Evaluation of alternative solvents in common amide coupling reactions : replacement of dichloromethane and N,N-dimethylformamide

A range of alternative solvents have been evaluated within amidation reactions employing common coupling reagents with a view to identifying suitable replacements for dichloromethane and N,N-dimethylformamid

Proposed low-energy absolute calibration of nuclear recoils in a dual-phase noble element TPC using D-D neutron scattering kinematics

We propose a new technique for the calibration of nuclear recoils in large noble element dual-phase time projection chambers used to search for WIMP dark matter in the local galactic halo. This technique provides an $\textit{in situ}$ measurement of the low-energy nuclear recoil response of the target media using the measured scattering angle between multiple neutron interactions within the detector volume. The low-energy reach and reduced systematics of this calibration have particular significance for the low-mass WIMP sensitivity of several leading dark matter experiments. Multiple strategies for improving this calibration technique are discussed, including the creation of a new type of quasi-monoenergetic 272 keV neutron source. We report results from a time-of-flight based measurement of the neutron energy spectrum produced by an Adelphi Technology, Inc. DD108 neutron generator, confirming its suitability for the proposed nuclear recoil calibration.Peer Reviewe

Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches

Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury. Their diverse biological activities are derived from an ability to regulate a remarkable number of proteins. However, few methods exist for the rapid identification of glycosaminoglycan–protein interactions and for studying the potential of glycosaminoglycans to assemble multimeric protein complexes. Here, we report a multidisciplinary approach that combines new carbohydrate microarray and computational modeling methodologies to elucidate glycosaminoglycan–protein interactions. The approach was validated through the study of known protein partners for heparan and chondroitin sulfate, including fibroblast growth factor 2 (FGF2) and its receptor FGFR1, the malarial protein VAR2CSA, and tumor necrosis factor-α (TNF-α). We also applied the approach to identify previously undescribed interactions between a specific sulfated epitope on chondroitin sulfate, CS-E, and the neurotrophins, a critical family of growth factors involved in the development, maintenance, and survival of the vertebrate nervous system. Our studies show for the first time that CS is capable of assembling multimeric signaling complexes and modulating neurotrophin signaling pathways. In addition, we identify a contiguous CS-E-binding site by computational modeling that suggests a potential mechanism to explain how CS may promote neurotrophin-tyrosine receptor kinase (Trk) complex formation and neurotrophin signaling. Together, our combined microarray and computational modeling methodologies provide a general, facile means to identify new glycosaminoglycan–protein–protein interactions, as well as a molecular-level understanding of those complexes

Enhancement flame flashback resistance against CIVB and BLF in swirl burners

Swirl combustors have proven as effective flame stabilisers over a wide range of operation conditions thanks to the formation of well-known swirl coherent structures. However, employment of swirl combustors to work on lean premixed combustion modes while introducing alternative fuels such as high hydrogen blends result in many combustion instabilities. Under these conditions, flame flashback has been considered as one of the major instability problems that have the potential of causing considerable damages of the combustion systems hardware in addition to the significant increase in pollutant levels. Combustion Induced Vortex Breakdown (CIVB) is considered a very particular mode of flashback mechanism in swirling flows as this type of flashback occurs even when the fresh mixture’s velocity is higher than the flame speed, consequence of the interaction between swirl structures and swirl burner geometries. Improvements of burner geometries and manipulation of swirl flows can produce good resistance against this type of flashback. However, increase flame flashback resistance against CIVB can lead to an increase in the propensity of another flashback mechanism, Boundary Layer Flashback (BLF). Thus this paper presents an experimental and numerical approach that allows the increase in CIVB resistance by using diffusive air injection and simultaneously avoid BLF by changing the wall boundary layer characteristics using microsurface grids as a liner for the nozzle wall. Results show that using those two techniques together has promising potentials regarding wider stable operation for swirl combustors, enabling them to burn a great variety of fuel blends safely

Status of the LUX Dark Matter Search

The Large Underground Xenon (LUX) dark matter search experiment is currently being deployed at the Homestake Laboratory in South Dakota. We will highlight the main elements of design which make the experiment a very strong competitor in the field of direct detection, as well as an easily scalable concept. We will also present its potential reach for supersymmetric dark matter detection, within various timeframes ranging from 1 year to 5 years or more.Comment: 4 pages, in proceedings of the SUSY09 conferenc