From the perspective of existential communication and feminist paradigm

This work is focused on the thought that the nature of communication between a father and his daughter influences how that woman will perceive her identity. It is known that a person's perception of his own identity affects his attitude. A person who has a positive perception of identity can realize himself by reaching his reality, while it is thought that a person with a negative and non-constructive perception of identity will experience difficulties in reaching his reality. The objective of this thesis is to review father-daughter communication and attain its effects on how a woman perceives her identity. Father-daughter communication will be discussed based on the Existential Communication concept of the existential philosopher Karl Jaspers, who puts communication at the core of his philosophy. Semi-structured in-depth interviews were conducted with seven female participants who were identified by applying the snowball sampling recruitment technique. During the interviews, the participants were asked questions about their communication with their father. Records of the interviews were analyzed and resolved with the thick description method. The participant data obtained from the in-depth interviews was reviewed in the context of the Existential Communication concept and the findings include results that support the hypothesis of this master thesis work

Social norms regarding alcohol use and associated factors among university students in Turkey

Background: Misperceptions on the higher rates of peer alcohol use are predictive of increased personal use among university students. Objectives: This study aims to assess the prevalence, perceived peers’ social norms and other predictors of alcohol use in a sample of Turkish university students. Methods: This study is established upon the baseline Turkish data on alcohol use of the project Social Norms Intervention for the prevention of Polydrug usE (SNIPE). The data was obtained by a self-reported, online questionnaire from 858 students of Marmara University who were registered to the study web page. Results: Alcohol use and drunkenness rates were 62.6%, and 40.9%, respectively. Twenty point two percent of students reported drinking alcohol at least once a week in the last two months. Majority of students (70.4%) reported that religion has an important or very important role in their lives. Perceived higher frequency of peer alcohol use (p<0.000) and drunkenness (p<0.000) were significantly associated with personal alcohol use frequency. Tobacco use rate was 60.2% and positively associated with alcohol use frequency (p<0.000). In all participants, male gender (OR: 1.56; 95% CI: 1.07-2.28), giving less importance to religion (OR: 20.91; 95% CI: 10.95-39.95), tobacco use everyday/almost everyday (OR: 17.88; 95% CI: 9.33-34.29), perceived positive peer attitude towards alcohol use (OR: 2.192; 95% CI: 1.25-3.82) and perceived higher frequency of peer alcohol use (OR: 3.487; 95% CI: 1.66-7.31) were found to be associated risk factors for alcohol use. Age (OR: 1.186, CI 95%: 1.03-1.36) and perceived positive peer attitude towards alcohol use (OR: 3.86, CI 95%: 1.84-8.09) were the additional risk factors among female student whereas perceived positive peer alcohol use frequency (OR: 8.08, CI 95%: 2.40-27.10) among male students. Discussion: As the first study conducted in Turkey applying social norms theory, our results indicate the noticeable misperceptions of students regarding their peers’ alcohol use. Based on our results, targeting both tobacco and alcohol use, and a gender-sensitive approach employing social norms interventions may enhance the preventive strategies for risky alcohol use among university students

20 years on: The legacy of Daksha Emson for perinatal psychiatry

The tragedy of Daksha’s death illustrates both the importance of perinatal mental health and the stigma associated with doctors seeking help. With this letter, we express our hope that the lasting legacy of her and others’ tragic stories lies in the continuing improvement and worldwide expansion of perinatal psychiatric services and training so that those in greatest need receive the best care possible wherever — and whoever — they are

Attitudes toward COVID-19 pandemic measures and clinical symptom severity in schizophrenia patients: a preliminary cross-sectional study

Objectives The study aim was to compare clinical symptom severity and quality of life (QoL) among schizophrenia patients according to their attitudes toward pandemic measures and reported lockdown-related disruption. Methods Patients with schizophrenia attending follow-up sessions at two community mental health centers were included in this cross-sectional study. Sociodemographic and clinical characteristics of patients were assessed using a standardized form and the following psychometric instruments: the Positive and Negative Syndrome Scale, Brief Psychiatric Rating Scale, State-Trait Anxiety Inventory, Heinrich–Carpenter Quality of Life Scale and Clinical Global Impressions Ratings-Severity scale. Patients were grouped according to their attitudes toward pandemic measures (positive attitudes or non-positive attitudes). Results No significant differences were found in sociodemographic and clinical variables, clinical symptom severity or QoL between schizophrenia patients with positive attitudes and those without positive attitudes toward pandemic measures. Guilt feelings and trait anxiety levels were positively related to lockdown-related disruption. Conclusions Positive attitudes toward pandemic measures may be affected by factors other than the sociodemographic and clinical status of schizophrenia patients. It is important that such factors are assessed in future studies to better manage pandemic-related challenges among schizophrenia patients

A transcriptome based approach to predict candidate drug targets and drugs for Parkinson's disease using an in vitro 6-OHDA model

