Modeling and Simulation of Machining-induced Surface Integrity Characteristicsof NiTi Alloy

AbstractNiTi shape memory alloys have gained increased interest in various industries, including biomedical and aerospace applications due to their unique properties such as shape memory effect and superelasticity. Martensitic phase transformation in NiTi significantly affects the surface integrity characteristics. This phase transformation needs to be better understood to control and enhance the shape memory and microstructural properties of NiTi shape memory alloys. This study presents results of combined experimentation and simulation of cutting-induced phase transformation in orthogonal machining of NiTi shape memory alloys. A phenomenological modeling approach was utilized to model machining-induced phase transformation. NiTi shape memory alloys alloy were in austenite phases at room temperature. The transformation during dry machining process from austenite to martensite phases, and the resulting volume fraction was successfully simulated using DEFORM 2-D software by implementing a user-defined subroutine. The developed model is capable of capturing the trend of variationsinvolume fracture and the depth of transformed layer as a function of cutting speed

Vitamin A as a Transcriptional Regulator of Cardiovascular Disease

Vitamin A is a micronutrient and signaling molecule that regulates transcription, cellular differentiation, and organ homeostasis. Additionally, metabolites of Vitamin A are utilized as differentiation agents in the treatment of hematological cancers and skin disorders, necessitating further study into the effects of both nutrient deficiency and the exogenous delivery of Vitamin A and its metabolites on cardiovascular phenotypes. Though vitamin A/retinoids are well-known regulators of cardiac formation, recent evidence has emerged that supports their role as regulators of cardiac regeneration, postnatal cardiac function, and cardiovascular disease progression. We here review findings from genetic and pharmacological studies describing the regulation of both myocyte- and vascular-driven cardiac phenotypes by vitamin A signaling. We identify the relationship between retinoids and maladaptive processes during the pathological hypertrophy of the heart, with a focus on the activation of neurohormonal signaling and fetal transcription factors (Gata4, Tbx5). Finally, we assess how this information might be leveraged to develop novel therapeutic avenues

Symbol calculus and zeta--function regularized determinants

In this work, we use semigroup integral to evaluate zeta-function regularized determinants. This is especially powerful for non--positive operators such as the Dirac operator. In order to understand fully the quantum effective action one should know not only the potential term but also the leading kinetic term. In this purpose we use the Weyl type of symbol calculus to evaluate the determinant as a derivative expansion. The technique is applied both to a spin--0 bosonic operator and to the Dirac operator coupled to a scalar field.Comment: Added references, some typos corrected, published versio

Relativistic Lee Model on Riemannian Manifolds

We study the relativistic Lee model on static Riemannian manifolds. The model is constructed nonperturbatively through its resolvent, which is based on the so-called principal operator and the heat kernel techniques. It is shown that making the principal operator well-defined dictates how to renormalize the parameters of the model. The renormalization of the parameters are the same in the light front coordinates as in the instant form. Moreover, the renormalization of the model on Riemannian manifolds agrees with the flat case. The asymptotic behavior of the renormalized principal operator in the large number of bosons limit implies that the ground state energy is positive. In 2+1 dimensions, the model requires only a mass renormalization. We obtain rigorous bounds on the ground state energy for the n-particle sector of 2+1 dimensional model.Comment: 23 pages, added a new section, corrected typos and slightly different titl

Computational aspects of zonal algorithms for solving the compressible Navier-Stokes equations in three dimensions

Transonic flow fields about wing geometries are computed using an Euler/Navier-Stokes approach in which the flow field is divided into several zones. The flow field immediately adjacent to the wing surface is resolved with fine grid zones and solved using a Navier-Stokes algorithm. Flow field regions removed from the wing are resolved with less finely clustered grid zones and are solved with an Euler algorithm. Computational issues associated with this zonal approach, including data base management aspects, are discussed. Solutions are obtained that are in good agreement with experiment, including cases with significant wind tunnel wall effects. Additional cases with significant shock induced separation on the upper wing surface are also presented

A novel dual reporter embryonic stem cell line for toxicological assessment of teratogen-induced perturbation of anterior-posterior patterning of the heart

