SMACS : modelling urban 3D environment (MURE)

OsloMet University is planning to close its campus in Kjeller in 2023 to create a new campus in the Romerike region. This change aims to improve and strengthen the synergies between the university and different companies in order to train students professionally, as well as to improve the quality of the campus in terms of accessibility and location, university life and even teaching. Four students from the European Project semester had the opportunity to take part in this project and propose a solution to design a potential new campus of OsloMet University based on an analysis of the people's flow from an existing building. This report shows the path followed during the whole semester, from the working methodology, the research, the contextualization and analysis of information and data to the final proposal: the creation of a tool to help in making decisions about the design and layout of the new campus to improve the people's flow and take advantage of all the available space. A hypothetical proposal has been developed of how the new campus could be distributed, providing three factors of flexibility in terms of location, number of people and rooms and versatility in the use of the available spaces. To show this in a visual way, a 3D model has been designed that allows you to enter the building and visualise how each of the floors that make up the campus are distributed.Grado en Ingeniería en Electrónica Industrial y Automátic

Comparison between different multidimensional analytical systems for protein identification

Comunicaciones a congreso

Enantioselective amination of 4-substituted pyrazolones catalyzed by oxindole-containing thioureas and by a recyclable linear-polymer-supported analogue in a continuous flow process

Producción CientíficaA highly efficient organocatalytic amination of 4-substituted pyrazolones with azodicarboxylates mediated by a novel quinine-derived thiourea with a 3,3-diaryl-oxindole scaffold is reported. This synthetic method furnished 4-amino-5-pyrazolones in high yields and with excellent enantioselectivities (up to 97:3 er) at room temperature in short reaction times. Moreover, a linear-polymer-supported bifunctional thiourea, synthesized by reacting a bifunctional aromatic monomer (biphenyl) with isatin in superacidic media and further derivatization, was proven to be also an efficient heterogeneous organocatalyst for this α-amination reaction. The practical value of this process was demonstrated by the use of the immobilized catalyst in recycling experiments, maintaining the activity without additional reactivation, and in flow processes, allowing the synthesis of 4-amino-pyrazolone derivatives in a gram scale with high yield and enantioselectivity.Agencia Estatal de Investigación- FEDER-UE (PID2020-118547GB-I00)Junta de Castilla y León (VA224P20

Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors

Background: Type 1 gastric neuroendocrine tumors (GC-1) represent an uncommon subtype of neoplasms. Endoscopic resection has been proposed as the treatment of choice; active surveillance may be performed in those smaller than 1 cm, while gastric surgery may be performed for those with frequent recurrences. The antiproliferative effect of somatostatin analogues (SSA) is well known, and their action on GC-1s has been postulated as a chronic treatment to reduce recurrence. Methods: A two-centered, retrospective, observational study that included nine patients (55.6% women) diagnosed with GC-1, receiving long-term treatment with SSA, with a median follow-up from baseline of 22 months, was undertaken. Endoscopic follow-up, extension study, and analytical values of chromogranin A (Cg A) and gastrin were collected. Results: In total, 88.9% of patients presented partial or complete response. Treatment with SSA was the only independent factor with a trend to prevent tumor recurrence (Odds Ratio 0.054; p = 0.005). A nonsignificant tendency toward a decrease in CgA and gastrin was observed; lack of significance was probably related to concomitant treatment with proton pump inhibitors in some patients. Conclusions: Chronic treatment with SSA is a feasible option for recurrent GC-1s that are difficult to manage using endoscopy or gastrectomy. Randomized clinical trials to provide more scientific evidence are still neede

Development of the Post Cardiac Surgery (POCAS) prognostic score

Producción CientíficaThe risk of mortality in cardiac surgery is generally evaluated using preoperative risk-scale models. However, intraoperative factors may change the risk factors of patients, and the organism functionality parameters determined upon ICU admittance could therefore be more relevant in deciding operative mortality. The goals of this study were to find associations between the general parameters of organism functionality upon ICU admission and the operative mortality following cardiac operations, to develop a Post Cardiac Surgery (POCAS) Scale to define operative risk categories and to validate an operative mortality risk score. Methods: We conducted a prospective study, including 920 patients who had undergone cardiac surgery with cardiopulmonary bypass. Several parameters recorded on their ICU admission were explored, looking for a univariate and multivariate association with in-hospital mortality (90 days). In-hospital mortality was 9%. Four independent factors were included in the POCAS mortality risk model: mean arterial pressure, bicarbonate, lactate and the International Normalized Ratio (INR). The POCAS scale was compared with four other risk scores in the validation series. Results: In-hospital mortality (90 days) was 9%. Four independent factors were included in the POCAS mortality risk model: mean arterial pressure, bicarbonate ratio, lactate ratio and the INR. The POCAS scale was compared with four other risk scores in the validation series. Discriminatory power (accuracy) was defined with a receiver-operating characteristics (ROC) analysis. The best accuracy in predicting in-hospital mortality (90 days) was achieved by POCAS. The areas under the ROC curves of the different systems analyzed were 0.890 (POCAS), followed by 0.847 (Simplified Acute Physiology Score (SAP II)), 0.825 (Sepsis-related Organ Failure Assessment (SOFA)), 0.768 (Acute Physiology and Chronic Health Evaluation (APACHE II)), 0.754 (logistic EuroSCORE), 0.714 (standard EuroSCORE) and 0.699 (Age, Creatinine, Ejection Fraction (ACEF) score). Conclusions: Our new system to predict the operative mortality risk of patients undergoing cardiac surgery is better than others used for this purpose (SAP II, SOFA, APACHE II, logistic EuroSCORE, standard EuroSCORE, and ACEF score). Moreover, it is an easy-to-use tool since it only requires four risk factors for its calculation.Junta de Castilla y León (grant GRS 463/A/10)Ministerio de Sanidad, Consumo y Bienestar Social (grant RD06/0001/0020

Generación coordinada e integración en la docencia de objetos y recursos virtuales de aprendizaje en las asignaturas de Didáctica de la Matemática del Grado en Educación Primaria

Tras la experiencia adquirida en el curso pasado en el uso de herramientas y recursos para la docencia online provocada por la suspensión de la actividad presencial debido a la pandemia, arrancamos este PID que buscaba el diseño, generación e integración en la docencia de objetos y recursos virtuales de aprendizaje, que fuesen útiles en cualquier modalidad de docencia (presencial, semipresencial u online) y con el objetivo de maximizar las oportunidades de aprendizaje de los estudiantes en dos asignaturas del grado en Educación Primaria. Por ello, mediante el presente PID se han desarrollado varios objetos de aprendizaje, a saber: cuestionarios de Moodle para la autoevaluación de los alumnos, que han sido muy bien aceptados y utilizados por los estudiantes, guiones de prácticas basados en materiales y recursos online, y varias píldoras en el formato “Saber, extender” que servirán tanto de material para varias asignaturas del área como de medio de difusión de conocimiento para la comunidad educativa. Aunque el objetivo inicial, además de desarrollar estos materiales, también incluía su implementación en el curso actual, solo se han podido implementar los cuestionarios de Moodle, pues los diferentes compromisos de los integrantes del equipo de trabajo han ralentizado el trabajo de diseño y generación. No obstante, gracias a la coordinación que se ha promovido entre el profesorado participante, creemos que este proyecto, inicialmente ambicioso, solo es el comienzo de futuras colaboraciones para el desarrollo de otros materiales y su implementación en los próximos cursos.Didáctica de las Ciencias Experimentales, Sociales y de la Matemátic