The Finslerian compact star model

We construct a toy model for compact stars based on the Finslerian structure of spacetime. By assuming a particular mass function, we find an exact solution of the Finsler-Einstein field equations with an anisotropic matter distribution. The solutions are revealed to be physically interesting and pertinent for the explanation of compact stars.Comment: Published in Eur.Phys.J.

Lyra's Cosmology of Massive String in Anisotropic Bianchi-II Space-time

The paper deals with a spatially homogeneous and totally anisotropic Bianchi II cosmological models representing massive strings in normal gauge for Lyra's manifold. The modified Einstein's field equations have been solved by applying variation law for Hubble's parameter. This law generates two type of solutions for average scale factor, one is of power law type and other is of exponential law type. The power law describes the dynamics of Universe from big bang to present epoch while exponential law seems reasonable to project dynamics of future Universe. It has been found that the displacement actor $(\beta)$ is a decreasing function of time and it approaches to small positive value at late time, which is collaborated with Halford (1970) as well as recent observations of SN Ia. The study reveals that massive strings dominate in early Universe and eventually disappear from Universe for sufficiently large time, which is in agreement with the current astronomical observations.Comment: 12 pages, 5 figure

Differential modulation of immune response and cytokine profiles in the bursae and spleen of chickens infected with very virulent infectious bursal disease virus

Background: Very virulent infectious bursal disease virus (vvIBDV) induces immunosuppression and inflammation in young birds, which subsequently leads to high mortality. In addition, infectious bursal disease (IBD) is one of the leading causes of vaccine failure on farms. Therefore, understanding the immunopathogenesis of IBDV in both the spleen and the bursae could help effective vaccine development. However, previous studies only profiled the differential expression of a limited number of cytokines, in either the spleen or the bursae of Fabricius of IBDV-infected chickens. Thus, this study aims to evaluate the in vitro and in vivo immunoregulatory effects of vvIBDV infection on macrophage-like cells, spleen and bursae of Fabricius. Results: The viral load was increased during the progression of the in vitro infection in the HD11 macrophage cell line and in vivo, but no significant difference was observed between the spleen and the bursae tissue. vvIBDV infection induced the expression of pro-inflammatory and Th1 cytokines, and chemokines from HD11 cells in a time- and dosage-dependent manner. Furthermore, alterations in the lymphocyte populations, cytokine and chemokine expression, were observed in the vvIBDV-infected spleens and bursae. A drastic rise was detected in numbers of macrophages and pro-inflammatory cytokine expression in the spleen, as early as 2 days post-infection (dpi). On 4 dpi, macrophage and T lymphocyte infiltration, associated with the peak expression of pro-inflammatory cytokines in the bursae tissues of infected chickens were observed. The majority of the significantly regulated pro-inflammatory cytokines and chemokines, in vvIBDV-infected spleens and bursae, were also detected in vvIBDV-infected HD11 cells. This cellular infiltration subsequently resulted in a sharp rise in nitric oxide (NO) and lipid peroxidation levels. Conclusion: This study suggests that macrophage may play an important role in regulating the early expression of pro-inflammatory cytokines, first in the spleen and then in the bursae, the latter tissue undergoing macrophage infiltration at 4 dpi

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

The Free Senior High Policy: An Appropriate Replacement to The Progressive Free Senior High Policy

Governments all over the world have been improving their educational sector through funding programs aimed at reducing the financial burden on parents, increasing access and quality to education. The government of Ghana in 2017 switched policy to a free senior high school policy to reduce poverty by finally eliminating the financial burdens parents face in paying their children’s fees. This study seeks to evaluate the appropriateness of the free senior high policy in replacing the pre-existing progressive free policy. The questionnaire survey was used to collect primary data for this study. The descriptive statistics were used in analyzing the data of this study. A total number of Two hundred (200) responses were retrieved, and out of those retrieved, 57 were females, and 143 were males. All 200 responses were usable in this study. The free senior high policy proved to put more butts on seats in helping to reduce financial burdens on parents than the pre-existing progressive free policy since nothing is paid by parents or guardians

Land Suitability Evaluation of Tea (<i>Camellia sinensis</i> L.) Plantation in Kallar Watershed of Nilgiri Bioreserve, India

