A self-contained wind speed, direction and location system for buoys and ships in the World Ocean Circulation Experiment

Knowledge of the absolute wind velocity near the surface of the ocean is a requirement of the World Ocean Circulation Experiment (WOCE) and other large programs directed towards understanding air-sea interactions and how ocean circulation and climate are interrelated. The measurement is made possible using IMET (Improved METeorology) modules, a next generation meteorological data acquisition system developed as part of the WOCE program. An IMET system consists of a set of intelligent modules for each measurement variable, with data being recorded on a computer, typically PC-based. The IMET wind module includes a propeller for wind speed, a vane and optical encoder for wind direction, a flux gate compass for the north reference, and microprocessor-based electronics for control and data formatting. The IMET Global Positioning System (GPS) module includes a five chanel GPS receiver and microprocessor based electronics for control and data formatting. These modules, as part of the complete measurement suite, result in a self-contained system that can make accurate measurements from research ships, drifting and moored buoys, and volunteer observing ships (VOS).Funding was provided by Grant No. OCE-8709614 from the National Science Foundation

Development of an autonomous aerosol sampler for ocean buoys and land sites

The authors have successfully designed, built and tested an aerosol sampler which is capable of collecting, in an unattended manner, a time-series set of aerosol samples (aerosol-embedded filters) from moored ocean buoys and remote areas on land. Research on aerosols, in particular, and atmospheric chemistry, in general, has not been previously attempted from buoys. Aerosols entering and leaving the ocean play an important role in climate change, ocean productivity, pollutant transport and atmospheric optics. This report discusses (1) the scientific applications of a buoy-mounted aerosol sampler, (2) the advantages of using buoys as research platforms and (3) the authors' new instrument. Also discussed are the results of a four month test of the aerosol sampler on the AEROCE (Atmosphere/Ocean Chemistry Experiment) tower in Bermuda and the results of a three month test on a buoy moored in Vineyard Sound off Woods Hole, MA USA. The direct comparison between WHOI filters and AEROCE filters from the Bermuda tower is very encouraging as the Fe concentrations of aerosols compare to within 10-15% over a wide range of values. Aerosol sampling from a buoy moored in coastal waters was successfully tested under a variety of atmospheric and oceanic conditions.Funding was provided by the National Science Foundation through Grant No. OCE-943212

Arabian Sea mixed layer dynamics experiment : mooring deployment cruise report R/V Thomas Thompson cruise number 40, 11 October-25 October 1994

An array of surface and subsurface moorings were deployed in the Arabian Sea to provide high quality time series of local forcing and upper ocean currents, temperature, and conductivity in order to investigate the dynamics of the ocean's response to the monsoonal forcing characteristic of the area. The moored array was deployed during R/V Thomas Thompson cruise number 40, One Woods Hole Oceanographic Institution (WHOI) surface mooring, two Scripps Institution of Oceanography (SIO) surface moorings and two University of Washington (UW) Profiling Current Meter moorings were deployed. The moorings were deployed for a period of one year beginning in October 1994 as part of the Office of Naval Research (ONR) funded Arabian Sea experiment. Two six month deployments were planned. The moorings were deployed at 15.5°N 61.5°E (WHOI), 15.7°N 61.3°E (SIO), 15.3°N 61.3°E (SIO), 15.7°N 61.7°E (UW), and 15.3°N 61.7°E (UW). The WHOI surface mooring was outfitted with two meteorological data collection systems. A Vector Averaging Wind Recorder (VAWR) and an IMET system made measurements of wind speed and direction, sea surface temperature, air temperature, short wave radiation, long wave radiation, barometric pressure, relative humidity and precipitation. Subsurface instrumentation included Vector Measuring Current Meters (VMCMs), Multi-Variable Moored Systems (MVMS), conductivity and temperature recorders and single point temperature recorders. Expendable bathythermograph (XBT) data and CTD data were collected while in transit to the site and between mooring locations. This report describes in a general manner the work that took place during R/V Thomas Thompson cruise number 40 which was the initial deployment cruise for this moored array. A detailed description of the WHOI surface mooring and its instrumentation is provided. Information about the XBT and CTD data collected during the cruise is also included.Funding was provided by the Office of Naval Research under Grant No. N00014-94-1-0161

