Automatic best wireless network selection based on key performance indicators

Introducing cognitive mechanisms at the application layer may lead to the possibility of an automatic selection of the wireless network that can guarantee best perceived experience by the final user. This chapter investigates this approach based on the concept of Quality of Experience (QoE), by introducing the use of application layer parameters, namely Key Performance Indicators (KPIs). KPIs are defined for different traffic types based on experimental data. A model for an ap- plication layer cognitive engine is presented, whose goal is to identify and select, based on KPIs, the best wireless network among available ones. An experimenta- tion for the VoIP case, that foresees the use of the One-way end-to-end delay (OED) and the Mean Opinion Score (MOS) as KPIs is presented. This first implementation of the cognitive engine selects the network that, in that specific instant, offers the best QoE based on real captured data. To our knowledge, this is the first example of a cognitive engine that achieves best QoE in a context of heterogeneous wireless networks

How immunosenescence and inflammaging may contribute to hyperinflammatory syndrome in COVID-19

Aging is characterized by the dynamic remodeling of the immune system designated “immunosenescence,” and is associated with altered hematopoiesis, thymic involution, and lifelong immune stimulation by multitudinous chronic stressors, including the cytomegalovirus (CMV). Such alterations may contribute to a lowered proportion of naïve T-cells and to reduced diversity of the T-cell repertoire. In the peripheral circulation, a shift occurs towards accumulations of T and B-cell populations with memory phenotypes, and to accumulation of putatively senescent and exhausted immune cells. The aging-related accumulations of functionally exhausted memory T lymphocytes, commonly secreting pro-inflammatory cytokines, together with mediators and factors of the innate immune system, are considered to contribute to the low-grade inflammation (inflammaging) often observed in elderly people. These senescent immune cells not only secrete inflammatory mediators, but are also able to negatively modulate their environments. In this review, we give a short summary of the ways that immunosenescence, inflammaging, and CMV infection may cause insufficient immune responses, contribute to the establishment of the hyperinflammatory syndrome and impact the severity of the coronavirus disease 2019 (COVID-19) in elderly people

Dispersal of larval and juvenile seabream: Implications for Mediterranean marine protected areas

In the marine context, information about dispersal is essential for the design of networks of marine protected areas (MPAs). Generally, most of the dispersal of demersal fishes is thought to be driven by the transport of eggs and larvae in currents, with the potential contribution of dispersal in later life stages relatively minimal.Using otolith chemistry analyses, we estimate dispersal patterns across a spatial scale of approximately 180. km at both propagule (i.e. eggs and larvae) and juvenile (i.e. between settlement and recruitment) stages of a Mediterranean coastal fishery species, the two-banded seabream Diplodus vulgaris. We detected three major natal sources of propagules replenishing local populations in the entire study area, suggesting that propagule dispersal distance extends to at least 90. km. For the juvenile stage, we detected dispersal of up to 165. km. Our work highlights the surprising and significant role of dispersal during the juvenile life stages as an important mechanism connecting populations. Such new insights are crucial for creating effective management strategies (e.g. MPAs and MPA networks) and to gain support from policymakers and stakeholders, highlighting that MPA benefits can extend well beyond MPA borders, and not only via dispersal of eggs and larvae, but also through movement by juveniles

Fundamental Limits of Low-Density Spreading NOMA with Fading

Spectral efficiency of low-density spreading non-orthogonal multiple access channels in the presence of fading is derived for linear detection with independent decoding as well as optimum decoding. The large system limit, where both the number of users and number of signal dimensions grow with fixed ratio, called load, is considered. In the case of optimum decoding, it is found that low-density spreading underperforms dense spreading for all loads. Conversely, linear detection is characterized by different behaviors in the underloaded vs. overloaded regimes. In particular, it is shown that spectral efficiency changes smoothly as load increases. However, in the overloaded regime, the spectral efficiency of low- density spreading is higher than that of dense spreading

Superoptimal Preconditioned Conjugate Gradient Iteration for Image Deblurring

We study the superoptimal Frobenius operators in the two-level circulant algebra. We consider two specific viewpoints: ( 1) the regularizing properties in imaging and ( 2) the computational effort in connection with the preconditioned conjugate gradient method. Some numerical experiments illustrating the effectiveness of the proposed technique are given and discussed

Rapamycin and HIV Replication in Liver Transplant Recipients

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Environmental monitoring of a Sardinian earthen dwelling during the summer season

Increasing interest in earth architecture has led to the development of new international norms regarding these structures. Although Italy has no specific legislation for this building type, both national laws for the safeguard of rural architecture and regional norms regarding the conservation of historical centers have considerably slowed down the pace of their destruction. This is particularly true for Sardinia, which maintains a conspicuous heritage of "raw earth" architecture, mostly in the old town centers of the Campidano plain and in its adjacent valley. Due to the current legislation on energy efficiency in buildings, it has become essential – particularly for the Sardinian region – to define guidelines for the improvement of energy efficiency for this existing building heritage and identify the best parameters for their energetic classification. Currently, these constructions are heavily penalized by the gap that persists between the requirements of current energy balance evaluations, calculated upon heating and domestic hot water energy demands, and the actual year-round energy performance, which also includes the summer season. Moreover, this building type has a low lifecycle environmental impact, but this aspect is not properly "rewarded" by Italian regulations. The study proposed herein firstly took into account the simulation of the thermal transient characteristics of the adobe wall (brick made of clay, earth and straw, forged with wooden molds and sun dried). Analytical calculations were performed using a transient model, assuming sinusoidal behavior of all the parameters acting on the system. The results showed a high thermal inertia of the material and a good ability in dampening the external thermal wave. Next, we conducted an internal and external environmental monitoring of an existing earthen residential building in Sardinia ("Casa Mancosu", Serramanna, VS), which provided the experimental data for the evaluation of the whole building thermo-physical behavior. The measurements were taken during the 2010 summer season; the dwelling was not cooled by an air conditioning system. Thermal comfort analyses based on these experimental data indicate that the roof is the "weak" component, creating local discomfort due to radiant asymmetry. The described methodology is expected to be applicable also to the many buildings of this geographical area similar to the examined one