Scale Invariance and the AdS/CFT Correspondence

Using the AdS/CFT correspondence, we show that the Anti-de Sitter (AdS) rotating (Kerr) black holes in five and seven dimensions provide us with examples of non-trivial field theories which are scale, but not conformally invariant. This is demonstrated by our computation of the actions and the stress-energy tensors of the four and six dimensional field theories residing on the boundary of these Kerr-AdS black holes spacetimes.Comment: 3 pages. LaTeX, IJMP style. Contribution to proceedings of DPF 2000, held at Ohio State

Underdetermined blind source separation based on Fuzzy C-Means and Semi-Nonnegative Matrix Factorization

Conventional blind source separation is based on over-determined with more sensors than sources but the underdetermined is a challenging case and more convenient to actual situation. Non-negative Matrix Factorization (NMF) has been widely applied to Blind Source Separation (BSS) problems. However, the separation results are sensitive to the initialization of parameters of NMF. Avoiding the subjectivity of choosing parameters, we used the Fuzzy C-Means (FCM) clustering technique to estimate the mixing matrix and to reduce the requirement for sparsity. Also, decreasing the constraints is regarded in this paper by using Semi-NMF. In this paper we propose a new two-step algorithm in order to solve the underdetermined blind source separation. We show how to combine the FCM clustering technique with the gradient-based NMF with the multi-layer technique. The simulation results show that our proposed algorithm can separate the source signals with high signal-to-noise ratio and quite low cost time compared with some algorithms

Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series)

The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH). Mutations in bone morphogenetic protein type 2 receptor (BMPR2) have been identified as the most common genetic cause of PAH and females with BMPR2 mutations are 2.5 times as likely to develop heritable forms of PAH than males. Higher levels of estrogen have also been observed in males with PAH, implicating sex hormones in PAH pathogenesis. Recently, the estrogen metabolite 16α-OHE1 (hydroxyestrone) was implicated in the regulation of miR29, a microRNA involved in modulating energy metabolism. In females, decreased miR96 enhances serotonin’s effect by upregulating the 5-hydroxytryptamine 1B (5HT1B) receptor. Because PAH is characterized as a quasi-malignant disease, likely due to BMPR2 loss of function, altered signaling pathways that sustain this cancer-like phenotype are being explored. Extracellular signal–regulated kinases 1 and 2 and p38 mitogen-activated protein kinases (MAPKs) play a critical role in proliferation and cell motility, and dysregulated MAPK signaling is observed in various experimental models of PAH. Wnt signaling pathways preserve pulmonary vascular homeostasis, and dysregulation of this pathway could contribute to limited vascular regeneration in response to injury. In this review, we take a closer look at sex, sex hormones, and the interplay between sex hormones and microRNA regulation. We also focus on MAPK and Wnt signaling pathways in the emergence of a proproliferative, antiapoptotic endothelial phenotype, which then orchestrates an angioproliferative process of vascular remodeling, with the hope of developing novel therapies that could reverse the phenotype

DD-dimensional charged Anti-de-Sitter black holes in f(T)f(T) gravity

We present a $D$-dimensional charged Anti-de-Sitter black hole solutions in $f(T)$ gravity, where $f(T)=T+\beta T^2$ and $D \geq 4$. These solutions are characterized by flat or cylindrical horizons. The interesting feature of these solutions is the existence of inseparable electric monopole and quadrupole terms in the potential which share related momenta, in contrast with most of the known charged black hole solutions in General Relativity and its extensions. Furthermore, these solutions have curvature singularities which are milder than those of the known charged black hole solutions in General Relativity and Teleparallel Gravity. This feature can be shown by calculating some invariants of curvature and torsion tensors. Furthermore, we calculate the total energy of these black holes using the energy-momentum tensor. Finally, we show that these charged black hole solutions violate the first law of thermodynamics in agreement with previous results.Comment: 11 Pages, will appear in JHE

