On the stable configuration of ultra-relativistic material spheres. The solution for the extremely hot gas

During the last stage of collapse of a compact object into the horizon of events, the potential energy of its surface layer decreases to a negative value below all limits. The energy-conservation law requires an appearance of a positive-valued energy to balance the decrease. We derive the internal-state properties of the ideal gas situated in an extremely strong, ultra-relativistic gravitational field and suggest to apply our result to a compact object with the radius which is slightly larger than or equal to the Schwarzschild's gravitational radius. On the surface of the object, we find that the extreme attractivity of the gravity is accompanied with an extremely high internal, heat energy. This internal energy implies a correspondingly high pressure, the gradient of which has such a behavior that it can compete with the gravity. In a more detail, we find the equation of state in the case when the magnitude of the potential-type energy of constituting gas particles is much larger than their rest energy. This equation appears to be identical with the general-relativity condition of the equilibrium between the gravity and pressure gradient. The consequences of the identity are discussed.Comment: 12 pages (no figure, no table) Changes in 3-rd version: added an estimate of neutrino cooling and relative time-scale of the final stage of URMS collaps

The Backgrounds Data Center

The Strategic Defense Initiative Organization has created data centers for midcourse, plumes, and backgrounds phenomenologies. The Backgrounds Data Center (BDC) has been designated as the prime archive for data collected by SDIO programs. The BDC maintains a Summary Catalog that contains 'metadata,' that is, information about data, such as when the data were obtained, what the spectral range of the data is, and what region of the Earth or sky was observed. Queries to this catalog result in a listing of all data sets (from all experiments in the Summary Catalog) that satisfy the specified criteria. Thus, the user can identify different experiments that made similar observations and order them from the BDC for analysis. On-site users can use the Science Analysis Facility (SAFE for this purpose. For some programs, the BDC maintains a Program Catalog, which can classify data in as many ways as desired (rather than just by position, time, and spectral range as in the Summary Catalog). For example, data sets could be tagged with such diverse parameters as solar illumination angle, signal level, or the value of a particular spectral ratio, as long as these quantities can be read from the digital record or calculated from it by the ingest program. All unclassified catalogs and unclassified data will be remotely accessible

Relationships Between Subgingival Microbiota and GCF Biomarkers in Generalized Aggressive Periodontitis

Aim To examine relationships between subgingival biofilm composition and levels of gingival crevicular fluid (GCF) cytokines in periodontal health and generalized aggressive periodontitis (GAP). Materials and methods Periodontal parameters were measured in 25 periodontally healthy and 31 GAP subjects. Subgingival plaque and GCF samples were obtained from 14 sites from each subject. 40 subgingival taxa were quantified using checkerboard DNA-DNA hybridization and the concentrations of 8 GCF cytokines measured using Luminex. Cluster analysis was used to define sites with similar subgingival microbiotas in each clinical group. Significance of differences in clinical, microbiological and immunological parameters among clusters was determined using the Kruskal-Wallis test. Results GAP subjects had statistically significantly higher GCF levels of interleukin-1β (IL-1β) (p\u3c0.001), granulocyte-macrophage colony-stimulating factor (GM-CSF) (p\u3c0.01), and IL-1β/IL-10 ratio (p\u3c0.001) and higher proportions of Red and Orange complex species than periodontally healthy subjects. There were no statistically significant differences in the mean proportion of cytokines among clusters in the periodontally healthy subjects, while the ratio IL-1β/IL-10 (p\u3c0.05) differed significantly among clusters in the aggressive periodontitis group. Conclusions Different subgingival biofilm profiles are associated with distinct patterns of GCF cytokine expression. Aggressive periodontitis subjects were characterized by a higher IL-1β/IL-10 ratio than periodontally healthy subjects, suggesting an imbalance between pro- and anti-inflammatory cytokines in aggressive periodontitis

Rotational symmetry of self-similar solutions to the Ricci flow

Let (M,g) be a three-dimensional steady gradient Ricci soliton which is non-flat and \kappa-noncollapsed. We prove that (M,g) is isometric to the Bryant soliton up to scaling. This solves a problem mentioned in Perelman's first paper.Comment: Final version, to appear in Invent. Mat

INTEGRAL observations of five sources in the Galactic Center region

A number of new X-ray sources (IGR J17091-3624, IGR/XTE J17391-3021, IGR J17464-3213 (= XTE J17464-3213 = H 1743-322), IGR J17597-2201, SAX/IGR J18027-2017) have been observed with the INTEGRAL observatory during ultra deep exposure of the Galactic Center region in August-September 2003. Most of them were permanently visible by the INTEGRAL at energies higher than $\sim 20$ keV, but IGR/XTE J17391-3021 was observed only during its flaring activity with a flux maximum of $\sim120$ mCrab. IGR J17091-3624, IGR J17464-3213 and IGR J17597-2201 were detected up to $\sim 100$-150 keV. In this paper we present the analysis of INTEGRAL observations of these sources to determine the nature of these objects. We conclude that all of them have a galactic origin. Two sources are black hole candidates (IGR J17091-3624 and IGR J17464-3213), one is an LMXB neutron star binary (presumably an X-ray burster) and two other sources (IGR J17597-2201 and SAX/IGR J18027-2017) are neutron stars in high mass binaries; one of them (SAX/IGR J18027-2017) is an accreting X-ray pulsar.Comment: 8 pages, 7 figures, 2 tables, accepted for publication in A&

