220 research outputs found

    Синтез и свойства реагентов на основе иодзамещенных гидроксиполиэтил бензоатов

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    Поиск новых органических производных иода и изучение препаративных возможностей данных соединений в окислительных процессах позволит ввести в практику органического синтеза новые реагенты для окисления. В результате работы получены новые соединения - иодзамещенные гидроксиполиэтил бензоаты. При окислении данных соединений будут получены водорастворимые соединения поливалентного иода, которые в свою очередь должны проявить свойства мягких окислителей в окислительных превращениях спиртов. Таким образом, становится актуальным синтез и изучение препаративных возможностей легко извлекаемых реагентов с требуемой окислительной активностью.The search for new organic derivatives of iodine and the study of the preparative capabilities of these compounds in oxidative processes will make it possible to introduce new reagents for oxidation into the practice of organic synthesis. As a result of the work, new compounds — iodosubstituted hydroxypolyethyl benzoates — were obtained. During the oxidation of these compounds, water-soluble compounds of polyvalent iodine will be obtained, which in turn should exhibit the properties of soft oxidizing agents in the oxidative transformations of alcohols. Thus, the synthesis and study of the preparative capabilities of easily recoverable reagents with the required oxidative activity becomes relevant

    Reliable and randomized data distribution strategies for large scale storage systems

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    The ever-growing amount of data requires highly scalable storage solutions. The most flexible approach is to use storage pools that can be expanded and scaled down by adding or removing storage devices. To make this approach usable, it is necessary to provide a solution to locate data items in such a dynamic environment. This paper presents and evaluates the Random Slicing strategy, which incorporates lessons learned from table-based, rule-based, and pseudo-randomized hashing strategies and is able to provide a simple and efficient strategy that scales up to handle exascale data. Random Slicing keeps a small table with information about previous storage system insert and remove operations, drastically reducing the required amount of randomness while delivering a perfect load distribution.Peer ReviewedPostprint (author’s final draft

    Оценка прочностных характеристик зарубежного и отечественного центраторов

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    В статье представлен сравнительный анализ двух исполнений центраторов-турбулизаторов разных производителей путем оценивания напряженно-деформированного состояния проектных моделей центраторов фирм "Matrix" и "Механический завод" при эксплуатационных нагрузках

    FDG PET-CT demonstration of metastatic neuroendocrine tumor of prostate

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    which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background: FDG PET-CT is generally not suitable for diagnosing prostate cancer because of low glycolysis of the tumor cells. Neuroendocrine differentiation of the prostate cancer is often associated with early visceral metastasis and dismal prognosis, which is resulted from changed metabolic and regulatory pathways. Case presentation: A case is reported in this paper that FDG PET-CT demonstrates intense uptake of neuroendocrine tumor of the prostate and multiple metastases. Conclusion: There is high glycolysis and strong FDG-avidity of neuroendocrine tumor of the prostate, which is similar to that of high grade of neuroendocrine tumor in other tissue and organs. In some selected cases of prostate neuroendocrine cancer, whole body FDG PET-CT may be helpful for detection of metastatic disease. Background Positron emission tomography (PET) is a new imaging modality which has been widely used for detection o

    Proline-rich antimicrobial peptide, PR-39 gene transduction altered invasive activity and actin structure in human hepatocellular carcinoma cells

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    PR-39 is an endogenous proline-rich antimicrobial peptide which induces the synthesis of syndecan-1, a transmembrane heparan sulphate proteoglycan involved in cell-to-matrix interactions and wound healing. Previously, we revealed that the expression of syndecan-1 was reduced in human hepatocellular carcinomas with high metastatic potential and speculated that syndecan-1 played an important role in inhibition of invasion and metastasis. It is assumed that a modification of this process with PR-39 and syndecan-1 may result in a new strategy by which it can inhibit the invasion and metastasis. Therefore, we transduced a gene of PR-39 into human hepatocellular carcinoma cell line HLF, which shows a low expression of syndecan-1 and a high in vitro invasive activity, and examined whether this procedure could reduce the invasive activity of tumour cells. In two transfectants with PR-39 gene, the syndecan-1 expression was induced and the invasive activity in type I collagen-coated chamber was inhibited. Moreover, these transfectants showed the suppression of motile activity assayed by phagokinetic tracks in addition to the disorganization of actin filaments observed by a confocal imaging system. In contrast, five transfectants with syndecan-1 gene in the HLF cells revealed suppression of invasive activity but did not alter the motile activity and actin structures of the cell. These results suggest that PR-39 has functions involved in the suppression of motile activity and alteration of actin structure on human hepatocellular carcinoma cells in addition to the suppression of invasive activity which might result from the induction of syndecan-1 expression. © 1999 Cancer Research Campaig

    Gastrin-releasing peptide receptor-based targeting using bombesin analogues is superior to metabolism-based targeting using choline for in vivo imaging of human prostate cancer xenografts

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    Purpose: Prostate cancer (PC) is a major health problem. Overexpression of the gastrin-releasing peptide receptor (GRPR) in PC, but not in the hyperplastic prostate, provides a promising target for staging and monitoring of PC. Based on the assumption that cancer cells have increased metabolic activity, metabolism-based tracers are also being used for PC imaging. We compared GRPR-based targeting using the68Ga-labelled bombesin analogue AMBA with metabolism-based tar

    The Open Innovation in Science research field: a collaborative conceptualisation approach

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    Openness and collaboration in scientific research are attracting increasing attention from scholars and practitioners alike. However, a common understanding of these phenomena is hindered by disciplinary boundaries and disconnected research streams. We link dispersed knowledge on Open Innovation, Open Science, and related concepts such as Responsible Research and Innovation by proposing a unifying Open Innovation in Science (OIS) Research Framework. This framework captures the antecedents, contingencies, and consequences of open and collaborative practices along the entire process of generating and disseminating scientific insights and translating them into innovation. Moreover, it elucidates individual-, team-, organisation-, field-, and society‐level factors shaping OIS practices. To conceptualise the framework, we employed a collaborative approach involving 47 scholars from multiple disciplines, highlighting both tensions and commonalities between existing approaches. The OIS Research Framework thus serves as a basis for future research, informs policy discussions, and provides guidance to scientists and practitioners
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