366 research outputs found
Equivariant comparison of quantum homogeneous spaces
We prove the deformation invariance of the quantum homogeneous spaces of the
q-deformation of simply connected simple compact Lie groups over the
Poisson-Lie quantum subgroups, in the equivariant KK-theory with respect to the
translation action by maximal tori. This extends a result of Neshveyev-Tuset to
the equivariant setting. As applications, we prove the ring isomorphism of the
K-group of Gq with respect to the coproduct of C(Gq), and an analogue of the
Borsuk-Ulam theorem for quantum spheres.Comment: 21 page
A Characterization of right coideals of quotient type and its application to classification of Poisson boundaries
Let be a co-amenable compact quantum group. We show that a right coideal
of is of quotient type if and only if it is the range of a conditional
expectation preserving the Haar state and is globally invariant under the left
action of the dual discrete quantum group. We apply this result to theory of
Poisson boundaries introduced by Izumi for discrete quantum groups and
generalize a work of Izumi-Neshveyev-Tuset on for co-amenable compact
quantum groups with the commutative fusion rules. More precisely, we prove that
the Poisson integral is an isomorphism between the Poisson boundary and the
right coideal of quotient type by maximal quantum subgroup of Kac type. In
particular, the Poisson boundary and the quantum flag manifold are isomorphic
for any q-deformed classical compact Lie group.Comment: 28 pages, Remark 4.9 adde
The K-theory of free quantum groups
In this paper we study the K -theory of free quantum groups in the sense of Wang and Van Daele, more precisely, of free products of free unitary and free orthogonal quantum groups. We show that these quantum groups are K -amenable and establish an analogue of the Pimsner–Voiculescu exact sequence. As a consequence, we obtain in particular an explicit computation of the K -theory of free quantum groups. Our approach relies on a generalization of methods from the Baum–Connes conjecture to the framework of discrete quantum groups. This is based on the categorical reformulation of the Baum–Connes conjecture developed by Meyer and Nest. As a main result we show that free quantum groups have a γ -element and that γ=1 . As an important ingredient in the proof we adapt the Dirac-dual Dirac method for groups acting on trees to the quantum case. We use this to extend some permanence properties of the Baum–Connes conjecture to our setting
Classification of minimal actions of a compact Kac algebra with amenable dual
We show the uniqueness of minimal actions of a compact Kac algebra with
amenable dual on the AFD factor of type II. This particularly implies the
uniqueness of minimal actions of a compact group. Our main tools are a Rohlin
type theorem, the 2-cohomology vanishing theorem, and the Evans-Kishimoto type
intertwining argument.Comment: 68 pages, Introduction rewritten; minor correction
Myosteatosis predicts survival after surgery for periampullary cancer::a novel method using MRI
Background: Myosteatosis, characterized by inter-and intramyocellular fat deposition, is strongly related to poor overall survival after surgery for periampullary cancer. It is commonly assessed by calculating the muscle radiation attenuation on computed tomography (CT) scans. However, since magnetic resonance imaging (MRI) is replacing CT in routine diagnostic work-up, developing methods based on MRI is important. We developed a new method using MRI-muscle signal intensity to assess myosteatosis and compared it with CT-muscle radiation attenuation.Methods: Patients were selected from a prospective cohort of 236 surgical patients with periampullary cancer. The MRI-muscle signal intensity and CT-muscle radiation attenuation were assessed at the level of the third lumbar vertebra and related to survival.Results: Forty-seven patients were included in the study. Inter-observer variability for MRI assessment was low (R-2 = 0.94). MRI-muscle signal intensity was associated with short survival: median survival 9.8 (95%-CI: 1.5-18.1) vs. 18.2 (95%-CI: 10.7-25.8) months for high vs. low intensity, respectively (p = 0.038). Similar results were found for CT-muscle radiation attenuation (low vs. high radiation attenuation: 10.8 (95%-CI: 8.5-13.1) vs. 15.9 (95%-CI: 10.2-21.7) months, respectively; p = 0.046). MRI-signal intensity correlated negatively with CT-radiation attenuation (r=-0.614, p <0.001).Conclusions: Myosteatosis may be adequately assessed using either MRI-muscle signal intensity or CT-muscle radiation attenuation.</p
Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3in vivo
Background
Although much is known about the regulation of osteoclast (OC) formation and activity, little is known about OC senescence. In particular, the fate of of OC seen after 1,25-(OH)2D3 administration in vivo is unclear. There is evidence that the normal fate of OC is to undergo apoptosis (programmed cell death). We have investigated the effect of short-term application of high dose 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on OC apoptosis in an experimental rat model.
