Disease incidence for first-generation offspring individuals born from residents of radiation contaminated territories of Ukraine as a result of the Chernobyl accident. The observation period is 18 years from the date of birth

There was conducted an epidemiological study of the health of the first-generation offspring born by residents of radioactively contaminated territories from 1987 to 1999 years until they reached 18 years. The total cohort was 35893 individuals, among whom male offspring constituted 18138 individuals, while female offspring constituted 17755 individuals. There were created 4 groups to study offspring aged 0-3 years, depending on the time of birth of offspring after an accident with a three-year observation period. During the observation period, for the first time there were detected 21344 individuals (100%) with non-tumour diseases by certain classes of diseases ICD-10, of whom male offspring were 10,696 (49.9%), and female offspring – 10738 (50.09%). The main components in the structure of the initially detected non-tumour disease were respiratory diseases (34.45%), diseases of the endocrine system, eating disorders and metabolic disorders (16.27%), digestive organ diseases (15.58%). Together they make up 66.87%. The incidence of diseases among the FGOs of all study groups, respectively, is the following: respiratory diseases – ID by 103 man-years ± m - 59,59 ± 0,65; 25.06 ± 0.43 by 103; 24.23 ± 0.42. In the structure of diseases of the endocrine system, eating disorders and metabolic disorders (E00.0 - E90.9) total incidence of thyroid diseases (E00.0 - E07.0) – 96,6%. The incidence of respiratory disease in all study groups mainly emerged due to acute respiratory infections of the upper respiratory tract, namely: acute nasopharyngitis, sinusitis, pharyngitis, tonsillitis and other diseases in the group upper respiratory tract – chronic diseases of the tonsils and adenoids, among others acute respiratory infections of the lower respiratory tract – acute bronchitis and bronchiolitis. The pathology of the digestive system of the FGOs of all four study groups emerges through "Gastritis and duodenitis, K29-K29.9", "gallbladder and biliary diseases pathways, K80-K83.9 "and" hernias, K40-K46.9 "," diseases of the mouth, salivary glands and jaws, K00.0-K14.9". Respiratory disease rates are higher among offspring of first and second groups in (born in the period of 01.03.1987-28.02.1993) compared to the third and fourth groups (years of birth 01.03.1993-28.02.1999). The lowest levels are relevant for the fourth group. The highest incidence rates of thyroid disease are relevant for offspring of the first group compared to the other subject groups. At the same time, the incidence rates among the offspring of the second group are evidently higher than of the third and fourth groups. The lowest levels are by the fourth group. The development of thyroid disease during the 18 years of observations of each study group is characterized by the appearance of more complex nosological forms of thyroid pathology starting from 7 - 9 years. The incidence rates of digestive diseases are the highest by the first study group, the lower – by the second, and the lowest – by the fourth. The most vulnerable to the development of morbidity in the above classes of diseases among the FGOs is the life span from 7 to 15 years. This is evidenced by the increased incidence of respiratory diseases with maximum indicator at the age of 13-15 years, of thyroid diseases - at the age of 7-9 years, of digestive organs - at the age of 10-12 years

Roughness of dichotomy for the interconnected system of operator-differential equations

The paper is devoted to obtaining conditions for the roughness of dichotomy in the Banach spaces. Deep analysis of the well known papers was considered. The main results also works for the case of unbounded operators

Dynamics of open quantum systems

The coupling between the states of a system and the continuum into which it is embedded, induces correlations that are especially large in the short time scale. These correlations cannot be calculated by using a statistical or perturbational approach. They are, however, involved in an approach describing structure and reaction aspects in a unified manner. Such a model is the SMEC (shell model embedded in the continuum). Some characteristic results obtained from SMEC as well as some aspects of the correlations induced by the coupling to the continuum are discussed.Comment: 16 pages, 5 figure

PROSPECT OF USING BIOTECHNOLOGIES FOR CORRECTION OF LIVER FAILURE (Review of literature)

The review presents and discusses modern conceptions about causes of development, existing ways of prevention and correction of liver failure. Unsatisfactory effectiveness of traditional infusion and medicinal therapy, as well as low availability of extracorporal detoxification and liver transplantation methods generates a need for search of brand new patogeneticaly substantiated methods of treatment of liver failure. The data about pathogenesis of liver failure and about sanogenesis and regeneration processes are presented. Hepatocite growth factor plays leading role in that processes, most important effects of present cytokine are considered. Next part of the article describes principles, mechanism of action and results of experimental use of cell therapy method. This method has shown effectiveness in animal models and it is perspective for further improvement, but not allowed for clinical use. That's why authors consider that the most perspective solution is creation of new drug, containing regulatory peptides of liver

Resonance trapping and saturation of decay widths

Resonance trapping appears in open many-particle quantum systems at high level density when the coupling to the continuum of decay channels reaches a critical strength. Here a reorganization of the system takes place and a separation of different time scales appears. We investigate it under the influence of additional weakly coupled channels as well as by taking into account the real part of the coupling term between system and continuum. We observe a saturation of the mean width of the trapped states. Also the decay rates saturate as a function of the coupling strength. The mechanism of the saturation is studied in detail. In any case, the critical region of reorganization is enlarged. When the transmission coefficients for the different channels are different, the width distribution is broadened as compared to a chi_K^2 distribution where K is the number of channels. Resonance trapping takes place before the broad state overlaps regions beyond the extension of the spectrum of the closed system.Comment: 18 pages, 8 figures, accepted by Phys. Rev.