Predictors of Long-term Exercise Maintenance among College Aged Adults: Role of Body Image Anxiety

Background and Purpose: Participation in regular exercise is low among young adults and is contributing to a rapid increase in obesity and chronic health conditions. Enhancing motivation is a key element in exercise initiation and maintenance. The current investigation considers factors relevant to the transtheoretical model (TTM), self-determination theory (SDT), self-efficacy (SE), and body image anxiety (BIA) in relation to college students’ motivation to exercise. Design and Main Outcome Measures: In this cross sectional study, lower division college students (N=614, 64% female, 36% male) completed an online survey of exercise behavior, motivation, SE and BIA. Results: BIA was related to both controlled extrinsic (external and introjected regulations) and autonomous extrinsic (integrated regulation) SDT motivational variables, as well as intrinsic motivation. Exercise maintenance was most strongly associated with integrated regulation, a “selfdetermined” motivational state, and SE. Conclusion: The current study provides support for the central tenet of SDT indicating that intrinsic and extrinsic motivation are not mutually exclusive constructs. Helping individuals with BIA develop a more intrinsic approach to exercise is integral for fostering long-term exercise maintenance. Thus, future research should focus on developing interventions that enhance integrated regulation and SE in order to promote exercise maintenance and reduce associated BIA

Factors Influencing the Participation of Older People in Clinical Trials : Data Analysis from the MAVIS Trial

Peer reviewedPostprin

Assessment of ibrutinib plus rituximab in front-line CLL (FLAIR trial): study protocol for a phase III randomised controlled trial

Background Treatment of chronic lymphocytic leukaemia (CLL) has seen a substantial improvement over the last few years. Combination immunochemotherapy, such as fludarabine, cyclophosphamide and rituximab (FCR), is now standard first-line therapy. However, the majority of patients relapse and require further therapy, and so new, effective, targeted therapies that improve remission rates, reduce relapses, and have fewer side effects, are required. The FLAIR trial will assess whether ibrutinib plus rituximab (IR) is superior to FCR in terms of progression-free survival (PFS). Methods/design FLAIR is a phase III, multicentre, randomised, controlled, open, parallel-group trial in patients with previously untreated CLL. A total of 754 participants will be randomised on a 1:1 basis to receive standard therapy with FCR or IR. Participants randomised to FCR will receive a maximum of six 28-day treatment cycles. Participants randomised to IR will receive six 28-day cycles of rituximab, and ibrutinib taken daily for 6 years until minimal residual disease (MRD) negativity has been recorded for the same amount of time as it took to become MRD negative, or until disease progression. The primary endpoint is PFS according to the International Workshop on CLL (IWCLL) criteria. Secondary endpoints include: overall survival; proportion of participants with undetectable MRD; response to therapy by IWCLL criteria; safety and toxicity; health-related quality of life (QoL); and cost-effectiveness. Discussion The trial aims to provide evidence for the future first-line treatment of CLL patients by assessing whether IR is superior to FCR in terms of PFS, and whether toxicity rates are favourable. Trial registration ISRCTN01844152. Registered on 8 August 2014, EudraCT number 2013-001944-76. Registered on 26 April 2013

Resource use and direct medical costs of acute respiratory illness in the UK based on linked primary and secondary care records from 2001 to 2009