Reliable in vitro models to assess developmental toxicity of drugs and chemicals would lead to improvement in fetal safety and a reduced cost of drug development. The validated embryonic stem cell test (EST) uses cardiac differentiation of mouse embryonic stem cells (mESCs) to predict in vivo developmental toxicity, but does not take into account the stage-specific patterning of progenitor populations into anterior (ventricular) and posterior (atrial) compartments. In this study, we generated a novel dual reporter mESC line with fluorescent reporters under the control of anterior and posterior cardiac promoters. Reporter expression was observed in nascent compartments in transgenic mouse embryos, and mESCs were used to develop differentiation assays in which chemical modulators of Wnt (XAV939: 3, 10 mu M), retinoic acid (all-trans retinoic acid: 0.1, 1, 10 mu M; 9-cis retinoic acid: 0.1, 1, 10 mu M; bexarotene 0.1, 1, 10 mu M), and Tgf-beta (SB431542: 3, 10 mu M) pathways were tested for stage- and dose-dependent effects on in vitro anterior-posterior patterning. Our results suggest that with further development, the inclusion of anterior-posterior reporter expression could be part of a battery of high-throughput tests used to identify and characterize teratogens.Peer reviewe

Control-based 4D printing: adaptive 4D-printed systems

Building on the recent progress of four-dimensional (4D) printing to produce dynamic structures, this study aimed to bring this technology to the next level by introducing control-based 4D printing to develop adaptive 4D-printed systems with highly versatile multi-disciplinary applications, including medicine, in the form of assisted soft robots, smart textiles as wearable electronics and other industries such as agriculture and microfluidics. This study introduced and analysed adaptive 4D-printed systems with an advanced manufacturing approach for developing stimuli-responsive constructs that organically adapted to environmental dynamic situations and uncertainties as nature does. The adaptive 4D-printed systems incorporated synergic integration of three-dimensional (3D)-printed sensors into 4D-printing and control units, which could be assembled and programmed to transform their shapes based on the assigned tasks and environmental stimuli. This paper demonstrates the adaptivity of these systems via a combination of proprioceptive sensory feedback, modeling and controllers, as well as the challenges and future opportunities they present

String Theory in the Penrose Limit of AdS_2 x S^2

The string theory in the Penrose limit of AdS_2 x S^2 is investigated. The specific Penrose limit is the background known as the Nappi-Witten spacetime, which is a plane-wave background with an axion field. The string theory on it is given as the Wess-Zumino-Novikov-Witten (WZNW) model on non-semi-simple group H_4. It is found that, in the past literature, an important type of irreducible representations of the corresponding algebra, h_4, were missed. We present this "new" representations, which have the type of continuous series representations. All the three types of representations of the previous literature can be obtained from the "new" representations by setting the momenta in the theory to special values. Then we realized the affine currents of the WZNW model in terms of four bosonic free fields and constructed the spectrum of the theory by acting the negative frequency modes of free fields on the ground level states in the h_4 continuous series representation. The spectrum is shown to be free of ghosts, after the Virasoro constraints are satisfied. In particular we argued that there is no need for constraining one of the longitudinal momenta to have unitarity. The tachyon vertex operator, that correspond to a particular state in the ground level of the string spectrum, is constructed. The operator products of the vertex operator with the currents and the energy-momentum tensor are shown to have the correct forms, with the correct conformal weight of the vertex operator.Comment: 30 pages, Latex, no figure

Effects of topology optimization in multimaterial 3D bioprinting of soft actuators

Recently, there has been a proliferation of soft robots and actuators that exhibit improved capabilities and adaptability through three-dimensional (3D) bioprinting. Flexibility and shape recovery attributes of stimuli-responsive polymers as the main components in the production of these dynamic structures enable soft manipulations in fragile environments, with potential applications in biomedical and food sectors. Topology optimization (TO), when used in conjunction with 3D bioprinting with optimal design features, offers new capabilities for efficient performance in compliant mechanisms. In this paper, multimaterial TO analysis is used to improve and control the bending performance of a bioprinted soft actuator with electrolytic stimulation. The multimaterial actuator performance is evaluated by the amplitude and rate of bending motion and compared with the single material printed actuator. The results demonstrated the efficacy of multimaterial 3D bioprinting optimization for the rate of actuation and bending