Flight-test nacelles

Design modifications for acoustically absorbing flight test nacelles of DC-8 turbofan engin

Beards and Texts: Images of masculinity in medieval German literature

Beards and Texts explores the literary portrayal of beards in medieval German texts from the mid-twelfth to the early sixteenth centuries. It argues that as the pre-eminent symbol for masculinity the beard played a distinctive role throughout the Middle Ages in literary discussions of such major themes as majesty and humanity. At the same time beards served as an important point of reference in didactic poetry concerned with wisdom, teaching and learning, and in comedic texts that were designed to make their audiences laugh, not least by submitting various figure-types to the indignity of having their beards manhandled. Four main chapters each offer a reading of a work or poetic tradition of particular significance (Pfaffe Konrad’s Rolandslied; Wolfram von Eschenbach’s Willehalm; ‘Sangspruchdichtung’; Heinrich Wittenwiler’s Ring), before examining cognate material of various kinds, including sources or later versions of the same story, manuscript variants and miniatures and further relevant beard-motifs from the same period. The book concludes by reviewing the portrayal of Jesus in vernacular German literature, which represents a special test-case in the literary history of beards. As the first study of its kind in medieval German studies, this investigation submits beard-motifs to sustained and detailed analysis in order to shed light both on medieval poetic techniques and the normative construction of masculinity in a wide range of literary genres

Sound Can Enhance the Analgesic Effect of Virtual Reality.

Virtual reality (VR) technology may serve as an effective non-pharmacological analgesic to aid pain management. During VR distraction the individual is immersed in a game presented through a head-mounted display (HMD). The technological level of the HMD can vary, as can the use of different input devices and the inclusion of sound. Whilst more technologically advanced designs may lead to more effective pain management the specific roles of individual components within such systems are not yet fully understood. Here the role of supplementary auditory information was explored due to its particular ecological relevance. Healthy adult participants took part in a series of cold-pressor trials submerging their hand in cold water for as long as possible. Individual pain tolerances were measured according to the time (in seconds) before the participant withdrew their hand. The concurrent use of a VR game and the inclusion of sound was varied systematically within participants. In keeping with previous literature, the use of a VR game increased pain tolerance across conditions. Highest pain tolerance was recorded when participants were simultaneously exposed to both the VR game and supplementary sound. The simultaneous inclusion of sound may therefore play an important role when designing VR to manage pain

Amine-terminated nanoparticle films: pattern deposition by a simple nanostencilling technique and stability studies under X-ray irradiation

Exploring the surface chemistry of nanopatterned amine-terminated nanoparticle films.</p

Fluorinated Tags to Study Protein Conformation and Interactions Using 19F NMR

The incorporation of fluorine atoms into a biomacromolecule provides a background-free and environmentally sensitive reporter of structure, conformation and interactions using 19F NMR. There are several methods to introduce the 19F reporter – either by synthetic incorporation via solid phase peptide synthesis; by suppressing the incorporation or biosynthesis of a natural amino acid and supplementing the growth media with a fluorinated counterpart during protein expression; and by genetic code expansion to add new amino acids to the amino acid alphabet. This review aims to discuss progress in the field of introducing fluorinated handles into biomolecules for NMR studies by post-translational bioconjugation or ‘fluorine-tagging’. We will discuss the range of chemical tagging ‘warheads’ that have been used, explore the applications of fluorine tags, discuss ways to enhance reporter sensitivity and how the signal to noise ratios can be boosted. Finally, we consider some key challenges of the field and offer some ideas for future directions

Cognitive transfer of spatial awareness states from immersive virtual environments to reality.

An individual's prior experience will influence how new visual information in a scene is perceived and remembered. Accuracy of memory performance per se is an imperfect reflection of the cognitive activity (awareness states) that underlies performance in memory tasks. The aim of this research is to investigate the effect of varied visual fidelity of training environments on the transfer of training to the real-world after exposure to immersive simulations representing a real-world scene. A between groups experiment was carried out to explore the effect of rendering quality on measurements of location-based recognition memory for objects and associated states of awareness. The immersive simulation, consisted of one room that was either rendered flat-shaded or using radiosity rendering. The simulation was displayed on a stereo head-tracked Head Mounted Display. Post exposure to the synthetic simulation, participants completed a memory recognition task conducted in a real-world scene by physically arranging objects in their physical form in a real world room. Participants also reported one of four states of awareness following object recognition. They were given several options of awareness states that reflected the level of visual mental imagery involved during retrieval, the familiarity of the recollection and related guesses. The scene incorporated objects that 'fitted' into the specific context of the real-world scene, referred to as consistent objects, and objects which were not related to the specific context of the real-world scene, referred to as inconsistent objects. A follow-up study was conducted a week after the initial test. Interestingly, results revealed a higher proportion of correct object recognition associated with mental imagery when participants were exposed to low fidelity flat-shaded training scenes rather than the radiosity rendered ones. Memory psychology indicates that awareness states based on visual imagery require stronger attentional processing in the first instance than those based on familiarity. A tentative claim would therefore be that those immersive environments that are distinctive because of their variation from 'real', such as flat-shaded environments, recruit stronger attentional resources. This additional attentional processing may bring about a change in participants' subjective experiences of 'remembering' when they later transfer the training from that environment into a real-world situation