BackgroundPrevious studies have shown that influenza is associated with a substantial healthcare burden in the United Kingdom (UK), but more studies are needed to evaluate the resource use and direct medical costs of influenza in primary care and secondary care.MethodsA retrospective observational database study in the UK to describe the primary care and directly-associated secondary care resource use, and direct medical costs of acute respiratory illness (ARI), according to age, and risk status (NCT Number: 01521416). Patients with influenza, ARI or influenza-related respiratory infections during 9 consecutive pre-pandemic influenza peak seasons were identified by READ codes in the linked Clinical Practice Research Datalink (CPRD) and Hospital Episodes Statistics (HES) dataset. The study period was from 21st January 2001 to 31st March 2009.ResultsA total of 156,193 patients had ≥1 general practitioner (GP) episode of ARI, and a total of 82,204 patients received ≥1 GP prescription, at a mean of 2.5 (standard deviation [SD]: 3.0) prescriptions per patient. The total cost of GP consultations and prescriptions equated to £462,827 per year per 100,000 patients. The yearly cost of prescribed medication for ARI was £319,732, at an estimated cost of £11,596,350 per year extrapolated to the UK, with 40% attributable to antibiotics. The mean cost of hospital admissions equated to a yearly cost of £981,808 per 100,000 patients. The total mean direct medical cost of ARI over 9 influenza seasons was £21,343,445 (SD: £10,441,364), at £136.65 (SD: £66.85) per case.ConclusionsExtrapolating to the UK population, for pre-pandemic influenza seasons from 2001 to 2009, the direct medical cost of ARI equated to £86 million each year. More studies are needed to assess the costs of influenza disease to help guide public health decision-making for seasonal influenza in the UK

Age-related differences in integrin expression in peripheral blood lymphocytes

Alpha integrins play an important role in cell to cell and cell to extra-cellular matrix interactions required for an effective T-lymphocyte-mediated immune response, however little is known about age related differences in expression of alpha integrins on T-cells in humans. We here measured alpha-4 (α4) integrin (CD49d) expression on T-lymphocytes via peripheral blood sampling, comparing parameters between cohorts of young and old adults. No age-related differences were found for the absolute numbers of T-cells, although the percentage of CD4+ T-cells in older adults was significantly greater and the percentage of CD8+ T-cells lower than in younger cohorts. Percentage and absolute numbers of CD3+ T-cells co-expressing CD49d were significantly lower in older adults compared to younger cohorts, and the percentage of gated CD4+ and CD8+ cells that co-labelled positively for CD49d was also reduced in this group. There were no age-related differences in circulating levels of cytokines (Type I interferons) that are known to regulate cell surface integrin expression. Reduced expression of alpha integrins on T-cells may be an early indicator of the loss of homeostatic control that occurs with ageing, contributing to diminished effector T-cell responses during senescence

Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects

Inherited thrombocytopenias are a heterogeneous group of disorders characterised by abnormally low platelet counts which can be associated with abnormal bleeding. Next generation sequencing has previously been employed in these disorders for the confirmation of suspected genetic abnormalities, and more recently in the discovery of novel disease causing genes. However its full potential has not previously been utilised. Over the past 6 years we have sequenced the exomes from 55 patients, including 37 index cases and 18 additional family members, all of whom were recruited to the UK Genotyping and Phenotyping of Platelets study. All patients had inherited or sustained thrombocytopenia of unknown aetiology with platelet counts varying from 11-186x109 /L. Of the 51 patients phenotypically tested, 37 (73%), had an additional secondary qualitative platelet defect. Using whole exome sequencing analysis we have identified “pathogenic” or “likely pathogenic” variants in 46% (17/37) of our index patients with thrombocytopenia. In addition, we report variants of uncertain significance in 12 index cases which include novel candidate genetic variants in previously unreported genes in four index cases. These results demonstrate that whole exome sequencing is an efficient method for elucidating potential pathogenic genetic variants in inherited thrombocytopenia. Whole exome sequencing also has the added benefit of discovering potentially pathogenic genetic variants for further study in novel genes not previously implicated in inherited thrombocytopenia

Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk

Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia ris