Gravitation on a Homogeneous Domain

Among all plastic deformations of the gravitational Lorentz vacuum \cite{wr1} a particular role is being played by conformal deformations. These are conveniently described by using the homogeneous space for the conformal group SU(2,2)/S(U(2)x U(2)) and its Shilov boundary - the compactified Minkowski space \tilde{M} [1]. In this paper we review the geometrical structure involved in such a description. In particular we demonstrate that coherent states on the homogeneous Kae}hler domain give rise to Einstein-like plastic conformal deformations when extended to \tilde{M} [2].Comment: 10 pages, 1 figure; four misprints in the original version corrected: one lacking closing parenthesis, two letters, and an overall sign in front of the primitive function on p.

Cyber-physical systems design for runtime trustworthiness maintenance supported by tools

The trustworthiness of cyber-physical systems is a critical factor for establishing wide-spread adoption of these systems. Hence, especially the behavior of safety-critical software components needs to be monitored and managed during system operation. Runtime trustworthiness maintenance should be planned and prepared in early requirements and design phases. This involves the identification of threats that may occur and affect user’s trust at runtime, as well as related controls that can be executed to mitigate the threats. Furthermore, observable and measureable system quality properties have to be identified as indicators of threats, and interfaces for reporting these properties as well as for executing controls have to be designed and implemented. This paper presents a process model for preparing and designing systems for runtime trustworthiness maintenance, which is supported by several tools that facilitate the tasks to be performed by requirements engineers and system designer

A tool for monitoring and maintaining system trustworthiness at runtime

Trustworthiness of software systems is a key factor in their acceptance and effectiveness. This is especially the case for cyber-physical systems, where incorrect or even sub-optimal functioning of the system may have detrimental effects. In addition to designing systems with trustworthiness in mind, monitoring and maintaining trustworthiness at runtime is critical to identify issues that could negatively affect a system's trustworthiness. In this paper, we present a fully operational tool for system trustworthiness maintenance, covering a comprehensive set of quality attributes. It automatically detects, and in some cases mitigates, trustworthiness threatening events. The use of such a tool can enable complex software systems to support runtime adaptation and self-healing, thus reducing the overall upkeep cost and complexity

A transient formulation of Newton’s cooling law for spherical bodies

Newton's law of cooling is shown to underestimate the heat flux between a spherical body (droplet) and a homogeneous gas after this body is suddenly immersed into the gas. This problem is rectified by replacing the gas thermal conductivity by the effective thermal conductivity. The latter reduces to the gas thermal conductivity in the limit of t→ϱ, but can be substantially higher in the limit of t→0. In the case of fuel droplet heating in a medium duty truck Diesel engine the gas thermal conductivity may need to be increased by more than 100 percent at the initial stage of calculations to account for transient effects during the process of droplet heating

Low-cost workbench client / server cores for remote experiments in electronics

This paper offers an open-source solution to implement low-cost workbenches serving a wide range of remote experiments in electronics. The proposed solution comprises 1) a small (9,65 x 6,1 cm) Linux server board; 2) a server core supporting two TCP/IP communication channels, and general purpose I/O pin drivers to interface the remote experiment hardware; and 3) a client core based on a multi-tab user interface supporting text file management to exchange experiment scripts / status information, and a mini-browser for webcasting in distance learning scenarios, live image feedback from IP cameras located in the remote workbench, etc. Additional drivers and application-specific tabs can be added to the server / client cores, to suit the requirements of each application. Two remote workbenches for microcontroller and digital systems testing courses were developed, and are also presented in this document

Finding Homogeneity in Heterogeneity—A New Approach to Quantifying Landscape Mosaics Developed for the Lao PDR

A key challenge for land change science in general and research on swidden agriculture in particular, is linking land cover information to human–environment interactions over larger spatial areas. In Lao PDR, a country facing rapid and multi-level land change processes, this hinders informed policy- and decision-making. Crucial information on land use types and people involved is still lacking. This article proposes an alternative approach for the description of landscape mosaics. Instead of analyzing local land use combinations, we studied land cover mosaics at a meso-level of spatial scale and interpreted these in terms of human–environmental interactions. These landscape mosaics were then overlaid with population census data. Results showed that swidden agricultural landscapes, involving 17% of the population, dominate 29% of the country, while permanent agricultural landscapes involve 74% of the population in 29% of the territory. Forests still form an important component of these landscape mosaics

Secondary education reform in Lesotho and Zimbabwe and the needs of rural girls: Pronouncements, policy and practice

Analysis of the educational needs of rural girls in Lesotho and Zimbabwe suggests a number of shortcomings in the current form of secondary education, and ways in which it might be modified so as to serve this sizeable group of students better. Several of the shortcomings, notably in relation to curricular irrelevance and excessive focus on examinations, have long been recognised, including by politicians. Yet political pronouncements are seldom translated into policy, and even where policy is formulated, reforms are seldom implemented in schools. This paper makes use of interviews with educational decision-makers in the two southern African countries and a range of documentary sources to explore why, despite the considerable differences between the two contexts, much needed educational reforms have been implemented in neither

CRISPR medicine for blood disorders: Progress and challenges in delivery

Blood disorders are a group of diseases including hematological neoplasms, clotting disorders and orphan immune deficiency diseases that affects human health. Current improvements in genome editing based therapeutics demonstrated preclinical and clinical proof to treat different blood disorders. Genome editing components such as Cas nucleases, guide RNAs and base editors are supplied in the form of either a plasmid, an mRNA, or a ribonucleoprotein complex. The most common delivery vehicles for such components include viral vectors (e.g., AAVs and RV), non-viral vectors (e.g., LNPs and polymers) and physical delivery methods (e.g., electroporation and microinjection). Each of the delivery vehicles specified above has its own advantages and disadvantages and the development of a safe transferring method for ex vivo and in vivo application of genome editing components is still a big challenge. Moreover, the delivery of genome editing payload to the target blood cells possess key challenges to provide a possible cure for patients with inherited monogenic blood diseases and hematological neoplastic tumors. Here, we critically review and summarize the progress and challenges related to the delivery of genome editing elements to relevant blood cells in an ex vivo or in vivo setting. In addition, we have attempted to provide a future clinical perspective of genome editing to treat blood disorders with possible clinical grade improvements in delivery methods