6,939 research outputs found

    Preferential attachment in the protein network evolution

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    The Saccharomyces cerevisiae protein-protein interaction map, as well as many natural and man-made networks, shares the scale-free topology. The preferential attachment model was suggested as a generic network evolution model that yields this universal topology. However, it is not clear that the model assumptions hold for the protein interaction network. Using a cross genome comparison we show that (a) the older a protein, the better connected it is, and (b) The number of interactions a protein gains during its evolution is proportional to its connectivity. Therefore, preferential attachment governs the protein network evolution. The evolutionary mechanism leading to such preference and some implications are discussed.Comment: Minor changes per referees requests; to appear in PR

    Colloidal ionic complexes on periodic substrates: ground state configurations and pattern switching

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    We theoretically and numerically studied ordering of "colloidal ionic clusters" on periodic substrate potentials as those generated by optical trapping. Each cluster consists of three charged spherical colloids: two negatively and one positively charged. The substrate is a square or rectangular array of traps, each confining one such cluster. By varying the lattice constant from large to small, the observed clusters are first rod-like and form ferro- and antiferro-like phases, then they bend into a banana-like shape and finally condense into a percolated structure. Remarkably, in a broad parameter range between single-cluster and percolated structures, we have found stable supercomplexes composed of six colloids forming grape-like or rocket-like structures. We investigated the possibility of macroscopic pattern switching by applying external electrical fields.Comment: 14 pages, 13 figure

    A new minute Andean Pristimantis (Anura: Strabomantidae) from Venezuela

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    A new species of Pristimantis is described from the Venezuelan Andes. The new species is the smallest in its genus known in Venezuela and belongs to the Pristimantis unistrigatus Group. It differs from the rest of Venezuelan Andean congeners in body size (mean male SVL < 21.3 mm, female SVL < 26.3 mm), expanded discs on fingers and toes, absence of dorsolateral folds, and a distinctivecall consisting in 2–5 cricket-like short notes. The new species inhabits the southwestern part of the Cordillera de Mérida in Venezuela and the Venezuelan side of the Cordillera Oriental deColombia, and could be present on the Colombian portion of the cordillera as well

    Charge-Focusing Readout of Time Projection Chambers

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    Time projection chambers (TPCs) have found a wide range of applications in particle physics, nuclear physics, and homeland security. For TPCs with high-resolution readout, the readout electronics often dominate the price of the final detector. We have developed a novel method which could be used to build large-scale detectors while limiting the necessary readout area. By focusing the drift charge with static electric fields, we would allow a small area of electronics to be sensitive to particle detection for a much larger detector volume. The resulting cost reduction could be important in areas of research which demand large-scale detectors, including dark matter searches and detection of special nuclear material. We present simulations made using the software package Garfield of a focusing structure to be used with a prototype TPC with pixel readout. This design should enable significant focusing while retaining directional sensitivity to incoming particles. We also present first experimental results and compare them with simulation.Comment: 5 pages, 17 figures, Presented at IEEE Nuclear Science Symposium 201

    Lignin biomarkers as tracers of mercury sources in lakes water column

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    This study presents the role of specific terrigenous organic compounds as important vectors of mercury (Hg) transported from watersheds to lakes of the Canadian boreal forest. In order to differentiate the autochthonous from the allochthonous organic matter (OM), lignin derived biomarker signatures [Lambda, S/V, C/V, P/(V ? S), 3,5-Bd/V and (Ad/Al)v] were used. Since lignin is exclusively produced by terrigenous plants, this approach can give a non equivocal picture of the watershed inputs to the lakes. Moreover, it allows a characterization of the source of OM and its state of degradation. The water column of six lakes from the Canadian Shield was sampled monthly between June and September 2005. Lake total dissolved Hg concentrations and Lambda were positively correlated, meaning that Hg and ligneous inputs are linked (dissolved OM r2 = 0.62, p\0.0001; particulate OM r2 = 0.76, p\0.0001). Ratios of P/(V ? S) and 3,5-Bd/V from both dissolved OM and particulate OM of the water column suggest an inverse relationship between the progressive state of pedogenesis and maturation of the OM in soil before entering the lake, and the Hg concentrations in the water column. No relation was found between Hg levels in the lakes and the watershed flora composition—angiosperm versus gymnosperm or woody versus non-woody compounds. This study has significant implications for watershed management of ecosystems since limiting fresh terrestrial OM inputs should reduce Hg inputs to the aquatic systems. This is particularly the case for largescale land-use impacts, such as deforestation, agriculture and urbanization, associated to large quantities of soil OM being transferred to aquatic systems
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