Higher Dimensional Taub-NUTs and Taub-Bolts in Einstein-Maxwell Gravity

We present a class of higher dimensional solutions to Einstein-Maxwell equations in d-dimensions. These solutions are asymptotically locally flat, de-Sitter, or anti-de Sitter space-times. The solutions we obtained depend on two extra parameters other than the mass and the nut charge. These two parameters are the electric charge, q and the electric potential at infinity, V, which has a non-trivial contribution. We Analyze the conditions one can impose to obtain Taub-Nut or Taub-Bolt space-times, including the four-dimensional case. We found that in the nut case these conditions coincide with that coming from the regularity of the one-form potential at the horizon. Furthermore, the mass parameter for the higher dimensional solutions depends on the nut charge and the electric charge or the potential at infinity.Comment: 11 pages, LaTe

On the Chemistry of Hydrides of N Atoms and O+ Ions

Previous work by various authors has suggested that the detection by Herschel/HIFI of nitrogen hydrides along the low-density lines of sight toward G10.6-0.4 (W31C) cannot be accounted for by gas-phase chemical models. In this paper we investigate the role of surface reactions on dust grains in diffuse regions, and we find that formation of the hydrides by surface reactions on dust grains with efficiency comparable to that for H2 formation reconciles models with observations of nitrogen hydrides. However, similar surface reactions do not contribute significantly to the hydrides of O+ ions detected by Herschel/HIFI that are present along many sight lines in the Galaxy. The O+ hydrides can be accounted for by conventional gas-phase chemistry either in diffuse clouds of very low density with normal cosmic-ray fluxes or in somewhat denser diffuse clouds with high cosmic-ray fluxes. Hydride chemistry in dense dark clouds appears to be dominated by gas-phase ion–molecule reactions

A Voting-Based System for Ethical Decision Making

We present a general approach to automating ethical decisions, drawing on machine learning and computational social choice. In a nutshell, we propose to learn a model of societal preferences, and, when faced with a specific ethical dilemma at runtime, efficiently aggregate those preferences to identify a desirable choice. We provide a concrete algorithm that instantiates our approach; some of its crucial steps are informed by a new theory of swap-dominance efficient voting rules. Finally, we implement and evaluate a system for ethical decision making in the autonomous vehicle domain, using preference data collected from 1.3 million people through the Moral Machine website.Comment: 25 pages; paper has been reorganized, related work and discussion sections have been expande

Coenzyme Q10 deficiencies: pathways in yeast and humans.

Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant. In human and yeast cells, CoQ synthesis derives from aromatic ring precursors and the isoprene biosynthetic pathway. Saccharomyces cerevisiae coq mutants provide a powerful model for our understanding of CoQ biosynthesis. This review focusses on the biosynthesis of CoQ in yeast and the relevance of this model to CoQ biosynthesis in human cells. The COQ1-COQ11 yeast genes are required for efficient biosynthesis of yeast CoQ. Expression of human homologs of yeast COQ1-COQ10 genes restore CoQ biosynthesis in the corresponding yeast coq mutants, indicating profound functional conservation. Thus, yeast provides a simple yet effective model to investigate and define the function and possible pathology of human COQ (yeast or human gene involved in CoQ biosynthesis) gene polymorphisms and mutations. Biosynthesis of CoQ in yeast and human cells depends on high molecular mass multisubunit complexes consisting of several of the COQ gene products, as well as CoQ itself and CoQ intermediates. The CoQ synthome in yeast or Complex Q in human cells, is essential for de novo biosynthesis of CoQ. Although some human CoQ deficiencies respond to dietary supplementation with CoQ, in general the uptake and assimilation of this very hydrophobic lipid is inefficient. Simple natural products may serve as alternate ring precursors in CoQ biosynthesis in both yeast and human cells, and these compounds may act to enhance biosynthesis of CoQ or may bypass certain deficient steps in the CoQ biosynthetic pathway