Methods
OC recruitment, augmentation and apoptosis was visualised and quantitated by staining histochemically for tartrate resistant acid phosphatase (TRAP), double staining for TRAP/ED1 or TRAP/DAPI, in situ DNA fragmentation end labelling and histomorphometric analysis.
Results
Short-term treatment with high-dose 1,25-(OH)2D3 increased the recruitment of OC precursors in the bone marrow resulting in a short-lived increase in OC numbers. This was rapidly followed by an increase in the number of apoptotic OC and their subsequent removal. The response of OC to 1,25-(OH)2D3 treatment was dose and site dependent; higher doses producing stronger, more rapid responses and the response in the tibiae being consistently stronger and more rapid than in the vertebrae.
Conclusions
This study demonstrates that (1) after recruitment, OC are removed from the resorption site by apoptosis (2) the combined use of TRAP and ED1 can be used to identify OC and their precursors in vivo (3) double staining for TRAP and DAPI or in situ DNA fragmentation end labelling can be used to identify apoptotic OC in vivo
Folate catabolites in spot urine as non-invasive biomarkers of folate status during habitual intake and folic acid supplementation.
Folate status, as reflected by red blood cell (RCF) and plasma folates (PF), is related to health and disease risk. Folate degradation products para-aminobenzoylglutamate (pABG) and para-acetamidobenzoylglutamate (apABG) in 24 hour urine have recently been shown to correlate with blood folate.
Since blood sampling and collection of 24 hour urine are cumbersome, we investigated whether the determination of urinary folate catabolites in fasted spot urine is a suitable non-invasive biomarker for folate status in subjects before and during folic acid supplementation.
Immediate effects of oral folic acid bolus intake on urinary folate catabolites were assessed in a short-term pre-study. In the main study we included 53 healthy men. Of these, 29 were selected for a 12 week folic acid supplementation (400 µg). Blood, 24 hour and spot urine were collected at baseline and after 6 and 12 weeks and PF, RCF, urinary apABG and pABG were determined.
Intake of a 400 µg folic acid bolus resulted in immediate increase of urinary catabolites. In the main study pABG and apABG concentrations in spot urine correlated well with their excretion in 24 hour urine. In healthy men consuming habitual diet, pABG showed closer correlation with PF (rs = 0.676) and RCF (rs = 0.649) than apABG (rs = 0.264, ns and 0.543). Supplementation led to significantly increased folate in plasma and red cells as well as elevated urinary folate catabolites, while only pABG correlated significantly with PF (rs = 0.574) after 12 weeks.
