Competition increases binding errors in visual working memory

When faced with maintaining multiple objects in visual working memory, item information must be bound to the correct object in order to be correctly recalled. Sometimes, however, binding errors occur, and participants report the feature (e.g., color) of an unprobed, non-target item. In the present study, we examine whether the configuration of sample stimuli affects the proportion of these binding errors. The results demonstrate that participants mistakenly report the identity of the unprobed item (i.e., they make a non-target response) when sample items are presented close together in space, suggesting that binding errors can increase independent of increases in memory load. Moreover, the proportion of these non-target responses is linearly related to the distance between sample items, suggesting that these errors are spatially specific. Finally, presenting sample items sequentially decreases non-target responses, suggesting that reducing competition between sample stimuli reduces the number of binding errors. Importantly, these effects all occurred without increases in the amount of error in the memory representation. These results suggest that competition during encoding can account for some of the binding errors made during VWM recall

1.6 GHz Low-Power Cross-Correlator System Enabling Geostationary Earth Orbit Aperture Synthesis

We present a 64-channel cross-correlator system for space-borne synthetic aperture imaging. Two different types of ASICs were developed to fit into this system: An 8-channel comparator ASIC implemented in a 130 nm SiGe BiCMOS process technology performs A/D conversion, while a single 64-channel digital cross-correlator ASIC implemented in a 65 nm CMOS process performs the signal processing. The digital ASIC handles 2016 cross-correlations at up to 3.6 GS/s and has a power dissipation of only 0.13 mW/correlation/GHz at a supply voltage of 1 V. The comparator ASIC can handle sample rates of at least 4.5 GS/s with a power dissipation of 47 mW/channel or 1 GS/s with a power dissipation of 17 mW/channel. The assembled system consists of a single board measuring a mere 136 x 136 mm(2) and weighing only 135 g. The assembled system demonstrates crosstalk of 0.04% between neighboring channels and stability of 800 s. We provide ASIC and system-board measurement results that demonstrate that aperture synthesis can be a viable approach for Earth observation from a geostationary Earth orbit

More-Space – A Simulation Tool for University Room Management

As proposed in various studies, educational facilities hold a high potential yield for improvement of room utilization. The goal of the project “MoreSpace” at Vienna University of Technology (TU Vienna) was to develop a hybrid modeling approach which helps to increase the efficiency of the university’s space utilization. Besides coupling of Discrete Event Simulation (DEVS), Agent-based (AB) methods and Cellular Automata (CA), successful deployment of such a model requires a thorough integration within the peripheral system. Which in turn leads to preconditions that have to be met, (e.g. by input - data, visualization of results, dissemination, etc.). This paper covers the methods applied for analyses of the model and the peripheral system, which enable model integration. For this is necessary to also focus on the psycho-social layer of the institution, as it is this layer that often leads to rejection of otherwise “good” solutions by the people within institutions. The paper further describes a deployment matrix which puts the simulations - models mode of operation (i.e. one time utilization for consulting, recurrent and frequent utilization) into context with met preconditions and the required depth of system integration. This allows it to estimate whether a model can be deployed as intended or not; with alternatives being either a transformation of the system, reformulation of the question(s) towards the model or - in the worst case - abortion of the deployment process. In the latter case the value of the deployment matrix lies within an early judgment of the situation saving resources that would have been spend otherwise. In addition it is possible to use these for developing alternative solutions in support of the intentional goals

The SKA Particle Array Prototype: The First Particle Detector at the Murchison Radio-astronomy Observatory

We report on the design, deployment, and first results from a scintillation detector deployed at the Murchison Radio-astronomy Observatory (MRO). The detector is a prototype for a larger array -- the Square Kilometre Array Particle Array (SKAPA) -- planned to allow the radio-detection of cosmic rays with the Murchison Widefield Array and the low-frequency component of the Square Kilometre Array. The prototype design has been driven by stringent limits on radio emissions at the MRO, and to ensure survivability in a desert environment. Using data taken from Nov.\ 2018 to Feb.\ 2019, we characterize the detector response while accounting for the effects of temperature fluctuations, and calibrate the sensitivity of the prototype detector to through-going muons. This verifies the feasibility of cosmic ray detection at the MRO. We then estimate the required parameters of a planned array of eight such detectors to be used to trigger radio observations by the Murchison Widefield Array.Comment: 17 pages, 14 figures, 3 table

Uncertain voronoi cell computation based on space decomposition

LNCS v. 9239 entitled: Advances in Spatial and Temporal Databases: 14th International Symposium, SSTD 2015 ... ProceedingsThe problem of computing Voronoi cells for spatial objects whose locations are not certain has been recently studied. In this work, we propose a new approach to compute Voronoi cells for the case of objects having rectangular uncertainty regions. Since exact computation of Voronoi cells is hard, we propose an approximate solution. The main idea of this solution is to apply hierarchical access methods for both data and object space. Our space index is used to efficiently find spatial regions which must (not) be inside a Voronoi cell. Our object index is used to efficiently identify Delauny relations, i.e., data objects which affect the shape of a Voronoi cell. We develop three algorithms to explore index structures and show that the approach that descends both index structures in parallel yields fast query processing times. Our experiments show that we are able to approximate uncertain Voronoi cells much more effectively than the state-of-the-art, and at the same time, improve run-time performance.postprin

