1,653 research outputs found
Discrete-time Markov chain approach to contact-based disease spreading in complex networks
Many epidemic processes in networks spread by stochastic contacts among their
connected vertices. There are two limiting cases widely analyzed in the physics
literature, the so-called contact process (CP) where the contagion is expanded
at a certain rate from an infected vertex to one neighbor at a time, and the
reactive process (RP) in which an infected individual effectively contacts all
its neighbors to expand the epidemics. However, a more realistic scenario is
obtained from the interpolation between these two cases, considering a certain
number of stochastic contacts per unit time. Here we propose a discrete-time
formulation of the problem of contact-based epidemic spreading. We resolve a
family of models, parameterized by the number of stochastic contact trials per
unit time, that range from the CP to the RP. In contrast to the common
heterogeneous mean-field approach, we focus on the probability of infection of
individual nodes. Using this formulation, we can construct the whole phase
diagram of the different infection models and determine their critical
properties.Comment: 6 pages, 4 figures. Europhys Lett (in press 2010
Emergence of influential spreaders in modified rumor models
The burst in the use of online social networks over the last decade has
provided evidence that current rumor spreading models miss some fundamental
ingredients in order to reproduce how information is disseminated. In
particular, recent literature has revealed that these models fail to reproduce
the fact that some nodes in a network have an influential role when it comes to
spread a piece of information. In this work, we introduce two mechanisms with
the aim of filling the gap between theoretical and experimental results. The
first model introduces the assumption that spreaders are not always active
whereas the second model considers the possibility that an ignorant is not
interested in spreading the rumor. In both cases, results from numerical
simulations show a higher adhesion to real data than classical rumor spreading
models. Our results shed some light on the mechanisms underlying the spreading
of information and ideas in large social systems and pave the way for more
realistic diffusion models.Comment: 14 Pages, 6 figures, accepted for publication in Journal of
Statistical Physic
Optimal map of the modular structure of complex networks
Modular structure is pervasive in many complex networks of interactions
observed in natural, social and technological sciences. Its study sheds light
on the relation between the structure and function of complex systems.
Generally speaking, modules are islands of highly connected nodes separated by
a relatively small number of links. Every module can have contributions of
links from any node in the network. The challenge is to disentangle these
contributions to understand how the modular structure is built. The main
problem is that the analysis of a certain partition into modules involves, in
principle, as many data as number of modules times number of nodes. To confront
this challenge, here we first define the contribution matrix, the mathematical
object containing all the information about the partition of interest, and
after, we use a Truncated Singular Value Decomposition to extract the best
representation of this matrix in a plane. The analysis of this projection allow
us to scrutinize the skeleton of the modular structure, revealing the structure
of individual modules and their interrelations.Comment: 21 pages, 10 figure
The topology of a discussion: the #occupy case
We analyse a large sample of the Twitter activity developed around the social
movement 'Occupy Wall Street' to study the complex interactions between the
human communication activity and the semantic content of a discussion. We use a
network approach based on the analysis of the bipartite graph @Users-#Hashtags
and of its projections: the 'semantic network', whose nodes are hashtags, and
the 'users interest network', whose nodes are users In the first instance, we
find out that discussion topics (#hashtags) present a high heterogeneity, with
the distinct role of the communication hubs where most the 'opinion traffic'
passes through. In the second case, the self-organization process of users
activity leads to the emergence of two classes of communicators: the
'professionals' and the 'amateurs'. Moreover the network presents a strong
community structure, based on the differentiation of the semantic topics, and a
high level of structural robustness when a certain set of topics are censored
and/or accounts are removed. Analysing the characteristics the @Users-#Hashtags
network we can distinguish three phases of the discussion about the movement.
