Lack of detectable neoantigen depletion signals in the untreated cancer genome.

Somatic mutations can result in the formation of neoantigens, immunogenic peptides that are presented on the tumor cell surface by HLA molecules. These mutations are expected to be under negative selection pressure, but the extent of the resulting neoantigen depletion remains unclear. On the basis of HLA affinity predictions, we annotated the human genome for its translatability to HLA binding peptides and screened for reduced single nucleotide substitution rates in large genomic data sets from untreated cancers. Apparent neoantigen depletion signals become negligible when taking into consideration trinucleotide-based mutational signatures, owing to lack of power or to efficient immune evasion mechanisms that are active early during tumor evolution

Measuring the 15^{15}O(α,γ\alpha, \gamma)19^{19}Ne reaction in type I X-ray bursts using the GADGET II TPC: Software

International audience$^{15}$O($\alpha,\gamma$)$^{19}$Ne is regarded as one of the most important thermonuclear reactions in type I X-ray bursts. For studying the properties of the key resonance in this reaction using β decay, the existing Proton Detector component of the Gaseous Detector with Germanium Tagging (GADGET) assembly is being upgraded to operate as a time projection chamber (TPC) at FRIB. This upgrade includes the associated hardware as well as software and this paper mainly focusses on the software upgrade. The full detector set up is simulated using the ATTPCROOTv 2 data analysis framework for $^{20}$Mg and $^{241}$Am

Measuring the 15^{15}O(α\alpha, γ\gamma)19^{19}Ne reaction in Type I X-ray bursts using the GADGET II TPC: Hardware

International audienceSensitivity studies have shown that the 15O(α, γ)19Ne reaction is the most important reaction rate uncertainty affecting the shape of light curves from Type I X-ray bursts. This reaction is dominated by the 4.03 MeV resonance in 19Ne. Previous measurements by our group have shown that this state is populated in the decay sequence of 20Mg. A single 20Mg(βp α)15O event through the key 15O(α, γ)19Ne resonance yields a characteristic signature: the emission of a proton and alpha particle. To achieve the granularity necessary for the identification of this signature, we have upgraded the Proton Detector of the Gaseous Detector with Germanium Tagging (GADGET) into a time projection chamber to form the GADGET II detection system. GADGET II has been fully constructed, and is entering the testing phase

First application of Markov chain Monte Carlo-based Bayesian data analysis to the Doppler-shift attenuation method

Motivated primarily by the large uncertainties in the thermonuclear rate of the 30P(p,γ)31S reaction that limit our understanding of classical novae, we carried out lifetime measurements of 31S excited states using the Doppler Shift Lifetimes (DSL2) facility at the TRIUMF Isotope Separator and Accelerator (ISAC-II) facility. The 31S excited states were populated by the 3He(32S,α)31S reaction. The deexcitation γ rays were detected by a clover-type high-purity germanium detector in coincidence with the α particles detected by a silicon detector telescope. We have applied modern Markov chain Monte Carlo-based Bayesian statistical techniques to perform lineshape analyses of Doppler-shift attenuation method γ-ray data for the first time. We have determined the lifetimes of the two lowest-lying 31S excited states. First experimental upper limits on the lifetimes of four higher-lying states have been obtained. The experimental results were compared to shell-model calculations using five universal sd-shell Hamiltonians. Evidence for γ rays originating from the astrophysically important Jπ=3/2+, 260-keV 30P(p,γ)31S resonance with an excitation energy of Ex=6390.2(7) keV in 31S has also been observed, although strong constraints on the lifetime will require better statistics