National evaluation of the neighbourhood nurseries: integrated report

Report description: The NNI was launched in 2001 to provide high quality childcare in the most disadvantaged neighbourhoods of England, to help parents into employment, reduce child poverty and boost children’s development. By 2005 45,000 new childcare places had been created in approximately 1,400 neighbourhood nurseries. This report brings together the findings of the four individual strands of the National Evaluation of Neighbourhood Nurseries Initiative as shown above and makes a number of recommendations. The report shows the rationale for the government’s strategy in targeting disadvantaged neighbourhoods and in focusing on high quality childcare to provide the link between raising parental employment and income and improving children’s life chances

A phase II study of capecitabine and oxalplatin combination chemotherapy in patients with inoperable adenocarcinoma of the gall bladder or biliary tract

Background: Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study was conducted to determine the efficacy of capecitabine in combination with oxaliplatin in patients with inoperable gall bladder or biliary tract cancer. Methods: This was a Phase II, non-randomised, two-stage Simon design, multi-centre study. Ethics approval was sought and obtained by the North West MREC, and then locally by the West Glasgow Hospitals Research Ethics Com mittee. Eligible patients with inoperable locally advanced or metastatic adenocarcinoma of the gall bladder or biliary tract and with adequate performance status, haematologic, renal, and hepatic function were treated with capecit abine (1000 mg/m2 po, twice daily, days 1–14) and oxaliplatin (130 mg/m2 i.v., day 1) every 3 weeks for up to six cycles. The primary objective of the study was to determine the objective tumour response rates (complete and partial). The secondary objectives included assessment of toxicity, progression-free survival, and overall survival. Results: Forty-three patients were recruited between July 2003 and December 2005. The regimen was well tolerated with no grade 3/4 neutropenia or thrombocytopenia. Grade 3/4 sensory neuropathy was observed in six patients. Two-thirds of patients received their chemotherapy without any dose delays. Overall response rate was 23.8 % (95 % CI 12.05–39.5 %). Stable disease was observed in a further 13 patients (31 %) and progressive disease observed in 12 (28.6 %) of patients. The median progression-free survival was 4.6 months (95 % CI 2.8–6.4 months; Fig. 1) and the median overall survival 7.9 months (95 % CI 5.3–10.4 months; Fig. 2). Conclusion: Capecitabine combined with oxaliplatin has a lower disease control and shorter overall survival than the combination of cisplatin with gemcitabine which has subsequently become the standard of care in this disease. How ever, capecitabine in combination with oxaliplatin does have modest activity in this disease, and can be considered as an alternative treatment option for patients in whom cisplatin and/or gemcitabine are contra-indicated

Investigating local population dynamics of bottlenose dolphins in the northern Bahamas and the impact of hurricanes on survival

This study was made possible with financial support from Earthwatch Institute, Atlantis Blue Project Foundation, with permission to conduct research granted by the Bahamas Department of Marine Resources.Little Bahama Bank in the northern Bahamas supports several populations of bottlenose dolphins (Tursiops truncatus). We provide the first estimates of birth rate and age-class-specific apparent survival rates for the local South Abaco population using data from a long-term (1997–2014) photo-identification (photo-ID) study and use the estimated life history parameters in a population viability analysis (PVA) to predict future population trends. Hurricane events are predicted to become more intense due to climate change but knowledge of how hurricanes may impact cetacean populations is limited. Little Bahama Bank is subject to hurricane activity, so we also investigate the potential impact of hurricanes on calf, juvenile and adult survival. Photo-ID data confirmed the existence of a core adult population with relatively high site fidelity in South Abaco, but also evidence of transient animals. Estimated annual birth rate was 0.278 (95% CI: 0.241–0.337). We found strong support for a decline in apparent survival for all age-classes. Estimated survival declined by 9% in adults (0.941 in 1998, to 0.855 in 2013), 5% in juveniles (0.820 in 2000, to 0.767 in 2013) and 36% in calves (0.970 in 1997, to 0.606 in 2013). Evidence that survival was influenced by repeated hurricane activity leading to increased mortality and/or emigration was stronger for calves and juveniles than for adults. PVA simulations of an assumed isolated South Abaco population showed that declines would lead to extinction within decades, even under the most optimistic scenario. Future work should focus on establishing if South Abaco is part of natural source–sink metapopulation dynamics on Little Bahama Bank by assessing trends in abundance in local populations and establishing how they interact; this will be important for assessing their conservation status in a potentially increasingly changing environment.Publisher PDFPeer reviewe

Rotational Feshbach Resonances in Ultracold Molecular Collisions

In collisions at ultralow temperatures, molecules will possess Feshbach resonances, foreign to ultracold atoms, whose virtual excited states consist of rotations of the molecules. We estimate the mean spacing and mean widths of these resonant states, exploiting the fact the molecular collisions at low energy display chaotic motion. As examples, we consider the experimentally relevant molecules O_2, OH, and PbO. The density of s-wave resonant states for these species is quite high, implying that a large number of narrow resonant states will exist.Comment: 4 pages, 2 figure