Asymptotics in Deconvolution Models: Approximating Perfect Knowledge

Groeneboom, P. [Promotor]Jongbloed, G. [Promotor

Gap and opportunity analysis of hydrological monitoring in the Ziway-Shala Sub-basin, Ethiopia

This working paper was prepared under a development and conservation project – Societal Development and Ecosystems Conservation in Sahelian Wetlands (SAWEL) – focusing on improving food security and nutrition in the Sahel region by helping to safeguard wetlands through ecologically sustainable agricultural water management. SAWEL is supported by the Swiss Agency for Development and Cooperation (SDC). This paper provides an overview of the current situation with regards to hydrological monitoring in the Ziway-Shala sub-basin in the Central Rift Valley of Ethiopia, including details of existing river and lake gauging stations in the sub-basin. The study was jointly conducted by the International Water Management Institute (IWMI) and Hydrosolutions through consultation with staff of the Rift Valley Lakes Basin Development Office (RVLBDO), field trips to gauging stations, inspection of data recording books and reviewing previous studies. In addition to highlighting gaps in hydrological monitoring in the Ziway-Shala sub-basin, opportunities (e.g., remote sensing and citizen science) for novel, non-traditional hydrological monitoring are also presented

In praise of arrays

Microarray technologies have both fascinated and frustrated the transplant community since their introduction roughly a decade ago. Fascination arose from the possibility offered by the technology to gain a profound insight into the cellular response to immunogenic injury and the potential that this genomic signature would be indicative of the biological mechanism by which that stress was induced. Frustrations have arisen primarily from technical factors such as data variance, the requirement for the application of advanced statistical and mathematical analyses, and difficulties associated with actually recognizing signature gene-expression patterns and discerning mechanisms. To aid the understanding of this powerful tool, its versatility, and how it is dramatically changing the molecular approach to biomedical and clinical research, this teaching review describes the technology and its applications, as well as the limitations and evolution of microarrays, in the field of organ transplantation. Finally, it calls upon the attention of the transplant community to integrate into multidisciplinary teams, to take advantage of this technology and its expanding applications in unraveling the complex injury circuits that currently limit transplant survival

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

Crohn's disease (CD) is a complex disorder resulting from the interaction of intestinal microbiota with the host immune system in genetically susceptible individuals. The largest meta-analysis of genome-wide association to date identified 71 CD–susceptibility loci in individuals of European ancestry. An important epidemiological feature of CD is that it is 2–4 times more prevalent among individuals of Ashkenazi Jewish (AJ) descent compared to non-Jewish Europeans (NJ). To explore genetic variation associated with CD in AJs, we conducted a genome-wide association study (GWAS) by combining raw genotype data across 10 AJ cohorts consisting of 907 cases and 2,345 controls in the discovery stage, followed up by a replication study in 971 cases and 2,124 controls. We confirmed genome-wide significant associations of 9 known CD loci in AJs and replicated 3 additional loci with strong signal (p<5×10−6). Novel signals detected among AJs were mapped to chromosomes 5q21.1 (rs7705924, combined p = 2×10−8; combined odds ratio OR = 1.48), 2p15 (rs6545946, p = 7×10−9; OR = 1.16), 8q21.11 (rs12677663, p = 2×10−8; OR = 1.15), 10q26.3 (rs10734105, p = 3×10−8; OR = 1.27), and 11q12.1 (rs11229030, p = 8×10−9; OR = 1.15), implicating biologically plausible candidate genes, including RPL7, CPAMD8, PRG2, and PRG3. In all, the 16 replicated and newly discovered loci, in addition to the three coding NOD2 variants, accounted for 11.2% of the total genetic variance for CD risk in the AJ population. This study demonstrates the complementary value of genetic studies in the Ashkenazim