A Non - Singular Cosmological Model with Shear and Rotation

We have investigated a non-static and rotating model of the universe with an imperfect fluid distribution. It is found that the model is free from singularity and represents an ever expanding universe with shear and rotation vanishing for large value of time.Comment: 10 pages, late

Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer

Liver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not surgical candidates and/or fail systemic chemotherapy, liver-directed therapies are increasingly being utilized. Yttrium-90 (Y-90) microsphere therapy, also known as selective internal radiation therapy (SIRT) or radioembolization, has proven to be effective in terms of extending time to progression of disease and also providing survival benefit. This review focuses on the use of Y-90 microsphere therapy in the treatment of liver metastases from CRC, including a comprehensive review of published clinical trials and prospective studies conducted thus far. We review the methodology, outcomes, and side effects of Y-90 microsphere therapy for metastatic CRC

Model of LPG Refrigerator: A Literature Review

This work investigates the result of an experimental study carried out to determine the Coefficient of performance of domestic refrigerator when a propane-butane mixture is liquefied petroleum gas (LPG) which is available and comprises 56.4% butane, 24.4%propane, and 17.2% isobutene. This paper also presented an experimental investigation of COP by the effect of changing capillary tube length, capillary tube inner diameter and capillary coil diameter on the mass flow rate of refrigerant in an adiabatic helical capillary tube. Large amount of electricity supply is not available easily in large part of underdevelopment country like India. It will also prove to be an effective for remote area such as research sites, mines, & deserts where electricity is generally not available. The LPG is cheaper and possesses an environmental free in nature with no ozone depletion potential (ODP). Also LPG is available as a side product in local refineries. The results of the present work indicate the successful use of this propane-butane mixture as an alternative refrigerant to CFCs and HFCs in domestic refrigerator. It would include Experimental setup of working model and detailed observation of the LPG refrigerator and represents its application in refinery, hotel, chemical industries where requirement of LPG is more. Keywords: LPG refrigerator, domestic refrigerator, eco friendly refrigerants, Mixed Refrigerant

Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury.

Perioperative bleeding is a potentially devastating complication in neurosurgical patients, and plasma fibrinogen concentration has been identified as a potential modifiable risk factor for perioperative bleeding. The aim of this study was to evaluate preconditioning with Crotalus atrox venom (Cv-PC) as potential preventive therapy for reducing perioperative hemorrhage in the rodent model of surgical brain injury (SBI). C. atrox venom contains snake venom metalloproteinases that cleave fibrinogen into fibrin split products without inducing clotting. Separately, fibrinogen split products induce fibrinogen production, thereby elevating plasma fibrinogen levels. Thus, the hypothesis was that preconditioning with C. atrox venom will produce fibrinogen spilt products, thereby upregulating fibrinogen levels, ultimately improving perioperative hemostasis during SBI. We observed that Cv-PC SBI animals had significantly reduced intraoperative hemorrhage and postoperative hematoma volumes compared to those of vehicle preconditioned SBI animals. Cv-PC animals were also found to have higher levels of plasma fibrinogen at the time of surgery, with unchanged prothrombin time. Cv-PC studies with fractions of C. atrox venom suggest that snake venom metalloproteinases are largely responsible for the improved hemostasis by Cv-PC. Our findings indicate that Cv-PC increases plasma fibrinogen levels and may provide a promising therapy for reducing perioperative hemorrhage in elective surgeries

Thermal Particle Creation in Cosmological Spacetimes: A Stochastic Approach

The stochastic method based on the influence functional formalism introduced in an earlier paper to treat particle creation in near-uniformly accelerated detectors and collapsing masses is applied here to treat thermal and near-thermal radiance in certain types of cosmological expansions. It is indicated how the appearance of thermal radiance in different cosmological spacetimes and in the two apparently distinct classes of black hole and cosmological spacetimes can be understood under a unifying conceptual and methodological framework.Comment: 17 pages, revtex (aps, eqsecnum), submitted to PRD, April 199

Objective response to immune checkpoint inhibitor therapy in NRAS-mutant melanoma: A systematic review and meta-analysis

