Old age pensions and retirement in Spain

In this paper we analyze the influence that incentives play in the timing of the transition to retirement in Spain. We use the Continuous Sample of Working Histories 2006 (CSWH 'Muestra Continua de Vidas Laborales', in Spanish) to construct incentive measures from the Social Security provisions in relation to retiring at old age. We analyse the role played by such incentives and other socio-economic variables on the retirement hazard of men aged between 60 and 70, using a duration model to carry out a dynamic analysis. We assess the effects of the pension system reform that took place in 2002, which set stricter conditions to access an old pension. The results show that both the pension wealth and the substitution effects play a significant role in retirement decisions, but that, after the reform, the latter effects become less important

Psychometric Testing of the Spanish Modified Version of the Mini-Suffering State Examination

Background: The mini-suffering state examination is a valid and reliable measure that have been used to assess suffering in patients with advanced cancer. The aim of this study was to carry out a psychometric analysis of the Spanish version of the mini-suffering state examination. Method: A validation study was conducted. Seventy-two informal caregivers of deceased patients in palliative care were included in this study. A psychometric testing of content validity, internal consistency, and convergent validity with the Spanish version of the quality of dying and death questionnaire was performed. Results: The original instrument was modified to be used by informal caregivers. The content validity was acceptable (0.96), and the internal consistency was moderate (α = 0.67). Convergent validity was demonstrated (r = −0.64). Conclusion: The Spanish modified version of the MSSE showed satisfactory measurement properties. The Spanish modified version of MSSE can be useful to facilitate screening, monitor progress, and guide treatment decisions in end-of-life cancer patients

Prognostic value of replication errors on chromosomes 2p and 3p in non-small-cell lung cancer

As chromosomes 2p and 3p are frequent targets for genomic instability in lung cancer, we have addressed whether alterations of simple (CA)n DNA repeats occur in non-small-cell lung cancer (NSCLC) at early stages. We have analysed by polymerase chain reaction (PCR) assay replication errors (RER) and loss of heterozygosity (LOH) at microsatellites mapped on chromosomes 2p and 3p in 64 paired tumour-normal DNA samples from consecutively resected stage I, II or IIIA NSCLC. DNA samples were also examined for K-ras and p53 gene mutations by PCR-single-stranded conformational polymorphism (PCR-SSCP) analysis and cyclic sequencing, as well as their relationship with clinical outcome. Forty-two of the 64 (66%) NSCLC patients showed RER at single or multiple loci. LOH was detected in 23 tumours (36%). Among patients with stage I disease, the 5-year survival rate was 80% in those whose tumours had no evidence of RER and 26% in those with RER (P = 0.005). No correlation was established between RER phenotype and LOH, K-ras or p53 mutations. RER remained a strong predictive factor (hazard ratio for death, 2.89; 95% confidence interval, 2.23-3.79; P = 0.002) after adjustment for all other evaluated factors, including p53, K-ras, LOH, histological type, tumour differentiation and TNM stage, suggesting that microsatellite instability on chromosomes 2p and 3p may play a role in NSCLC progression through a different pathway from the traditional tumour mechanisms of oncogene activation and/or tumour-suppressor gene inactivation

Software Process Dynamics: Modeling, Simulation and Improvement

The aim of this chapter is to introduce the reader to the dynamics of the software process, the ways to represent and formalize it, and how it can be integrated with other techniques to facilitate, among other things, process improvement. In order to achieve this goal, different approaches of software process modeling and simulation will be introduced, analyzing their pros and cons. Then, continuous modeling will be used as the modeling approach to build software process models that work in the qualitative and quantitative fields, assessing the decision-making process and the software process improvement arena. The integration of this approach with current process assessment models (such as CMM), static and algorithmic models (such as traditional models used in the estimation process) and the design of a metrics collection program which is triggered by the actual process of model building will also be described in the chapter.Comisión Interministerial de Ciencia y Tecnología (CICYT) TIN2004-06689-C03-0

Effect of E1(64-81) hepatitis G peptide on the in vitro interaction of HIV-1 Fusion Peptide with membrane models

One way to gain information about the fusogenic potential of virus-derived synthetic peptides is to examine their interfacial properties and subsequently to study them in monolayers and bilayers. Here, we characterize the physicochemical surface properties of the peptide E1(64-81), whose sequence is AQLVGELGSLYGPLSVSA. This peptide is derived from the E1 structural protein of GBV-C/HGV which was previously shown to inhibit leakage of vesicular contents caused by the HIV-1 fusion peptide (HIV-1 FP). Mixed isotherms of E1(64-81) and HIV-1 FP were obtained and their Brewster angle microscopy (BAM) and atomic force microscopy (AFM) images showed that the peptide mixture forms a different structure that is not present in the pure peptide images. Studies with lipid monolayers (1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (DMPG) and 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DPPG)) show that both peptides interact with all the lipids assayed but the effect that HIV-1 FP has on the monolayers is reduced in the presence of E1(64-81). Moreover, differential scanning calorimetry (DSC) experiments show the capacity of HIV-1 FP to modify the properties of the bilayer structure and the capacity of E1(64-81) to inhibit these modifications. Our results indicate that E1(64-81) interacts with HIV-1 FP to form a new structure, and that this may be the cause of the previously observed inhibition of the activity of HIV-1 FP by E1(64-81)

Criterios de Interpretación de la Edad en los Otolitos de la Sardina (Sardina pilchardus) Atlántica Europea

Este manual tiene como objetivo describir los métodos para la determinación de la edad anual de la sardina (Sardina pilchardus, Walbaum, 1792). Las técnicas para la determinación de la edad en estructuras calcificadas de especies pelágicas y bentónicas (disección, preparación y métodos) en el área del ICES (aguas atlánticas europeas) se han descrito recientemente en un manual publicado tanto en inglés como en castellano (Villamor et al., 2015; 2016). Este nuevo manual que presentamos aquí se centra solo, pero en mayor profundidad, en los criterios utilizados y estandarizados a nivel europeo para la interpretación de los anillos de crecimiento anual en los otolitos (lectura de otolitos) de la sardina Atlántica Europea. Este manual tiene como finalidad servir de referencia para los lectores de edad de la sardina en los laboratorios del IEO y pretende también ser una guía para el entrenamiento de los nuevos participantes (lectores) en la determinación de la edad en los otolitos de sardina, para suplementar y complementar el entrenamiento que reciben del lector experto asignado para entrenarlos. También pretende ser una guía dinámica, que pueda cambiar a medida que sean introducidos nuevos criterios de interpretación tras ser evaluados y adoptados a nivel europeo. Este manual se basa en los últimos intercambios, talleres y publicaciones sobre la determinación de la edad de la sardina (ICES, 2005; 2011). También se hace referencia a la biología de la especie ya que es fundamental tener conocimiento de ella para poder interpretar los otolitos con mayor precisión