Each phase corresponds to specific moment of the movement: from declaration of
intent, organisation and development and the final phase of political
reactions. Each phase is characterised by the presence of specific #hashtags in
the discussion. Keywords: Twitter, Network analysisComment: 13 pages, 9 figure
Levels, sources and seasonality of coarse particles (PM10-PM2.5) in three European capitals e implications for particulate pollution control
Coarse particles of aerodynamic diameter between 2.5 and 10 mm (PMc) are produced by a range of natural (windblown dust and sea sprays) and anthropogenic processes (non-exhaust vehicle emissions, industrial, agriculture, construction and quarrying activities). Although current ambient air quality regulations focus on PM2.5 and PM10, coarse particles are of interest from a public health point of view as they have been associated with certain mortality and morbidity outcomes. In this paper, an analysis of coarse particle levels in three European capitals (London, Madrid and Athens) is presented and discussed. For all three cities we analysed data from both traffic and urban background monitoring sites. The results showed that the levels of coarse particles present significant seasonal, weekly and daily variability. Their wind driven and non-wind driven resuspension as well as their roadside increment due to traffic were estimated. Both the local meteorological conditions and the air mass history indicating long-range atmospheric transport of particles of natural origin are significant parameters that influence the levels of coarse particles in the three cities especially during episodic events
Locating privileged spreaders on an Online Social Network
Social media have provided plentiful evidence of their capacity for
information diffusion. Fads and rumors, but also social unrest and riots travel
fast and affect large fractions of the population participating in online
social networks (OSNs). This has spurred much research regarding the mechanisms
that underlie social contagion, and also who (if any) can unleash system-wide
information dissemination. Access to real data, both regarding topology --the
network of friendships-- and dynamics --the actual way in which OSNs users
interact--, is crucial to decipher how the former facilitates the latter's
success, understood as efficiency in information spreading. With the
quantitative analysis that stems from complex network theory, we discuss who
(and why) has privileged spreading capabilities when it comes to information
diffusion. This is done considering the evolution of an episode of political
protest which took place in Spain, spanning one month in 2011.Comment: 7 pages, 4 figure
FORMULATION AND EVALUATION OF GLICLAZIDE NANOSPONGES
Objective: The objective of the present study was to develop and characterize an optimal stable nanosponges of Gliclazide (GLZ) by using the emulsion solvent diffusion method and aimed to increase its bioavailability and release the drug in sustained and controlled manner.
Methods: The GLZ nanosponge was prepared by emulsion solvent diffusion method using different drug-polymer ratios (1:1 to 1:5) Eudragit S100 is used as a polymer. Differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) estimated the compatibility of GLZ with polymer. All formulations evaluated for production yield, entrapment efficiency, in vitro drug release, scanning electron microscopy (SEM) and stability studies.
Results: The DSC and FTIR Studies revealed that no interaction between drug and polymer. The Production yield of all batches in the range of 73.8±0.30 to 85.6±0.32. Batch F3 showed the highest production yield, the entrapment efficiency of batch F3 70.6±0.77. The average particle size ranges from 303±2.36 to 680±2.50 nm. By the end of 10th hour F3 formulation shown highest drug release was found to be 94.40±1.12%. The release kinetics of the optimized formulation shows zero-order drug release. The stability study indicates no significant change in the in vitro dissolution profile of optimized formulation.
Conclusion: The results of various evaluation parameters, revealed that GLZ nanosponges would be possible alternative delivery systems to conventional formulation to improve its bioavailability, the emulsion solvent diffusion method is best method for preparation of nanosponges and release the drug in sustained and controlled manner
Indication of Anisotropy in Electromagnetic Propagation over Cosmological Distances
We report a systematic rotation of the plane of polarization of
electromagnetic radiation propagating over cosmological distances. The effect
is extracted independently from Faraday rotation, and found to be correlated
with the angular positions and distances to the sources. Monte Carlo analysis
yields probabilistic P-values of order 10^(-3) for this to occur as a
fluctuation. A fit yields a birefringence scale of order 10^(25) meters.
Dependence on redshift z rules out a local effect. Barring hidden systematic
bias in the data, the correlation indicates a new cosmological effect.Comment: 5 pages, 1 figure, ReVTeX. For more information, see
http://www.cc.rochester.edu/college/rtc/Borge/aniso.htm
- …