INTRODUCTION: METHODS: We performed a comprehensive literature search across several large databases. Inclusion criteria were trials, cohorts, and large case series that analyzed the primary outcome of objective response rate by RESULTS: Data on 1770 patients from ten articles were pooled for meta-analysis, and the objective response rate to ICIs was calculated to compare DISCUSSION: In this meta-analysis evaluating the impact o

Radiation from a uniformly accelerating harmonic oscillator

We consider a radiation from a uniformly accelerating harmonic oscillator whose minimal coupling to the scalar field changes suddenly. The exact time evolutions of the quantum operators are given in terms of a classical solution of a forced harmonic oscillator. After the jumping of the coupling constant there occurs a fast absorption of energy into the oscillator, and then a slow emission follows. Here the absorbed energy is independent of the acceleration and proportional to the log of a high momentum cutoff of the field. The emitted energy depends on the acceleration and also proportional to the log of the cutoff. Especially, if the coupling is comparable to the natural frequency of the detector ($e^2/(4m) \sim \omega_0$) enormous energies are radiated away from the oscillator.Comment: 26 pages, 1 eps figure, RevTeX, minor correction in grammar, add a discussio

Physical and Emotional Pain Assessment In Outpatients Receiving Therapeutic Aphresis

Purpose: The Joint Commission has revised pain assessment standards and now requires health care entities to identify pain assessment as an organizational priority and monitor this data for hospitals, ambulatory care, and office-based procedures. However, assessments of pain in patients receiving therapeutic apheresis are currently lacking. In this prospective study, we queried our outpatients receiving therapeutic apheresis procedures to identify and characterize elements of both physical and emotional pain. Methods: In this prospective observational study, a pain assessment tool to address both physical and emotional pain was developed using elements of three validated pain assessment tools: the Wong-Baker FACES/Ten-Point Pain Rating Scale, the modified Short-Form McGill Pain Questionnaire, and the Social Emotional Distress Survey-Secondary. Every outpatient receiving therapeutic apheresis from October 1 to December 31, 2019 completed at least once per month using the 17-question pain assessment tool. Inpatients, as well as outpatients who were unable to complete the survey due to their medical condition, did not receive the pain assessment tool. Results: In total, 17 outpatients completed the pain assessment tool 42 times. All patients received therapeutic plasma exchange (TPE), and conditions treated included myasthenia gravis (14), chronic inflammatory demyelinating polyradiculoneuropathy (2), and familial hypertriglyceridemia (1). The mean Wong-Baker Scale score was 0.9 (range 0-8), indicating that patients “hurt a little bit”; of the 18 times pain was reported, most were related to vascular access issues (16/18, 89%). When asked about what elements of apheresis therapy were most distressing, concerns were reported 30 times, with the most common reported finding was also related to vascular access issues (22/30, 73%); fear of vaso-vagal reactions (3/30, 10%), fatigue (2/30, 7%), and citrate toxicities (2/30, 7%) were less common responses. Concerns about apheresis after-effects were reported 33 times, with the most common concerning after-effect being persistent fatigue of unpredictable duration (26/33, 79%). However, patients indicated that none of these concerns would affect their willingness to complete or continue apheresis therapy (0/42, 0%). The most common concerning responses regarding emotional pain included: “I have a hard time relaxing” (21/42, 50%); “I am tense and uptight” (19/42, 45%); “I am easily annoyed and sensitive” (16/42, 38%); I feel sad and down (14/42, 33%); “It is hard for me to get excited about anything” (13/42, 31%); “It is hard for me to cope and I think I will panic” (13/42, 31%); and “I am easily irritated” (12/42, 29%). Conclusion: Self-reporting of physical and emotional pain in patients receiving outpatient TPE revealed that physical pain that is experienced or feared is largely related to vascular access issues. Furthermore, many of our patients experience significant emotional pain. These data highlight additional areas in apheresis medicine in which patient care, satisfaction, and health can be improved. While this initial assessment of pain was limited to outpatients that received TPE, expansion to other procedure types and inpatients would further inform changes and improvements in our care of patients receiving apheresis procedures