Interaction of diesel engine soot with NO2 and O2 at diesel exhaust conditions. Effect of fuel and engine operation mode

This work shows a study of the reactivity of twelve different types of soot with either NO2 or O2 under reacting conditions typically present in diesel particulate filters (DPFs). The soot samples were obtained from the combustion of four conventional and alternative fuels (diesel, biodiesel and two paraffinic fuels) in a diesel engine bench operated under three different engine operation modes: a typical urban-driving mode and two variations to this mode to assess the effect of the injection settings. The main objective of the work is to relate the oxidative reactivity of the soot to the nature and the origin of each sample. The possible simultaneous elimination of soot and NOx at typical diesel exhaust conditions is examined, as well. The reactivity tests were performed in a laboratory quartz gas flow reactor, discontinuous for the solid. The soot-NO2 interaction was studied with 200 ppm of NO2 at 500 °C and the soot-O2 interaction was studied with 5% O2 at 500 °C and 600 °C. The experimental results were used to determine the time needed for the complete conversion of carbon (t) through the use of the equations of the Shrinking Core Model for solid-gas reactions with decreasing size particle and chemical reaction control. In general, the t values show that the diesel fuel generates a less reactive soot than biodiesel or the alternative paraffinic fuels. In addition, increasing the injection pressure or adding a post-injection to the original injection strategy generates a more reactive soot. These findings point out that there is potential to achieve efficient regeneration processes in DPFs through other fuels than conventional ones and via engine calibration

Endocannabinoid regulation of amyloid-induced neuroinflammation

The modulation of endocannabinoid (EC) levels and the activation of cannabinoid receptors are seen as promising therapeutic strategies in a variety of diseases, including Alzheimer’s disease (AD). We aimed to evaluate the effect of the pharmacological and genetic inhibiton of anandamide (AEA)-degrading enzyme in a mouse model of AD (5xFAD). Pharmacological inhibition of the fatty acid amide hydrolase (FAAH) had little impact on the expression of key enzymes and cytokines as well as on the cognitive impairment and plaque deposition and gliosis in 5xFAD mice. CB1 blockade exacerbated inflammation in this transgenic mouse model of AD. The genetic inactivation of FAAH led to increases in the expression of inflammatory cytokines. At the same time, FAAH-null 5xFAD mice exhibited a behavioral improvement in spatial memory that was independent of the level of anxiety and was not CB1-mediated. Finally, mice lacking FAAH showed diminished soluble amyloid levels, neuritic plaques and gliosis. These data reinforce the notion of a role for the endocannabinoid system in neuroinflammation and open new perspectives on the relevance of modulating endocannabinoid levels in the inflammed brain.pre-print687 K

Study I. PhD project

Data derived from the PhD project.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Simultaneous detection of two breast cancer-related miRNAs in tumor tissues using p19-based disposable amperometric magnetobiosensing platforms

Los resultados derivados de esta investigación fueron empleados por la Oficina de Transferencia de Resultados de Investigación de la UCM para la elaboración de una noticia con título: 'Un biosensor magnético detecta el cáncer de mama más agresivo'. Además, este artículo fue resaltado en numerosos sitios web, poniendo de manifiesto su indiscutible relevancia. Algunos de los sitios en los que la noticia fue publicaba se incluyen a continuación: https://www.agenciasinc.es/Noticias/Un-biosensor-magnetico-detecta-el-cancer-de-mama-mas-agresivo https://revistalvr.es/un-biosensor-magnetico-detecta-el-cancer-de-mama-mas-agresivo/ https://www.biotechmagazine.es/noticias-biotech/biosensor-magnetico-frente-al-cancer-de-mama/ https://www.infosalus.com/asistencia/noticia-biosensor-detectar-cancer-mama-mas-agresivo-made-in-spain-20150422183529.html https://www.rtve.es/noticias/20150422/biosensor-magnetico-detecta-cancer-mama-mas-agresivo-solo-15-minutos/1134380.shtml https://www.bolsamania.com/noticias/sanidad/disenan-un-biosensor-magnetico-capaz-de-detectar-precozmente-el-cancer-de-mama-mas-agresivo--699233.html http://biotech-spain.com/en/articles/un-biosensor-magn-tico-detecta-el-c-ncer-de-mama-m-s-agresivo/A novel magnetobiosensing approach for the rapid and simultaneous detection of two breast cancer-related miRs (miR-21 and miR-205) is reported. It involves the use of antimiR-21 and antimiR-205 specific probes, chitin-modified magnetic beads (Chitin-MBs), the p19 viral protein as capture bioreceptor and amperometric detection with the H2O2/hydroquinone (HQ) system at dual screen-printed carbon electrodes (SPdCEs). The use of SPdCEs allows the simultaneous independent amperometric readout for each target miR to be measured. The magnetosensor exhibited sensitive and selective detection with dynamic ranges from 2.0 to 10.0nM and detection limits of 0.6nM (6fmol) for both target miRs without any amplification step in less than 2h. The usefulness of the approach was evaluated by detecting the endogenous levels of both target miRs in total RNA (RNAt) extracted from metastatic breast cancer cell lines and human tissues.Spanish Ministerio de Ciencia e InnovaciónSpanish Ministeri de Economía y CompetitividadComunidad de MadridEuropean CommissionSpanish Ministry of EducationDepto. de Química AnalíticaFac. de Ciencias QuímicasTRUEpu

Automation and optimization device for the fabrication of sensors with nanomaterials

2021 13th Spanish Conference on Electron Devices, 9-11 june, Sevilla, Spain 3 páginas, 7 figurasThis work presents a device, “dropcaster”, developed to automate and optimize the deposition process of the sensitive layer of gas sensors using the drop–casting technique. It is designed to development sensors in the research phase of different materials and the study of their behavior and response to different gaseous compounds.This research was funded by Department of Education and Research of the Madrid Autonomous Community (Spain) grant number IND2017/TIC7714. Pristine graphene was supplied by ENEA (Portici, Italy)