diabetes, with manifestations of hemorrhagic disease. The peculiarity of this case is a complicated course of this disease with hypoxic lesions of the central nervous system and partial intestinal obstruction. In this observation it is shown the effectiveness of the therapy with early diagnosis of the disease and the complications before the appearance of the developed clinical picture

INFLUENCE OF MILDRONATE ON EFFICIENCY OF ANTIANGINAL THERAPY IN PATIENTS WITH STABLE BURDEN ANGINA

Aim. To study influence of mildronate (M) on treatment efficiency of patients with ischemic heart disease (IHD), receiving standard antianginal therapy (AAT)Materials and methods. Double-blind, randomized, placebo-controlled study was carried out in parallel groups. All patients continued the earlier prescribed AAT without changes. After control period (10-14 days) was over, randomization of patients either to the treatment group (M 500mg twice per day), or to the control group (placebo (Pl) twice per day) was made for 6 weeks therapy. Criterion of treatment efficiency: increase in duration of trial with burden on treadmill (TB), decrease in angina attack frequency (AA) and reduction in nitroglycerin taking (NTT). TB was carried out at the beginning (TB-1), at the end of the control period (TB-2), and at the end of the treatment (TB-3).Results. TB-1 and TB-2 had good reproducibility, their duration didn’t differ. At the end of the treatment additionally with M, growth in duration of TB-3 (p=0,002) was registered, while there was no growth of TB duration with the Pl treatment (p=0,07). During the treatment decrease in AA number both with M (p=0,002), and with Pl (p=0,02) was noted. With M treatment decrease in NTT treatment (p=0.02) was observed, while NTT with Pl didn’t change (p=0,7). Number of side effects, registered with M and Pl, didn’t differ.Conclusion. Mildronate provides additional benefits for patients with IHD with stable burden angina, when they do not reach desired effect with the prescribed AAT