Electron transport measurements in liquid xenon with Xenoscope, a large-scale DARWIN demonstrator

This work was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme, grant agreement No. 742789 ( Xenoscope), by the SNF grant 20FL20-201437, as well as by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska -Curie grant agreement No 860881-HIDDeN. We thank the electronics and mechanical workshops in the UZH Physics Department for their continuous support. We thank Laura Manenti for insightful discussions about purity monitors.The DARWIN observatory is a proposed next-generation experiment with 40 tonnes of liquid xenon as an active target in a time projection chamber. To study challenges related to the construction and operation of a multi-tonne scale detector, we have designed and constructed a vertical, full-scale demonstrator for the DARWIN experiment at the University of Zurich. Here, we present the first results from a several-months run with 343 kg of xenon and electron drift lifetime and transport measurements with a 53 cm tall purity monitor immersed in the cryogenic liquid. After 88 days of continuous purification, the electron lifetime reached a value of (664 +/- 23) mu s. We measured the drift velocity of electrons for electric fields in the range (2575) V/cm, and found values consistent with previous measurements. We also calculated the longitudinal diffusion constant of the electron cloud in the same field range, and compared with previous data, as well as with predictions from an empirical model.European Research Council (ERC)European Union’s Horizon 2020 No. 742789SNF 20FL20-201437European Union’s Horizon 2020 Marie Skłodowska -Curie 860881-HIDDeNUZH Physics Departmen

The study of the effect of mannose in GALE Caenorhabditis elegans mutants using as food source Escherichia Coli mutants defective in mannose metabolism pathway

Type III galactosemia is a rare disease characterized by mutations in the GALE gene that encodes the enzyme UDP-galactose 4-epimerase. The deficit of this enzyme gives rise to various physical and mental problems in humans (Walter et al. 1999). Several studies in gale-1 mutants of C. elegans worms have shown a  positive effect of mannose (Brokate-Llanos et al. 2014), on the longevity and development of these mutants. These worms have as their main diet E. coli (OP50), so that the positive effects of mannose can be influenced by the transformation these bacteria can produce through metabolic transformation of mannose. Trying to eliminate this possible influence of OP50 mannose metabolism on these experiments, UV radiation inactivated  E.coli  has been used as worm food in the presence of different concentrations of mannose. This approach presents, among others, the problem that by inactivating bacteria by UV radiation we are eliminating their replication, but not their complete metabolism,demanding other experimental approaches as using E. coli strains unable to metabolize mannose to feed the worms. Therefore, the objective of this work is to study the effects of mannose in C. elegans, fed with OP50 mutants defective in different steps of mannose metabolism to assess the direct effects of mannose on C. elegans GALE mutants. - Construction of OP50 isogenic strains defective in different steps of mannose metabolism by transformation with mutant alleles obtained from E. coli (K12) mutant strains. OP50 was transformed by homologous recombination with fragments containing deletions in ΔmanA (gene for the enzyme of the sugars metabolism mannose derived pathway), ΔmanB (gene for the enzyme of the lipopolysaccharide synthesis mannose derived pathway) and ΔmanX (gene for one of the mannose transporters within the cell). These deleted genes were replaced by a kanamycin resistance gene. - Preparation of eggs of C. elegans and incubation in plates with different concentrations of mannose (0%, 1%, 2%, 3%).The E. coli used are the different mutant strains obtained and a control (wild type OP50). OP50 mutants for the genes indicated above were correctly obtained. They were tested with the GALE worms, and we observed that ΔmanA and ΔmanX show a great improvement in GALE mutants growth and development with respect to the wt OP50 control. Nevertheless, we did not observe these changes with ΔmanB. It seems that LPS pathway is probably important for the mannose asimilation

Impact of cross-section uncertainties on supernova neutrino spectral parameter fitting in the Deep Underground Neutrino Experiment