Nilgiri tea is a vital perennial beverage variety and is in high demand in global markets due to its quality and medicinal value. In recent years, the cultivation of tea plantations has decreased due to the extreme climate and prolonged practice of tea cultivation in the same area, decreasing its taste and quality. In this scenario, land suitability analysis is the best approach to evaluate the bio-physiochemical and ecological parameters of tea plantations. The present study aims to identify and delineate appropriate land best suited for the cultivation of tea within the Kallar watershed using the geographic information system (GIS) and multi-criteria evaluation (MCE) techniques. This study utilises various suitability criteria, such as soil (texture, hydrogen ion concentration, electrical conductivity, depth, base saturation, and drainability), climate (rainfall and temperature), topography (relief and slope), land use, and the normalised difference vegetation index (NDVI), to evaluate the suitability of the land for growing tea plantations based on the Food and Agricultural Organization (FAO) guidelines for rainfed agriculture. The resultant layers were classified into five suitability classes, including high (S1), moderate (S2), and marginal (S3) classes, which occupied 16.7%, 7.08%, and 16.3% of the land, whereas the currently and permanently not suitable (N1 and N2) classes covered about 18.52% and 29.06% of the total geographic area. This study provides sufficient insights to decision-makers and farmers to support them in making more practical and scientific decisions regarding the cultivation of tea plantations that will result in the increased production of quality tea, and prevent and protect human life from harmful diseases

Natural And Human-Induced Land Degradation And Its Impact Using Geospatial Approach In The Kallar Watershed Of Tamil Nadu, India

Land degradation is human-induced and natural process that adversely affects the land, to function effectively within a complex ecosystem. In recent years, the Kallar watershed has encountered various kinds of multifarious problems on both land and water in the urban and its environs. The upper part of the study area is facing water scarcity problems in the past few years, but which included no such rare occurrences in the past. The mid-portion in the vicinity of foothills are highly affected by soil erosion, whereas the lower portion of the area has faced problems like land degradation, such as an unusual increase of wastelands and conversion of good agriculture lands into construction plots. Apart from these, the study area is frequently affected by nature induced disasters like a landslide, forest fire, flooding, and drought. In this complex situation, the qualitative assessment of human-induced land degradation and its impact is essential. For this, Geospatialbased Multi-Criteria Evaluation (MCE) as a multidisciplinary approach has been adopted. To assess land degradation, six major criterions are preferred such as terrain (slope, elevation), environment (landuse/land cover, NDVI), soil erosion, and demography (population density). Considerable weights and ranks were assigned through an empirical MCE method. Based on the criteria, the land degradation was carefully delineated into five significant categories such as low (38.3%), moderately (23.6%), marginally (15.4%), highly (4.8%), and severely degraded (17.8%). The depletion of vegetation cover on hilly terrain and subsequent cultivation without proper protection measures constitute the possible reason for severe soil erosion and land degradation

ESTIMATION OF ANNUAL AVERAGE SOIL LOSS, BASED ON RUSLE MODEL IN KALLAR WATERSHED, BHAVANI BASIN, TAMIL NADU, INDIA

Soil erosion is a widespread environmental challenge faced in Kallar watershed nowadays. Erosion is defined as the movement of soil by water and wind, and it occurs in Kallar watershed under a wide range of land uses. Erosion by water can be dramatic during storm events, resulting in wash-outs and gullies. It can also be insidious, occurring as sheet and rill erosion during heavy rains. Most of the soil lost by water erosion is by the processes of sheet and rill erosion. Land degradation and subsequent soil erosion and sedimentation play a significant role in impairing water resources within sub watersheds, watersheds and basins. Using conventional methods to assess soil erosion risk is expensive and time consuming. A comprehensive methodology that integrates Remote sensing and Geographic Information Systems (GIS), coupled with the use of an empirical model (Revised Universal Soil Loss Equation- RUSLE) to assess risk, can identify and assess soil erosion potential and estimate the value of soil loss. GIS data layers including, rainfall erosivity (R), soil erodability (K), slope length and steepness (LS), cover management (C) and conservation practice (P) factors were computed to determine their effects on average annual soil loss in the study area. The final map of annual soil erosion shows a maximum soil loss of 398.58 t/ h-1/ y-1. Based on the result soil erosion was classified in to soil erosion severity map with five classes, very low, low, moderate, high and critical respectively. Further RUSLE factors has been broken into two categories, soil erosion susceptibility (A=RKLS), and soil erosion hazard (A=RKLSCP) have been computed. It is understood that functions of C and P are factors that can be controlled and thus can greatly reduce soil loss through management and conservational measures