Markers of cholesterol synthesis to cholesterol absorption across the spectrum of non-dialysis CKD: An observational study

In dialysis patients, cholesterol-lowering therapy with statins is less effective than in other high-risk patients. This may be explained by a shift from cholesterol synthesis toward cholesterol absorption. In line, markers of cholesterol absorption-such as campesterol-better predict atherosclerotic cardiovascular events than markers of cholesterol synthesis-such as lathosterol-in dialysis patients. To test the association between markers of cholesterol absorption such as campesterol-and markers of cholesterol synthesis-such as lathosterol-against cardiovascular events in non-dialysis CKD patients. Altogether 251 patients those not on lipid-lowering agents were followed annually for the composite endpoint atherosclerotic cardiovascular disease (ASCVD) and all-cause death. During follow-up of 5.2 ± 2.1 years, 61 participants reached the primary endpoint atherosclerotic cardiovascular disease/all-cause death [ASCVD/D], 47 participants suffered from ASCVD, and 46 participants died. In univariate Cox regression analysis, campesterol/lathosterol ratio did not significantly predict ASCVD/D (HR 0.643; 0.358-1.155; 3rd vs. 1st tertile), all-cause death (HR 1.309; 0.604-2.838; 3rd vs. 1st tertile) nor ASCVD (HR 0.589; 0.311-1.118; 3rd vs. 1st tertile). We did not observe a shift from cholesterol synthesis to cholesterol absorption across the spectrum of non-dialysis CKD. Campesterol/lathosterol ratio did not predict future ASCVD or all-cause death in non-dialysis CKD

Assessment of Local Reaction to Vaccines in Live Piglets with Magnetic Resonance Imaging Compared to Histopathology

The safety of veterinary vaccines is assessed in clinical trials in Europe. The assessment of the local tissue reaction to vaccination by magnetic resonance imaging (MRI) could reduce the number of animals needed because repeated examinations can be performed in the same animal over time. The present study compared the evaluation of local tissue reactions to vaccination using MRI in live pigs with histopathology of porcine tissue, the current gold standard in regulatory safety testing. Eight piglets each were administered one of two commercial vaccines into marked injection sites. All animals were sedated and scanned repeatedly by MRI using a contrast agent up to day 29 after vaccination. On day 29, the animals were euthanized and underwent a pathological examination. The MRI results were compared with the pathomorphological findings at the injection site by regression analysis. The MR images and the pathological examinations yielded matching results concerning the sizes of the affected tissue volumes or areas. The use of MRI for regulatory safety testing can reduce the number of animals needed to 8 per examination group. The volume of a local reaction and its progression over time can be evaluated and documented. If persistent lesions develop a final pathomorphological examination is needed to identify the kind and local distribution of the reaction

Plasma biomarkers outperform echocardiographic measurements for cardiovascular risk prediction in kidney transplant recipients: results of the HOME ALONE study

Background Since kidney transplant recipients (KTRs) have a high cardiovascular disease burden, adequate risk prediction is of importance. Whether echocardiographic parameters and plasma biomarkers, natriuretic peptides [N-terminal pro-B-type natriuretic peptide (NT-proBNP)] and troponin T provide complementary or overlapping prognostic information on cardiovascular events remains uncertain. Methods The prospective Heterogeneity of Monocytes and Echocardiography Among Allograft Recipients in Nephrology (HOME ALONE) study followed 177 KTRs for 5.4 ± 1.7 years. Predefined endpoints were hospitalization for acute decompensated heart failure or all-cause death (HF/D) and major atherosclerotic cardiovascular events or all-cause death (MACE/D). At baseline, plasma NT-proBNP, plasma troponin T and echocardiographic parameters [left atrial volume index, left ventricular (LV) mass index, LV ejection fraction, and LV filling pressure] were assessed. Results Among all echocardiographic and plasma biomarkers measured, only NT-proBNP was consistently associated with HF/D in univariate and multivariate {third versus first tertile: hazard ratio [HR] 4.20 [95% confidence interval (CI) 1.02–17.27]} analysis, and only troponin T was consistently associated with MACE/D in univariate and multivariate [third versus first tertile: HR 8.15 (95% CI 2.75–24.18)] analysis. Conclusion Our data suggest that plasma biomarkers are robust and independent predictors of heart failure and atherosclerotic cardiovascular events after kidney transplantation, whereas standard echocardiographic follow-up does not add to risk prediction

Nuclear Cryogenic Propulsion Stage

The fundamental capability of Nuclear Thermal Propulsion (NTP) is game changing for space exploration. A first generation Nuclear Cryogenic Propulsion Stage (NCPS) based on NTP could provide high thrust at a specific impulse above 900 s, roughly double that of state of the art chemical engines. Characteristics of fission and NTP indicate that useful first generation systems will provide a foundation for future systems with extremely high performance. The role of the NCPS in the development of advanced nuclear propulsion systems could be analogous to the role of the DC-3 in the development of advanced aviation. Progress made under the NCPS project could help enable both advanced NTP and advanced NEP