This document was prepared by the DUNE Collaboration using the resources of the Fermi National Accelerator Laboratory (Fermilab), a U.S. Department of Energy, Office of Science, HEP User Facility. Fermilab is managed by Fermi Research Alliance, LLC (FRA), acting under Contract No. DE-AC02-07CH11359. This work was supported by CNPq, FAPERJ, FAPEG and FAPESP, Brazil; CFI, IPP and NSERC, Canada; CERN; MSMT, Czech Republic; ERDF, H2020-EU and MSCA, European Union; CNRS/IN2P3 and CEA, France; INFN, Italy; FCT, Portugal; NRF, South Korea; CAM, Fundacion "La Caixa," Junta de Andalucia-FEDER, MICINN, and Xunta de Galicia, Spain; SERI and SNSF, Switzerland; TUBITAK, Turkey; The Royal Society and UKRI/STFC, United Kingdom; DOE and NSF, United States of America. This work was also supported by FAPESB T. O. PIE 0013/2016 and UESC/PROPP 0010299-61.A primary goal of the upcoming Deep Underground Neutrino Experiment (DUNE) is to measure the Oo10 thorn MeV neutrinos produced by a Galactic core-collapse supernova if one should occur during the lifetime of the experiment. The liquid-argon-based detectors planned for DUNE are expected to be uniquely sensitive to the & nu;e component of the supernova flux, enabling a wide variety of physics and astrophysics measurements. A key requirement for a correct interpretation of these measurements is a good understanding of the energy-dependent total cross section & sigma;oE & nu; thorn for charged-current & nu;e absorption on argon. In the context of a simulated extraction of supernova & nu;e spectral parameters from a toy analysis, we investigate the impact of & sigma;oE & nu; thorn modeling uncertainties on DUNE's supernova neutrino physics sensitivity for the first time. We find that the currently large theoretical uncertainties on & sigma;oE & nu; thorn must be substantially reduced before the & nu;e flux parameters can be extracted reliably; in the absence of external constraints, a measurement of the integrated neutrino luminosity with less than 10% bias with DUNE requires & sigma;oE & nu; thorn to be known to about 5%. The neutrino spectral shape parameters can be known to better than 10% for a 20% uncertainty on the cross-section scale, although they will be sensitive to uncertainties on the shape of & sigma;oE & nu; thorn . A direct measurement of low-energy & nu;e-argon scattering would be invaluable for improving the theoretical precision to the needed level.CERNERDF, H2020-EUMSCA, European UnionCAM, SpainLa Caixa FoundationJunta de Andalucia-FEDER, SpainSpanish GovernmentXunta de GaliciaMICINN, SpainFAPESB T. O. PIE0013/2016UESC/PROPP 0010299-6

Depth of maximum of air-shower profiles at the Pierre Auger Observatory. I. Measurements at energies above 10(17.8) eV

