Endogenous driving and synchronization in cardiac and uterine virtual tissues: bifurcations and local coupling

Cardiac and uterine muscle cells and tissue can be either autorhythmic or excitable. These behaviours exchange stability at bifurcations produced by changes in parameters, which if spatially localized can produce an ectopic pacemaking focus. The effects of these parameters on cell dynamics have been identified and quantified using continuation algorithms and by numerical solutions of virtual cells. The ability of a compact pacemaker to drive the surrounding excitable tissues depends on both the size of the pacemaker and the strength of electrotonic coupling between cells within, between, and outside the pacemaking region. We investigate an ectopic pacemaker surrounded by normal excitable tissue. Cell–cell coupling is simulated by the diffusion coefficient for voltage. For uniformly coupled tissues, the behaviour of the hybrid tissue can take one of the three forms: (i) the surrounding tissue electrotonically suppresses the pacemaker; (ii) depressed rate oscillatory activity in the pacemaker but no propagation; and (iii) pacemaker driving propagations into the excitable region. However, real tissues are heterogeneous with spatial changes in cell–cell coupling. In the gravid uterus during early pregnancy, cells are weakly coupled, with the cell–cell coupling increasing during late pregnancy, allowing synchronous contractions during labour. These effects are investigated for a caricature uterine tissue by allowing both excitability and diffusion coefficient to vary stochastically with space, and for cardiac tissues by spatial gradients in the diffusion coefficient

Ayurveda management of Rheumatoid Arthritis - A Case Study

Rheumatoid Arthritis is an autoimmune disease that can cause joint pain and damage throughout the body. Rheumatoid Arthritis is a chronic inflammatory disorder that can affect more on joints. As per Ayurvedic science Rheumatoid Arthritis sign and symptoms resemblance with Aamvata. Aamvata is the disease caused by impairment of Agni, formation of Ama and vitiation of Vatadosha. There is limited treatment in modern science for rheumatoid arthritis. Ayurveda treatment has the best result for Amavata. So in this case study Ayurveda treatment has used to cure Aamvata

Ayurveda management of Psoriasis - A Case Study

Psoriasis is an autoimmune disorder of skin, results in hyper proliferation of the skin. It is a chronic skin disease characterized by dry skin and raised, rough, red areas on the skin covered with fine silvery scales. A clear skin description is available in Charaka Samhita under Kushtha. Ayurved management is quite effective in Psoriasis as compared to modern treatment. The line of treatment in present given study is Shodhana and Shamana Chikitsa. Virechana therapy followed by internal medicinal treatment is considered as good management of skin disorder

Secure Effective Detection Approach for Detecting Malicious Facebook Application

Third-party apps square measure a significant reason for the recognition and addictiveness of Facebook. Sadly, hackers have accomplished the potential of exploitation apps for spreading malware and spam. As we discover that a minimum of thirteen of apps in our knowledge square measure malicious. So far, the analysis community has targeted on detective work malicious posts and campaigns. During this paper, we have a tendency to raise the question: Given a Facebook application, will we have a tendency to confirm if it's malicious? Our key contribution is in developing FRAppE?Facebook?s Rigorous Application authority the primary tool targeted on detective work malicious apps on Facebook. To develop FRAppE, we have a tendency to use info gathered by perceptive the posting behavior of 111K Facebook apps seen across 2.2 million users on Facebook. First, we have a tendency to establish a collection of options that facilitate U.S. distinguish malicious apps from benign ones. For instance, we discover that malicious apps typically share names with different apps, and that they usually request less permission than benign apps. Second, investment these distinctive options, we have a tendency to show that FRAppE will discover malicious apps with ninety nine accuracy

Engineered valley-orbit splittings in quantum confined nanostructures in silicon

An important challenge in silicon quantum electronics in the few electron regime is the potentially small energy gap between the ground and excited orbital states in 3D quantum confined nanostructures due to the multiple valley degeneracies of the conduction band present in silicon. Understanding the "valley-orbit" (VO) gap is essential for silicon qubits, as a large VO gap prevents leakage of the qubit states into a higher dimensional Hilbert space. The VO gap varies considerably depending on quantum confinement, and can be engineered by external electric fields. In this work we investigate VO splitting experimentally and theoretically in a range of confinement regimes. We report measurements of the VO splitting in silicon quantum dot and donor devices through excited state transport spectroscopy. These results are underpinned by large-scale atomistic tight-binding calculations involving over 1 million atoms to compute VO splittings as functions of electric fields, donor depths, and surface disorder. The results provide a comprehensive picture of the range of VO splittings that can be achieved through quantum engineering.Comment: 4 pages, 4 figure

