Design and Management of Saltbush-Based Forage Systems to Improve Productivity and Reproductive Performance of Sheep

There is evidence that effective shelter can significantly improve lamb survival, but the majority of Australian studies have occurred in small paddocks where the ewes had no choice but to use shelter. In mixed farming systems with large open paddocks, it is unclear if ewes will choose to use shelter for lambing. Our multidisciplinary collaboration examines the use of woody shrubs as an opportunity to improve the survival of twin lambs. In a series of large experiments on commercial farms, we will evaluate the impact of different shrub planting configurations, orientations, and densities on microclimates at the sub-paddock scale. Twin-bearing ewes with GPS trackers will graze a mosaic of shelter options to identify lambing sites relative to climatic conditions at the time of lambing. Relatively palatable and unpalatable shrubs have been planted to explore trade-offs between the attraction of ewes to shelter against declining shelter value, because palatable shrubs are defoliated faster than relatively unpalatable options. A linked project is investigating the use of the same shrub systems to provide shade and antioxidants during joining when temperatures exceed the sheep thermal comfort zone for extended periods in summer. Hardy perennial shrubs such as saltbush offer an opportunity to improve profitability and climate resilience of farming systems, while improving landscape health. Multidisciplinary research is required to understand the benefits and limitations of these systems

The DEIMOS 10k spectroscopic survey catalog of the COSMOS field

We present a catalog of 10718 objects in the COSMOS field observed through multi-slit spectroscopy with the Deep Imaging Multi-Object Spectrograph (DEIMOS) on the Keck II telescope in the wavelength range ~5500-9800A. The catalog contains 6617 objects with high-quality spectra (two or more spectral features), and 1798 objects with a single spectroscopic feature confirmed by the photometric redshift. For 2024 typically faint objects we could not obtain reliable redshifts. The objects have been selected from a variety of input catalogs based on multi-wavelength observations in the field, and thus have a diverse selection function, which enables the study of the diversity in the galaxy population. The magnitude distribution of our objects is peaked at I_AB~23 and K_AB~21, with a secondary peak at K_AB~24. We sample a broad redshift distribution in the range 0<z<6, with one peak at z~1, and another one around z~4. We have identified 13 redshift spikes at z>0.65 with chance probabilities <4xE-4$, some of which are clearly related to protocluster structures of sizes >10 Mpc. An object-to-object comparison with a multitude of other spectroscopic samples in the same field shows that our DEIMOS sample is among the best in terms of fraction of spectroscopic failures and relative redshift accuracy. We have determined the fraction of spectroscopic blends to about 0.8% in our sample. This is likely a lower limit and at any rate well below the most pessimistic expectations. Interestingly, we find evidence for strong lensing of Ly-alpha background emitters within the slits of 12 of our target galaxies, increasing their apparent density by about a factor of 4.Comment: 28 pages, 11 figures and 5 tables. The full catalogue table is available on http://cosmos.astro.caltech.edu. Accepted for publication in the Astrophysical Journa

Development and characterisation of in vitro human oral mucosal equivalents derived from immortalised oral keratinocytes.

Tissue engineered oral mucosal equivalents (OME) are being increasingly used to measure toxicity, drug delivery, and to model oral diseases. Current OME are mainly comprised of normal oral keratinocytes (NOK) cultured on top of a normal oral fibroblasts (NOF)-containing matrix. However, the commercial supply of NOK is limited, restricting widespread use of these mucosal models. In addition, NOK suffer from poor longevity and donor-to-donor variability. Therefore, we constructed, characterised and tested the functionality of oral mucosal equivalents based on commercial TERT2-immortalised oral keratinocytes (FNB6) in order to produce a more readily available alternative to NOK-based OME. FNB6 OME cultured at an air-to-liquid interface for 14 days exhibited expression of differentiation markers cytokeratin 13 in the suprabasal layers and cytokeratin 14 in basal layer of the epithelium. Proliferating cells were restricted to the basal epithelium and there was immuno-positive expression of E-cadherin confirming the presence of established cell-to-cell contacts. The histology and expression of these structural markers paralleled those observed in the normal oral mucosa and NOK-based models. Upon stimulation with TNFα & IL-1, FNB6 OME displayed a similar global gene expression profile to NOK-based OME with increased expression of many common pro-inflammatory molecules such as chemokines (CXCL8), cytokines (IL-6) and adhesion molecules (ICAM-1) when analysed by gene array and qPCR. Similarly, pathway analysis showed that both FNB6 and NOK models initiated similar intracellular signalling upon stimulation. Gene expression in FNB6 OME was more consistent than NOK-based OME that suffered from donor variation in response to stimuli. Mucosal equivalents based on immortalised FNB6 cells are accessible, reproducible and will provide an alternative animal experimental system for studying mucosal drug delivery systems, host-pathogen interactions and drug-induced toxicity