The successful installation, commissioning, and operation of the Pierre Auger Observatory would not have been possible without the strong commitment and effort from the technical and administrative staff in Malargue. We are very grateful to the following agencies and organizations for financial support: Comision Nacional de Energia Atomica, Fundacion Antorchas, Gobierno De La Provincia de Mendoza, Municipalidad de Malargue, NDM Holdings and Valle Las Lenas, in gratitude for their continuing cooperation over land access, Argentina; the Australian Research Council; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Financiadora de Estudos e Projetos (FINEP), Fundacao de Amparo a Pesquisa do Estado de Rio de Janeiro (FAPERJ), Sao Paulo Research Foundation (FAPESP) Grants No. 2010/07359-6, No. 1999/05404-3, Ministerio de Ciencia e Tecnologia (MCT), Brazil; MSMT-CR LG13007, 7AMB14AR005, CZ.1.05/2.1.00/03.0058 and the Czech Science Foundation Grant No. 14-17501S, Czech Republic; Centre de Calcul IN2P3/CNRS, Centre National de la Recherche Scientifique (CNRS), Conseil Regional Ile-de-France, Departement Physique Nucleaire et Corpusculaire (PNC-IN2P3/CNRS), Departement Sciences de l'Univers (SDU-INSU/CNRS), Institut Lagrange de Paris, ILP LABEX ANR-10-LABX-63, within the Investissements d'Avenir Programme ANR-11-IDEX-0004-02, France; Bundesministerium fur Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), Finanzministerium Baden-Wurttemberg, Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF), Ministerium fur Wissenschaft und Forschung, Nordrhein Westfalen, Ministerium fur Wissenschaft, Forschung und Kunst, Baden-Wurttemberg, Germany; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), Gran Sasso Center for Astroparticle Physics (CFA), CETEMPS Center of Excellence, Italy; Consejo Nacional de Ciencia y Tecnologia (CONACYT), Mexico; Ministerie van Onderwijs, Cultuur en Wetenschap, Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Stichting voor Fundamenteel Onderzoek der Materie (FOM), Netherlands; National Centre for Research and Development, Grants No. ERA-NET-ASPERA/01/11 and No. ERA-NET-ASPERA/02/11, National Science Centre, Grants No. 2013/08/M/ST9/00322, No. 2013/08/M/ST9/00728 and No. HARMONIA 5 - 2013/10/M/ST9/00062, Poland; Portuguese national funds and FEDER funds within COMPETE - Programa Operacional Factores de Competitividade through Fundacao para a Ciencia e a Tecnologia, Portugal; Romanian Authority for Scientific Research ANCS, CNDI-UEFISCDI partnership projects nr. 20/2012 and nr. 194/2012, project nr. 1/ASPERA2/2012 ERA-NET, PN-II-RU-PD-2011-3-0145-17, and PN-II-RU-PD-2011-3-0062, the Minister of National Education, Programme for research - Space Technology and Advanced Research - STAR, project no. 83/2013, Romania; Slovenian Research Agency, Slovenia; Comunidad de Madrid, FEDER funds, Ministerio de Educacion y Ciencia, Xunta de Galicia, European Community 7th Framework Program, Grant No. FP7-PEOPLE-2012-IEF-328826, Spain; Science and Technology Facilities Council, U.K.; Department of Energy, Contracts No. DE-AC02-07CH11359, No. DE-FR02-04ER41300, No. DE-FG02-99ER41107 and No. DE-SC0011689, National Science Foundation, Grant No. 0450696, The Grainger Foundation, USA; NAFOSTED, Vietnam; Marie Curie-IRSES/EPLANET, European Particle Physics Latin American Network, European Union 7th Framework Program, Grant No. PIRSES-2009-GA-246806; and UNESCO.We report a study of the distributions of the depth of maximum, Xmax, of extensive air-shower profiles with energies above 1017.8  eV as observed with the fluorescence telescopes of the Pierre Auger Observatory. The analysis method for selecting a data sample with minimal sampling bias is described in detail as well as the experimental cross-checks and systematic uncertainties. Furthermore, we discuss the detector acceptance and the resolution of the Xmax measurement and provide parametrizations thereof as a function of energy. The energy dependence of the mean and standard deviation of the Xmax distributions are compared to air-shower simulations for different nuclear primaries and interpreted in terms of the mean and variance of the logarithmic mass distribution at the top of the atmosphere.Comision Nacional de Energia AtomicaFundacion AntorchasGobierno De La Provincia de MendozaMunicipalidad de MalargueNDM HoldingsValle Las LenasAustralian Research CouncilNational Council for Scientific and Technological Development (CNPq)Ciencia Tecnologia e Inovacao (FINEP)Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) 2010/07359-6 1999/05404-3Ministerio de Ciencia e Tecnologia (MCT), BrazilGrant Agency of the Czech Republic Czech Republic Government 14-17501SCentre National de la Recherche Scientifique (CNRS)Region Ile-de-FranceDepartement Sciences de l'Univers (SDU-INSU/CNRS)Institut Lagrange de ParisFrench National Research Agency (ANR) ANR-10-LABX-63 ANR-11-IDEX-0004-02Federal Ministry of Education & Research (BMBF)German Research Foundation (DFG)Finanzministerium Baden-WurttembergHelmholtz AssociationMinisterium fur Wissenschaft und ForschungNordrhein WestfalenMinisterium fur WissenschaftForschung und KunstBaden-Wurttemberg, GermanyIstituto Nazionale di Fisica Nucleare (INFN)Ministry of Education, Universities and Research (MIUR)Gran Sasso Center for Astroparticle Physics (CFA)CETEMPS Center of Excellence, ItalyConsejo Nacional de Ciencia y Tecnologia (CONACyT)Ministerie van Onderwijs, Cultuur en WetenschapNetherlands Organization for Scientific Research (NWO)FOM (The Netherlands) Netherlands GovernmentNational Centre for Research and Development ERA-NET-ASPERA/01/11 ERA-NET-ASPERA/02/11National Science Centre, Poland 2013/08/M/ST9/00322 2013/08/M/ST9/00728 HARMONIA 5 - 2013/10/M/ST9/00062Portuguese national funds within COMPETE - Programa Operacional Factores de Competitividade through Fundacao para a Ciencia e a Tecnologia, PortugalFEDER funds within COMPETE - Programa Operacional Factores de Competitividade through Fundacao para a Ciencia e a Tecnologia, PortugalRomanian Authority for Scientific Research ANCSCNDI-UEFISCDI 20/2012 194/2012 1/ASPERA2/2012 ERA-NET PN-II-RU-PD-2011-3-0145-17 PN-II-RU-PD-2011-3-0062Minister of National Education, Programme for research - Space Technology and Advanced Research - STAR, Romania 83/2013Slovenian Research Agency - SloveniaComunidad de Madrid Instituto de Salud Carlos IIIEuropean Union (EU)Spanish GovernmentXunta de GaliciaEuropean Community 7th Framework Program, Spain FP7-PEOPLE-2012-IEF-328826Science & Technology Facilities Council (STFC)United States Department of Energy (DOE) DE-AC02-07CH11359 DE-FR02-04ER41300 DE-FG02-99ER41107 DE-SC0011689National Science Foundation (NSF) 0450696Grainger Foundation, USANational Foundation for Science & Technology Development (NAFOSTED)European Union (EU) PIRSES-2009-GA-246806UNESCOMSMT-CR LG130077AMB14AR005CZ.1.05/2.1.00/03.005