Antioxidant and spermatozoa: a complex story- A review

The artificial insemination is a common practice in domestic animals, but the use of frozen semen compromises the fertility of goat spermatozoa based on pregnancy rates from AI. This could be due to a poor resistance of goat spermatozoa to cryopreservation stresses compared to sperm from other domesticated mammals. Lipid peroxidation caused by reactive oxygen species limits the success in this species. Reports revealed that inclusion of antioxidants in cryopreservation media improved quality of semen against LPO. Moreover, inclusion of enzymatic and nonenzymatic antioxidants (vitamin C, glutathione reduced etc) in diluents at appropriate concentration can help in holding the semen at refrigeration temperature for many days

Investigation of ripple-limited low-field mobility in large-scale graphene nanoribbons

Combining molecular dynamics and quantum transport simulations, we study the degradation of mobility in graphene nanoribbons caused by substrate-induced ripples. First, the atom coordinates of large-scale structures are relaxed such that surface properties are consistent with those of graphene on a substrate. Then, the electron current and low-field mobility of the resulting non-flat nanoribbons are calculated within the Non-equilibrium Green\u27s Function formalism in the coherent transport limit. An accurate tight-binding basis coupling the sigma- and pi-bands of graphene is used for this purpose. It is found that the presence of ripples decreases the mobility of graphene nanoribbons on SiO2 below 3000 cm(2)/Vs, which is comparable to experimentally reported values. (C) 2013 AIP Publishing LLC

Soil biological properties as influenced by long-term manuring and fertilization under sorghum (Sorghum bicolor) -wheat (Triticum aestivum) sequence in Vertisols

The effect of long-term manuring and fertilization on soil biological properties was studied under the long term fertilizer experiment on sorghum [Sorghum bicolor (L.) Moench] -wheat (Triticum aestivum L.) sequence conducted on Vertisols. The treatments comprised 50% RDF, 100% RDF, 150% RDF,100% RDF (-S), 100% RDF + 2.5 kg Zn/ ha to wheat crop only, 100% RD of NP, 100% RD of N, 100% RDF + FYM @ 10 tonnes/ha, 100% RDF + S @ 37.5 kg/ ha, FYM @ 10 tonnes/ha, 75% RDF and control. The assessment of soil biological properties at 40 and 70 days after sowing revealed that, significantly highest CO2 evolution was recorded at 70 DAS of sorghum under 100% RDF + FYM @ 10 tonnes/ ha ( 66.82 mg/ 100 kg). Soil microbial biomass carbon was also influenced significantly with the combined application of NPK+FYM (278.9 mg/ kg). The soil enzyme activity, viz. dehydrogenase (55.01 µg TPF/g/24 hr), urease (47.9 mg NH4/kg/ 24 hr) and cellulase (52.23 µg glucose/g/24 hr) were significantly influenced with the application of 100% RDF + FYM @ 10 tonnes/ha. Similarly, the application of 100% RDF + FYM @ 10 tonnes/ha recorded significantly higher grain yield of sorghum

Ayurveda management of Osteo Arthritis (Sandhigata Vata) - A Case Study

Osteoarthritis is the most common form of arthritis affecting millions of people worldwide. It occurs when the protective cartilage that cushions the end of your bone wears down overtime. In Ayurveda osteoarthritis correlate to Sandhigat Vata. The common sign and symptoms of this disease is present in the form of Shoola, Shotha, Vatapoornadriti Sparsha and difficulty in flexion and extension of Sandhi. In modern science the available treatment is use of NSAID, Calcium supplement and finally replacement therapy. Due to this there are large no of patients suffering from this disease come towards Ayurveda. Ayurveda treatment by its Chikitsa Siddhant gives remarkable relief in osteoarthritis. In this case study a 60 yrs patient suffering from osteoarthritis of both knee joint got good relief