Ligand conjugated liposomal drug delivery system for enhanced brain uptake of ampicillin

Targeting of antimicrobial agents by means of liposomes may be of great value in the treatment of intra or extracellular infections compare to conventional forms of antimicrobial therapy. In the present study Ampicillin loaded non-targeted Polyethylene glycolated liposomes and targeted Glutathione Polyethylene glycollated liposomes of about 132.14 nm size were prepared with 80 % of drug entrapment. Prepared liposomes were evaluated for in vitro, in vivo release profile and brain uptake studies. Results of these studies revealed more absorption of drug than standard Ampicillin solution and non targeted liposomes (Auc0-6h 1858.908 µg h/ml) and 3.5 times increase in brain uptake. Incorporation of polyethylene glycol in the liposomes increased the drug concentration and circulation time in plasma as well as in the extracellular fluid of brain thus improved therapeutic availability of Ampicillin trihydrate

Social media use in B2b sales and its impact on competitive intelligence collection and adaptive selling: Examining the role of learning orientation as an enabler

Highlights Findings of the study suggest that social media is one way to enhance sales performance, but its use alone does not guarantee such enhancement. Social media use will affect performance of salespeople through affecting their competitive intelligence collection and adaptive selling. Perceived usefulness of social media was not significantly related to salesperson social media use. Results support linking collection of competitive intelligence to a salesperson’s adaptive selling behavior. Abstract This paper examines the use of social media by business-to-business (B2B) salespeople to assist in their job functions. The authors propose that a salesperson\u27s attitude toward social media usefulness, as well as a salesperson\u27s learning orientation, will influence how much a salesperson uses social media to assist in day-to-day job tasks. Additionally, the impact that the use of social media has on collecting knowledge about competitors, adapting to customers, and sales performance is considered. Accordingly, a broad literature review is provided to introduce extant theory contributing to the proposed model. The practical uses of social media by salespeople will be described, and then the theoretical foundation is built, encompassing social media use, goal orientations, and adaptive selling theory. Results of an empirical model are provided, followed by a discussion of theoretical and managerial implications

Quantum information and precision measurement

We describe some applications of quantum information theory to the analysis of quantum limits on measurement sensitivity. A measurement of a weak force acting on a quantum system is a determination of a classical parameter appearing in the master equation that governs the evolution of the system; limitations on measurement accuracy arise because it is not possible to distinguish perfectly among the different possible values of this parameter. Tools developed in the study of quantum information and computation can be exploited to improve the precision of physics experiments; examples include superdense coding, fast database search, and the quantum Fourier transform.Comment: 13 pages, 1 figure, proof of conjecture adde

Salesperson moral identity and value co-creation

Purpose The purpose of this study is to examine the role of salesperson moral identity centrality in value co-creation. This study identified and tested an extended identity-based formation process of selling orientation, customer orientation and value co-creation. This was accomplished by examining the role of inclusion of others in the self and circle of moral regard in the mechanism through which moral identity centrality impacts selling orientation, customer orientation and value co-creation, taking into account the contingency role of salesperson self-construal. Design/methodology/approach An extended identity-behavior model grounded in identity theory and the social-cognitive perspective of moral identity centrality was tested. The study used survey data from business-to-business salespeople. Data collected was analyzed using structural equation modeling. Findings The results show that a central moral identity to a salesperson’s self-drives higher expansion of the salesperson’s circle of moral regard. This process facilitates the mechanisms for salesperson moral identity centrality to decrease selling orientation and increase customer orientation and value co-creation, leading to higher sales performance. Independent self-construal is found to deteriorate the positive effects of salesperson moral identity centrality on the inclusion of others in the self, expansion of the circle of moral regard and customer orientation. Research limitations/implications Through the conceptualized and tested framework, the study opens the door for additional research to inspect the role of moral identity centrality in sales. Practical implications Findings have implications for the human resource side of sales organizations in the areas of recruitment, mentoring, coaching and training. Moral identity centrality plays a vital role in the interface between salespeople and customers, leading to improved behavioral and sales outcomes. Sales managers must look for their salespeople’s moral identity centrality to improve morality in the attitudes and decision-making of their salesforce. Originality/value To the best of the authors’ knowledge, this study is the first to uncover the vital impacts of salesperson moral identity centrality on selling orientation, customer orientation and value co-creation. Through the conceptualized and tested framework, the study opens the door for additional research to inspect the role of moral identity centrality in sales

Validation of integrated pest management module against insect pests of pigeonpea, Cajanus cajan in Tarai region of Uttarakhand

Experiments on validation of integrated pest management (IPM) module against insect pest of pigeonpea in comparison with the Non-IPM (farmer’s practices) were conducted at N.E.B. Crop Research Centre, G. B. Pant University of Agriculture & Technology, Pantnagar during Kharif 2014 and 2015. Adopted IPM module contained Seed treatment with Trichoderma spp. @10g/kg of seed, Sole crop, Bird perches @ 50/ha, need based insecticides spray (Chlorantraniliprole 18.5SC @ 30 g a. i./ha; Neem soap@10g/lit; Acetamiprid 20SP @ 20 g a. i./ha). The results indicated that minimum population of pod borers (Helicoverpa armigera,Maruca vitrata and podfly) and sucking insects (aphids, jassids, pod bug) was reported in IPM plots and maximum population of insects was observed in Non-IPM plots. Percent insect control over non-IPM was 50.98 % for H. armigera, 44.69 % for M. vitrata and 19.17 % for Maruca webbing were recorded. While, for sucking pest complex, insect control over non-IPM was 51.59 %, 40.36 % and 36.17 % against jassids, aphids and tur pod bug, respectively. Similarly, minimum pod borer damage (6.48 and 7.71 %) was recorded in IPM plots as compared to maximum pod borer damage (8.37 and 8.22 %) in non-IPM plots, respectively during 2014 and 2015. Whereas, pooled grain yield for IPM plots was 1286.5 kg/ha for both seasons as against 888 kg/ha in non-IPM plots with 1:2.89 benefit cost ratio. Hence, It is apparent that studied IPM module was able to increase the yield of pigeonepea with lower cost of production as against non-IPM thus it would be benefiting the farmers