Dickkopf Proteins and Their Role in Cancer: A Family of Wnt Antagonists with a Dual Role

Dickkopf; Wnt antagonists; Wnt signalingDickkopf; Antagonistes Wnt; Senyalització WntDickkopf; Antagonistas Wnt; Señalización WntThe Wnt signaling pathway regulates crucial aspects such as cell fate determination, cell polarity and organogenesis during embryonic development. Wnt pathway deregulation is a hallmark of several cancers such as lung, gastric and liver cancer, and has been reported to be altered in others. Despite the general agreement reached by the scientific community on the oncogenic potential of the central components of the pathway, the role of the antagonist proteins remains less clear. Deregulation of the pathway may be caused by overexpression or downregulation of a wide range of antagonist proteins. Although there is growing information related to function and regulation of Dickkopf (DKK) proteins, their pharmacological potential as cancer therapeutics still has not been fully developed. This review provides an update on the role of DKK proteins in cancer and possible potential as therapeutic targets for the treatment of cancer; available compounds in pre-clinical or clinical trials are also reviewed.This work was supported by grants from Institut Català d’Oncologia (ICO); Instituto de Salud Carlos III (PI18/00398 and PI21/00640); La Marató de TV3 (201937); Fundació A.BOSCH; Rotary Clubs Barcelona Eixample, Barcelona Diagonal, Santa Coloma de Gramanet, München-Blutenburg, Deutschland Gemeindienst e.V. and others from Barcelona and province; Eric Abidal Foundation and Mi compañero de viaje

Analysis of Cancer Genomic Amplifications Identifies Druggable Collateral Dependencies within the Amplicon

Cancer; Drug development; Gene amplificationsCáncer; Desarrollo de fármacos; Amplificaciones de genesCàncer; Desenvolupament de medicaments; Amplificacions de gensThe identification of novel therapeutic targets for specific cancer molecular subtypes is crucial for the development of precision oncology. In the last few years, CRISPR/Cas9 screens have accelerated the discovery and validation of new targets associated with different tumor types, mutations, and fusions. However, there are still many cancer vulnerabilities associated with specific molecular features that remain to be explored. Here, we used data from CRISPR/Cas9 screens in 954 cancer cell lines to identify gene dependencies associated with 16 common cancer genomic amplifications. We found that high-copy-number genomic amplifications generate multiple collateral dependencies within the amplified region in most cases. Further, to prioritize candidate targets for each chromosomal region amplified, we integrated gene dependency parameters with both druggability data and subcellular location. Finally, analysis of the relationship between gene expression and gene dependency led to the identification of genes, the expression of which may constitute predictive biomarkers of dependency. In conclusion, our study provides a set of druggable targets specific for each amplification, opening the possibility to specifically target amplified tumors on this basis.This research was funded by grants from Institut Català d’Oncologia (ICO), Instituto de Salud Carlos III (PI21/00640), AGAUR (2021 FI_B 00088), Fundació BOSCH, Iniciativa Tot per tu, Fundació Amics Joan Petit, and Mi compañero de viaje