Quantification of folate catabolites in fasted spot urine seems suitable as a non-invasive alternative to blood or 24 hour urine analysis for evaluation of folate status in populations consuming habitual diet. In non-steady-state conditions (folic acid supplementation) correlations between folate marker (RCF, PF, urinary catabolites) decrease due to differing kinetics
Constructing the extended Haagerup planar algebra
We construct a new subfactor planar algebra, and as a corollary a new
subfactor, with the `extended Haagerup' principal graph pair. This completes
the classification of irreducible amenable subfactors with index in the range
, which was initiated by Haagerup in 1993. We prove that the
subfactor planar algebra with these principal graphs is unique. We give a skein
theoretic description, and a description as a subalgebra generated by a certain
element in the graph planar algebra of its principal graph. In the skein
theoretic description there is an explicit algorithm for evaluating closed
diagrams. This evaluation algorithm is unusual because intermediate steps may
increase the number of generators in a diagram.Comment: 45 pages (final version; improved introduction
Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies
Background: In non-randomized studies (NRSs) where a continuous outcome variable (e.g., depressive symptoms) is assessed at baseline and follow-up, it is common to observe imbalance of the baseline values between the treatment/exposure group and control group. This may bias the study and consequently a meta-analysis (MA) estimate. These estimates may differ across statistical methods used to deal with this issue. Analysis of individual participant data (IPD) allows standardization of methods across studies. We aimed to identify methods used in published IPD-MAs of NRSs for continuous outcomes, and to compare different methods to account for baseline values of outcome variables in IPD-MA of NRSs using two empirical examples from the Thyroid Studies Collaboration (TSC). Methods: For the first aim we systematically searched in MEDLINE, EMBASE, and Cochrane from inception to February 2021 to identify published IPD-MAs of NRSs that adjusted for baseline outcome measures in the analysis of continuous outcomes. For the second aim, we applied analysis of covariance (ANCOVA), change score, propensity score and the naïve approach (ignores the baseline outcome data) in IPD-MA from NRSs on the association between subclinical hyperthyroidism and depressive symptoms and renal function. We estimated the study and meta-analytic mean difference (MD) and relative standard error (SE). We used both fixed- and random-effects MA. Results: Ten of 18 (56%) of the included studies used the change score method, seven (39%) studies used ANCOVA and one the propensity score (5%). The study estimates were similar across the methods in studies in which groups were balanced at baseline with regard to outcome variables but differed in studies with baseline imbalance. In our empirical examples, ANCOVA and change score showed study results on the same direction, not the propensity score. In our applications, ANCOVA provided more precise estimates, both at study and meta-analytical level, in comparison to other methods. Heterogeneity was higher when change score was used as outcome, moderate for ANCOVA and null with the propensity score. Conclusion: ANCOVA provided the most precise estimates at both study and meta-analytic level and thus seems preferable in the meta-analysis of IPD from non-randomized studies. For the studies that were well-balanced between groups, change score, and ANCOVA performed similarly
Fatigue in patients with chronic disease:results from the population-based Lifelines Cohort Study
(1) To evaluate the prevalence of severe and chronic fatigue in subjects with and without chronic disease; (2) to assess to which extent multi-morbidity contributes to severe and chronic fatigue; and (3) to identify predisposing and associated factors for severe and chronic fatigue and whether these are disease-specific, trans-diagnostic, or generic. The Dutch Lifelines cohort was used, including 78,363 subjects with (n = 31,039, 53 ± 12 years, 33% male) and without (n = 47,324, 48 ± 12 years, 46% male) ≥ 1 of 23 chronic diseases. Fatigue was assessed with the Checklist Individual Strength-Fatigue. Compared to participants without a chronic disease, a higher proportion of participants with ≥ 1 chronic disease were severely (23% versus 15%, p < 0.001) and chronically (17% versus 10%, p < 0.001) fatigued. The odds of having severe fatigue (OR [95% CI]) increased from 1.6 [1.5–1.7] with one chronic disease to 5.5 [4.5–6.7] with four chronic diseases; for chronic fatigue from 1.5 [1.5–1.6] to 4.9 [3.9–6.1]. Multiple trans-diagnostic predisposing and associated factors of fatigue were found, explaining 26% of variance in fatigue in chronic disease. Severe and chronic fatigue are highly prevalent in chronic diseases. Multi-morbidity increases the odds of having severe and chronic fatigue. Several trans-diagnostic factors were associated with fatigue, providing a rationale for a trans-diagnostic approach
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