Dissociation energies of AgRG (RG = Ar, Kr, Xe) and AgO molecules from velocity map imaging studies

The near ultraviolet photodissociation dynamics of silver atom rare gas dimers have been studied by velocity map imaging. AgRG (RG = Ar, Kr, Xe) species generated by laser ablation are excited in the region of the C <- X continuum leading to direct, near threshold dissociation generating Ag* (2P3/2) + RG (1S0) products. Images recorded at excitation wavelengths throughout the C <- X continuum, coupled with known atomic energy levels, permit determination of the ground X (2SIGMA+) state dissociation energies of 85.9 +/- 23.4 cm-1 (AgAr), 149.3 +/- 22.4 cm-1 (AgKr) and 256.3 +/- 16.0 cm-1 (AgXe). Three additional photolysis processes, each yielding Ag atom photoproducts, are observed in the same spectral region. Two of these are markedly enhanced in intensity upon seeding the molecular beam with nitrous oxide, and are assigned to photodissociation of AgO at the two photon level. These features yield an improved ground state dissociation energy for AgO of 15965 +/- 81 cm-1, which is in good agreement with high level calculations. The third process results in Ag atom fragments whose kinetic energy shows anomalously weak photon energy dependence and is assigned tentatively to dissociative ionization of the silver dimer Ag2

Dynamics of quantum systems

A relation between the eigenvalues of an effective Hamilton operator and the poles of the $S$ matrix is derived which holds for isolated as well as for overlapping resonance states. The system may be a many-particle quantum system with two-body forces between the constituents or it may be a quantum billiard without any two-body forces. Avoided crossings of discrete states as well as of resonance states are traced back to the existence of branch points in the complex plane. Under certain conditions, these branch points appear as double poles of the $S$ matrix. They influence the dynamics of open as well as of closed quantum systems. The dynamics of the two-level system is studied in detail analytically as well as numerically.Comment: 21 pages 7 figure

Spectral Decorrelation of Nuclear Levels in the Presence of Continuum Decay

The fluctuation properties of nuclear giant resonance spectra are studied in the presence of continuum decay. The subspace of quasi-bound states is specified by one-particle one-hole and two-particle two-hole excitations and the continuum coupling is generated by a scattering ensemble. It is found that, with increasing number of open channels, the real parts of the complex eigenvalues quickly decorrelate. This appears to be related to the transition from power-law to exponential time behavior of the survival probability of an initially non-stationary state.Comment: 10 Pages, REVTEX, 4 PostScript figure

Effect of lipid parameters on fetal growth in type 2 diabetes mellitus and gestational diabetes mellitus pregnancies

Background: During pregnancy,complex changes occur in lipid profiles. The aim of the study was to evaluate the effect of lipid parameters on fetal growth in type 2 diabetes mellitus (D.M) and gestational diabetes mellitus (GDM) pregnancies. Material and methods: In forty three type 2D.M. and two hundred GDM women pregnancies were analyzed: age, body mass index (BMI), lipid parameters, HbA1c in first, second and third trimester of pregnancy, preeclampsia, and baby birth weight. Results: D.M. tip 2 and GDM group were statistically significant different in the following variables: total lipids, triglycerides, total cholesterol, BMI, age, baby birth weight, and incidence of SGA (9.4±2,3 vs. 11,0±2,3mmol/L, 2,4±1,4 vs. 3,4±1,6mmol/L, 5,5±1,2 vs. 6,4±1,4mmol/L, 30,6±5,4 vs. 26,9±5,2 kg/m2, 34±7,8 vs. 31,5±5,6 years, 3183±972 vs. 3533±699 g., 20% vs. 7,5%, respectively, p<0,05). Statistically significant correlations were found between triglycerides and HbA1c (r=0,18, p<0,05), HDL-C and HbA1c (r=-0,19, p<0,05), HDL-C and large for gestational age (LGA) (r=-0,17, p<0,05), small for gestational age (SGA) and Hba1c (r=0,29, p<0,05). LinearmultipleregressionanalysisdemonstratedthatLDL-C,triglycerides, and total cholesterol were independent predictors of LGA (p<0,05). Conclusion:LDL-C and triglycerides are predictors for macrosomia in type 2 D.M and GDM pregnancies.Thus, with good regulation of lipid profile we can avoid macrosomia from type 2 D.M and GDM pregnancies. Key words: lipid parameters, gestational diabetes mellitus, type 2 diabetes mellitus, macrosomia