Анализ развития систем впрыска топлива дизельных двигателей легковых автомобилей

The given paper considers dynamics of the development of diesel engine fuel injection systems. The scheme of up-to-date electronic control system of a high pressure fuel pump is presented in the paper. The interaction of input and output parameters of diesel engine fuel system and a number of requirements to diesel engine fuel system are analyzed in the paper.Рассматривается динамика развития систем впрыска топлива дизельных двигателей. Приводится схема современного электронного управления топливного насоса высокого давления. Анализируются взаимодействие входных и выходных параметров системы питания дизельного двигателя, комплекс требований к системе питания дизельного двигателя

Bohm and Einstein-Sasaki Metrics, Black Holes and Cosmological Event Horizons

We study physical applications of the Bohm metrics, which are infinite sequences of inhomogeneous Einstein metrics on spheres and products of spheres of dimension 5 <= d <= 9. We prove that all the Bohm metrics on S^3 x S^2 and S^3 x S^3 have negative eigenvalue modes of the Lichnerowicz operator and by numerical methods we establish that Bohm metrics on S^5 have negative eigenvalues too. We argue that all the Bohm metrics will have negative modes. These results imply that higher-dimensional black-hole spacetimes where the Bohm metric replaces the usual round sphere metric are classically unstable. We also show that the stability criterion for Freund-Rubin solutions is the same as for black-hole stability, and hence such solutions using Bohm metrics will also be unstable. We consider possible endpoints of the instabilities, and show that all Einstein-Sasaki manifolds give stable solutions. We show how Wick rotation of Bohm metrics gives spacetimes that provide counterexamples to a strict form of the Cosmic Baldness conjecture, but they are still consistent with the intuition behind the cosmic No-Hair conjectures. We show how the Lorentzian metrics may be created ``from nothing'' in a no-boundary setting. We argue that Lorentzian Bohm metrics are unstable to decay to de Sitter spacetime. We also argue that noncompact versions of the Bohm metrics have infinitely many negative Lichernowicz modes, and we conjecture a general relation between Lichnerowicz eigenvalues and non-uniqueness of the Dirichlet problem for Einstein's equations.Comment: 53 pages, 11 figure

The study of the negative pion production in neutron-proton collisions at beam momenta below 1.8 GeV/c

A detailed investigation of the reaction np -> pp\pi^{-} has been carried out using the data obtained with the continuous neutron beam produced by charge exchange scattering of protons off a deuterium target. A partial wave event-by-event based maximum likelihood analysis was applied to determine contributions of different partial waves to the pion production process. The combined analysis of the np -> pp\pi^{-} and pp -> pp\pi^{0} data measured in the same energy region allows us to determine the contribution of isoscalar partial waves (I=0) in the momentum range from 1.1 up to 1.8 GeV/c. The decay of isoscalar partial waves into (^1S_0)_{pp}\pi$ channel provides a good tool for a determination of the pp S-wave scalar scattering length in the final state which was found to be a_{pp}=-7.5\pm 0.3 fm.Comment: 6 pages, 6 figure

Discrete molecular dynamics simulations of peptide aggregation

We study the aggregation of peptides using the discrete molecular dynamics simulations. At temperatures above the alpha-helix melting temperature of a single peptide, the model peptides aggregate into a multi-layer parallel beta-sheet structure. This structure has an inter-strand distance of 0.48 nm and an inter-sheet distance of 1.0 nm, which agree with experimental observations. In this model, the hydrogen bond interactions give rise to the inter-strand spacing in beta-sheets, while the Go interactions among side chains make beta-strands parallel to each other and allow beta-sheets to pack into layers. The aggregates also contain free edges which may allow for further aggregation of model peptides to form elongated fibrils.Comment: 15 pages, 8 figure

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy.

Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications. In advanced cancer, disease burden and cfDNA tumor content are often elevated, yielding unique precision oncology opportunities. We sought to demonstrate the utility of a pan-cancer, rapid, inexpensive, whole genome NGS of cfDNA approach (PRINCe) as a precision oncology screening strategy via ultra-low coverage (~0.01x) tumor content determination through genome-wide copy number alteration (CNA) profiling. We applied PRINCe to a retrospective cohort of 124 cfDNA samples from 100 patients with advanced cancers, including 76 men with metastatic castration-resistant prostate cancer (mCRPC), enabling cfDNA tumor content approximation and actionable focal CNA detection, while facilitating concordance analyses between cfDNA and tissue-based NGS profiles and assessment of cfDNA alteration associations with mCRPC treatment outcomes. Therapeutically relevant focal CNAs were present in 42 (34%) cfDNA samples, including 36 of 93 (39%) mCRPC patient samples harboring AR amplification. PRINCe identified pre-treatment cfDNA CNA profiles facilitating disease monitoring. Combining PRINCe with routine targeted NGS of cfDNA enabled mutation and CNA assessment with coverages tuned to cfDNA tumor content. In mCRPC, genome-wide PRINCe cfDNA and matched tissue CNA profiles showed high concordance (median Pearson correlation = 0.87), and PRINCe detectable AR amplifications predicted reduced time on therapy, independent of therapy type (Kaplan-Meier log-rank test, chi-square = 24.9, p &lt; 0.0001). Our screening approach enables robust, broadly applicable cfDNA-based precision oncology for patients with advanced cancer through scalable identification of therapeutically relevant CNAs and pre-/post-treatment genomic profiles, enabling cfDNA- or tissue-based precision oncology workflow optimization