25 research outputs found
A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma - a case report with EGFR copy number analysis
<p>Abstract</p> <p>Background</p> <p>Small cell neuroendocrine carcinoma (SNEC) of maxillary sinus is a rare and aggressive malignancy. A tumor with squamous cell carcinoma, adenocarcinoma and SNEC co-existence is extremely rare.</p> <p>Case presentation</p> <p>We present a colliding tumor of squamous cell, adenocarcinoma and SNEC in maxillary sinus. The clinical features, diagnosis and EGFR flourescence in situ hybridization (FISH) study are presented. A 52-year-old female had a 1-month history of progressing left cheek swelling and purulent rhinorrhea. Magnetic resonance imaging showed a tumor involving left maxilla and orbital floor. Excision of tumor was done and the defect was reconstructed with free flap. The pathology revealed a malignant tumor composed of squamous cell carcinoma, adenocarcinoma and SNEC components. EGFR FISH study showed no gene amplification in 3 components of this tumor. The tumor progressed rapidly and the patient expired at 8 months after surgery.</p> <p>Conclusion</p> <p>A colliding tumor of squamous cell, adenocarcinoma and neuroendocrine carcinoma in maxillary sinus was aggressive in behavior and the treatment response was poor due to the complexity of tumor.</p
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters
Microbial Biotechnolog
ConstrucciĂłn de proyectos de tecnologĂas emergentes en ambientes a distancia: alcances y oportunidades
1. IntroducciĂłn; 2. Marco conceptual; 2.1 TecnologĂas emergentes en ambientes educativos; 2.2 ConstrucciĂłn de conocimiento en ambientes a distancia; 3. MetodologĂa; 4. Resultados; 5. AnĂĄlisis de datos; 6. Conclusiones y discusiĂłn; 7. Referencia