The Population of High-Redshift Active Galactic Nuclei in the CHANDRA-Cosmos Survey

We present the high-redshift (3 3. Eighty-one sources are selected in the 0.5-2 keV band, fourteen are selected in the 2-10 keV and six in the 0.5-10 keV bands. We sample the high-luminosity (log L_((2-10keV)) > 44.15 erg s^(–1)) space density up to z ~ 5 and a fainter luminosity range (43.5 erg s^(–1) 3. We find that the space density of high-luminosity AGNs declines exponentially at all the redshifts, confirming the trend observed for optically selected quasars. At lower luminosity, the measured space density is not conclusive, and a larger sample of faint sources is needed. Comparisons with optical luminosity functions and black hole formation models are presented together with prospects for future surveys

Intense physical activity is associated with cognitive performance in the elderly

Numerous studies have reported positive impacts of physical activity on cognitive function. However, the majority of these studies have utilised physical activity questionnaires or surveys, thus results may have been influenced by reporting biases. Through the objective measurement of routine levels of physical activity via actigraphy, we report a significant association between intensity, but not volume, of physical activity and cognitive functioning. A cohort of 217 participants (aged 60–89 years) wore an actigraphy unit for 7 consecutive days and underwent comprehensive neuropsychological assessment. The cohort was stratified into tertiles based on physical activity intensity. Compared with individuals in the lowest tertile of physical activity intensity, those in the highest tertile scored 9%, 9%, 6% and 21% higher on the digit span, digit symbol, Rey Complex Figure Test (RCFT) copy and Rey Figure Test 30-min recall test, respectively. Statistically, participants in the highest tertile of physical activity intensity performed significantly better on the following cognitive tasks: digit symbol, RCFT copy and verbal fluency test (all P<0.05). The results indicate that intensity rather than quantity of physical activity may be more important in the association between physical activity and cognitive function

Jupiter's X-ray and EUV auroras monitored by Chandra, XXM-Newton, and Hisaki satellite

Jupiter's X-ray auroral emission in the polar cap region results from particles which have undergone strong field-aligned acceleration into the ionosphere. The origin of precipitating ions and electrons and the time variability in the X-ray emission are essential to uncover the driving mechanism for the high-energy acceleration. The magnetospheric location of the source field line where the X-ray is generated is likely affected by the solar wind variability. However, these essential characteristics are still unknown because the long-term monitoring of the X-rays and contemporaneous solar wind variability has not been carried out. In April 2014, the first long-term multiwavelength monitoring of Jupiter's X-ray and EUV auroral emissions was made by the Chandra X-ray Observatory, XMM-Newton, and Hisaki satellite. We find that the X-ray count rates are positively correlated with the solar wind velocity and insignificantly with the dynamic pressure. Based on the magnetic field mapping model, a half of the X-ray auroral region was found to be open to the interplanetary space. The other half of the X-ray auroral source region is magnetically connected with the prenoon to postdusk sector in the outermost region of the magnetosphere, where the Kelvin-Helmholtz (KH) instability, magnetopause reconnection, and quasiperiodic particle injection potentially take place. We speculate that the high-energy auroral acceleration is associated with the KH instability and/or magnetopause reconnection. This association is expected to also occur in many other space plasma environments such as Saturn and other magnetized rotators