335 research outputs found
Particle and particle pair dispersion in turbulence modeled with spatially and temporally correlated stochastic processes
In this paper we present a new model for modeling the diffusion and relative
dispersion of particles in homogeneous isotropic turbulence. We use an
Heisenberg-like Hamiltonian to incorporate spatial correlations between fluid
particles, which are modeled by stochastic processes correlated in time. We are
able to reproduce the ballistic regime in the mean squared displacement of
single particles and the transition to a normal diffusion regime for long
times. For the dispersion of particle pairs we find a -dependence of the
mean squared separation at short times and a -dependence for long ones. For
intermediate times indications for a Richardson law are observed in
certain situations. Finally the influence of inertia of real particles on the
dispersion is investigated.Comment: 10 pages, 7 figures, 1 tabl
Summary of abalone poaching trend estimates as updated in 2013
The analysis in 2013 using up to four separate indicators to estimate the trend in poaching indicates that the target of a 15% per annum reduction in poaching since 2009 has not been reached. In fact, indices suggest a continued and substantial increase in poaching, commencing from October 2009 (note that trends are assessed per ‘model year’, that runs from October in one year (y-1) to September in the following year, y). The 15% per annum decline was a key criterion for rebuilding the abalone resource and was amongst the conditions set by the Minister associated with reopening the fishery. While at this time some four years after re-opening of the fishery, a net 50% reduction in poaching was required under the rebuilding plan, results indicated that poaching has increased by some 150%
Sensitivity and Response of Bhutanese Glaciers to Atmospheric Warming
Glacierized change in the Himalayas affects river-discharge, hydro-energy and agricultural production, and Glacial Lake Outburst Flood potential, but its quantification and extent of impacts remains highly uncertain. Here we present conservative, comprehensive and quantitative predictions for glacier area and meltwater flux changes in Bhutan, monsoonal Himalayas. In particular, we quantify the uncertainties associated with the glacier area and meltwater flux changes due to uncertainty in climate data, a critical problem for much of High Asia. Based on a suite of gridded climate data and a robust glacier melt model, our results show that glacier area and meltwater change projections can vary by an order of magnitude for different climate datasets. However, the most conservative results indicate that, even if climate were to remain at the present-day mean values, almost 10% of Bhutan s glacierized area would vanish and the meltwater flux would drop by as much as 30%. Under the conservative scenario of an additional 1 C regional warming, glacier retreat is going to continue until about 25% of Bhutan s glacierized area will have disappeared and the annual meltwater flux, after an initial spike, would drop by as much as 65%. Citatio
Endothelin-1 (ET-1) blockade improves mesenteric perfusion in a porcine low cardiac output model
Microbial translocation and microbiome dsybiosis in HIV-associated immune activation.
CAPRISA, 2016.Abstract available in pdf
Dogs as carriers of virulent and resistant genotypes of Clostridioides difficile
Abstract While previous research on zoonotic transmission of community-acquired Clostridioides difficile infection (CA-CDI) focused on food-producing animals, the present study aimed to investigate whether dogs are carriers of resistant and/or virulent C. difficile strains. Rectal swabs were collected from 323 dogs and 38 C. difficile isolates (11.8%) were obtained. Isolates were characterized by antimicrobial susceptibility testing, whole-genome sequencing (WGS) and a DNA hybridization assay. Multilocus sequence typing (MLST), core genome MLST (cgMLST) and screening for virulence and antimicrobial resistance genes were performed based on WGS. Minimum inhibitory concentrations for erythromycin, clindamycin, tetracycline, vancomycin and metronidazole were determined by E-test. Out of 38 C. difficile isolates, 28 (73.7%) carried genes for toxins. The majority of isolates belonged to MLST sequence types (STs) of clade I and one to clade V. Several isolates belonged to STs previously associated with human CA-CDI. However, cgMLST showed low genetic relatedness between the isolates of this study and C. difficile strains isolated from humans in Austria for which genome sequences were publicly available. Four isolates (10.5%) displayed resistance to three of the tested antimicrobial agents. Isolates exhibited resistance to erythromycin, clindamycin, tetracycline and metronidazole. These phenotypic resistances were supported by the presence of the resistance genes erm(B), cfr(C) and tet(M). All isolates were susceptible to vancomycin. Our results indicate that dogs may carry virulent and antimicrobial-resistant C. difficile strains.1 Introduction 2 Methods 2.1 Sampling and ethics 2.2 Isolation and identification of Clostridioides difficile 2.3 Antimicrobial susceptibility testing 2.4 Whole-genome sequencing and comparative genomic analysis 2.5 Statistical analysis 3 Results 3.1 Prevalence of Clostridioides difficile and risk factors for shedding 3.2 Antimicrobial susceptibility testing and detection of antimicrobial resistance determinants 3.3 Genomic characterization of canine Clostridioides difficile 3.4 Genome annotation and comparison 4 Discussio
Dogs as carriers of virulent and resistant genotypes of Clostridioides difficile
While previous research on zoonotic transmission of community-acquired Clostridioides difficile infection (CA-CDI) focused on food-producing animals, the present study aimed to investigate whether dogs are carriers of resistant and/or virulent C. difficile strains. Rectal swabs were collected from 323 dogs and 38 C. difficile isolates (11.8%) were obtained. Isolates were characterized by antimicrobial susceptibility testing, whole-genome sequencing (WGS) and a DNA hybridization assay. Multilocus sequence typing (MLST), core genome MLST (cgMLST) and screening for virulence and antimicrobial resistance genes were performed based on WGS. Minimum inhibitory concentrations for erythromycin, clindamycin, tetracycline, vancomycin and metronidazole were determined by E-test. Out of 38 C. difficile isolates, 28 (73.7%) carried genes for toxins. The majority of isolates belonged to MLST sequence types (STs) of clade I and one to clade V. Several isolates belonged to STs previously associated with human CA-CDI. However, cgMLST showed low genetic relatedness between the isolates of this study and C. difficile strains isolated from humans in Austria for which genome sequences were publicly available. Four isolates (10.5%) displayed resistance to three of the tested antimicrobial agents. Isolates exhibited resistance to erythromycin, clindamycin, tetracycline and metronidazole. These phenotypic resistances were supported by the presence of the resistance genes erm(B), cfr(C) and tet(M). All isolates were susceptible to vancomycin. Our results indicate that dogs may carry virulent and antimicrobial-resistant C. difficile strains
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