Search for heavy stable charged particles in pp collisions at ?s = 7 TeV

The result of a search at the LHC for heavy stable charged particles produced in pp collisions at s?=7TeV is described. The data sample was collected with the CMS detector and corresponds to an integrated luminosity of 3.1 pb?1. Momentum and ionization-energy-loss measurements in the inner tracker detector are used to identify tracks compatible with heavy slow-moving particles. Additionally, tracks passing muon identification requirements are also analyzed for the same signature. In each case, no candidate passes the selection, with an expected background of less than 0.1 events. A lower limit at the 95% confidence level on the mass of a stable gluino is set at 398GeV/c 2, using a conventional model of nuclear interactions that allows charged hadrons containing this particle to reach the muon detectors. A lower limit of 311 GeV/c 2 is also set for a stable gluino in a conservative scenario of complete charge suppression, where any hadron containing this particle becomes neutral before reaching the muon detectors.We are grateful to Anna Kulesza and Michael Krämer for providing the theoretical production cross sections and associated uncertainties at next-to-leading order for pair production of eg and ˜t1. We wish to congratulate our colleagues in the CERN accelerator departments for the excellent performance of the LHC machine. We thank the technical and administrative staff at CERN and other CMS institutes, and acknowledge support from: FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia); Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTD (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)

Search for a W'' boson decaying to a muon and a neutrino in pp collisions at vs=7 TeV

A new heavy gauge boson, , decaying to a muon and a neutrino, is searched for in pp collisions at a centre-of-mass energy of 7 TeV. The data, collected with the CMS detector at the LHC, correspond to an integrated luminosity of 36 pb?1. No significant excess of events above the standard model expectation is found in the transverse mass distribution of the muon?neutrino system. Masses below 1.40 TeV are excluded at the 95% confidence level for a sequential standard-model-like . The mass lower limit increases to 1.58 TeV when the present analysis is combined with the CMS result for the electron channel.We wish to congratulate our colleagues in the CERN accelerator departments for the excellent performance of the LHC machine. We thank the technical and administrative staff at CERN and other CMS institutes, and acknowledge support from: FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia); Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLPFAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTD (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)

Search for resonances in the dijet mass spectrum from 7 TeV pp collisions at CMS

A search for narrow resonances with a mass of at least 1 TeV in the dijet mass spectrum is performed using pp collisions at ?s = 7 TeV corresponding to an integrated luminosity of 1 fb?1, collected by the CMS experiment at the LHC. No resonances are observed. Upper limits at the 95% confidence level are presented on the product of the resonance cross section, branching fraction into dijets, and acceptance, separately for decays into quark?quark, quark?gluon, and gluon?gluon pairs. The data exclude new par- ticles predicted in the following models at the 95% confidence level: string resonances with mass less than 4.00 TeV, E6 diquarks with mass less than 3.52 TeV, excited quarks with mass less than 2.49 TeV, axigluons and colorons with mass less than 2.47 TeV, and W? bosons with mass less than 1.51 TeV. These results extend previous exclusions from the dijet mass search technique.We wish to congratulate our colleagues in the CERN accelerator departments for the excellent performance of the LHC machine. We thank the technical and administrative staff at CERN and other CMS institutes, and acknowledge support from: FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia); Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTD (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA). We thank Can Kilic for calculations of the string resonance cross section

Search for light resonances decaying into pairs of muons as a signal of new physics

A search for groups of collimated muons is performed using a data sample collected by the CMS experiment at the LHC, at a centre-of-mass energy of 7 TeV, and corresponding to an integrated luminosity of 35 pb?1 . The analysis searches for production of new low-mass states decaying into pairs of muons and is designed to achieve high sensitivity to a broad range of models predicting leptonic jet signatures. With no excess observed over the background expectation, upper limits on the production cross section times branching fraction times acceptance are set, ranging from 0.1 to 0.5 pb at the 95% CL depending on event topology. In addition, the results are interpreted in several benchmark models in the context of supersymmetry with a new light dark sector exploring previously inaccessible parameter space.We wish to congratulate our colleagues in the CERN accelerator departments for the excellent performance of the LHC machine. We thank the technical and administrative staff at CERN and other CMS institutes, and acknowledge support from: FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); MSI (New Zealand); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTD (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)