The most common treatment strategies for Parkinson's disease (PD) aim to slow down the neurodegeneration process or control the symptoms. In this study, using an in vitro PD model we carried out a transcriptome-based drug target prediction strategy. We identified novel drug target candidates by mapping genes upregulated in 6-OHDA-treated cells on a human protein-protein interaction network. Among the predicted targets, we show that AKR1C3 and CEBPB are promising in validating our bioinformatics approach since their known ligands, rutin and quercetin, respectively, act as neuroprotective drugs that effectively decrease cell death, and restore the expression profiles of key genes upregulated in 6-OHDA-treated cells. We also show that these two genes upregulated in our in vitro PD model are downregulated to basal levels upon drug administration. As a further validation of our methodology, we further confirm that the potential target genes identified with our bioinformatics approach are also upregulated in post-mortem transcriptome samples of PD patients from the literature. Therefore, we propose that this methodology predicts novel drug targets AKR1C3 and CEBPB, which are relevant to future clinical applications as potential drug repurposing targets for PD. Our systems-based computational approach to predict candidate drug targets can be employed in identifying novel drug targets in other diseases without a priori assumption

Sebahattin Tarkan Özçetin ve Türkiye'nin ilk kedi hastanesi

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2017.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Özer, Abdürrahim

Validation of an In-Vitro Parkinson’s Disease Model for the Study of Neuroprotection

Parkinson’s disease (PD) is the second most common neurodegenerative disease with an estimation of 10 million people living with the disease and it is increasing in prevalence every year. Familial cases of PD are source of valuable information to determine genetical risk factors yet sporadic cases can emerge from distinct mechanisms so, identifying common pathways of familial and sporadic cases of PD may provide worthwhile insights to determine underlying mechanisms through the progression. LRRK2 mutations are the most common indicators of both sporadic and familial cases of PD and α-synuclein aggregation is one of the hallmarks of both cases of PD as well as in other synucleinopathies. As in the case of most neurological diseases, human studies addressing the molecular basis of pathology are generally restricted to post-mortem materials. For this reason, cell culture systems and animal models are widely used. There are two main approaches for modelling PD: genetically constructed PD models and neuroxin-based models. In this study, we aim to construct and compare both approaches by overexpressing wild-type (WT) and A53T mutant α-synuclein and treating cells with well-known neurotoxin 6-hydroxidopamine (6-OHDA) using dopaminergic human neuroblastoma SH-SY5Y cell line. Our findings suggest that WT or A53T α-synuclein overexpression by itself is not sufficient to cause significant toxicity in SH-SY5Y cells in the presented time scale. As expected, 6-OHDA treatment caused toxicity with an IC50 value of ~100 µM. In addition, 6-OHDA treatment causes 3- and 2.5-fold increase in SNCA and LRRK2 expression respectively

Psychiatric training in perinatal mental health across Europe

Perinatal mental illness is associated with considerable maternal and infant morbidity and mortality. However, there are currently no specific guidelines on the standards and structure of postgraduate perinatal psychiatric training in Europe. We describe the characteristics of available and desired specialist perinatal psychiatry training from the perspective of European psychiatrists in training. An online survey was conducted among 34 national psychiatric trainee association representatives of the European Federation of Psychiatric Trainees (EFPT). Participants from the countries in which perinatal psychiatry training was available were invited to participate in in-depth follow-up interviews. Six countries out of 34 (18%) reported that specialist training in perinatal mental health was available (Finland, France, Germany, Ireland, Malta, and the UK). The nature of available training varied in duration, the supervision and assessment model employed, and the training scheme context. Of the 28 countries where specialist perinatal psychiatry training was unavailable, the majority of national representatives (22 countries, 76%) wanted specialist perinatal psychiatry training to be included in their national training curricula. There is a gap between the expected skills and the available training for psychiatrists to meet the mental healthcare needs of women in the perinatal period. Given the prevalence and impact of perinatal mental illness and the expressed desires of trainees themselves for specialist training, this finding should prompt urgent action. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00737-022-01216-w

Severe mental illness and European COVID-19 vaccination strategies

The EU advises prioritising vaccination for people whose health makes them particularly at risk for severe COVID-19, but leaves it to member states to decide which medical conditions get prioritised. Ethical, neuroscientific, and public health considerations have been used to prioritise individuals with severe mental illness (ie, psychotic disorders, bipolar disorders, and severe major depressive disorders).1, 2, 3 We systematically reviewed national COVID-19 vaccine deployment plans across 20 European countri

Sustainable Urbanism: Envisioning New Agents for Planning and Designing Sustainable Spaces

Sustainable urbanism studies cities, their parts and urbanisation practices to promote their long-term viability and liveability by reducing consumption, waste and harmful impacts on people, places, and environment, and to enhance the physical, ecological, economic, social well-being, health, and equity of people, places and environment. It turns into practice through planning, design and engineering, while at the same time, caring about the sustainability of natural environment and ecosystems, and social, economic and cultural aspects of urbanism. Additionally, sustainable urbanism is related to the process of constructing sustainable buildings and developing the planning and design strategies for smart urban growth management. Within this perspective, Sustainable Urbanism: Envisioning New Agents for Planning and Designing Sustainable Spaces aims to investigate how sustainability of urban and rural spaces can be attained with multi-scalar, multi-dimensional and multi-stakeholders viewpoints. Also, it seeks to explore new ways of living and developing sustainable urban and rural systems and practices, i.e. sustainable living, working, making public and private spaces by integrating sustainable tourism, conservation and regeneration of spaces. Employing an agent-based design approach, this book shows how these aims and attempts can be achieved by planning and design of urban and rural space. The research and design team of the book from Middle East Technical University (Master of Urban Design) seek to learn, think about and find the ways and possibilities to develop and sometimes invent the tools to attain a higher degree of sustainability via urban design research and projects on Göreme in Cappadocia that is a small but a very precious and inspiring town in Turkey with its fascinating urban, historical and cultural heritage and natural landscape